N‐acetylneuraminic acid modulates SQSTM1/p62 sialyation‐mediated ubiquitination degradation contributing to vascular endothelium dysfunction in experimental atherosclerosis mice

Empagliflozin inhibits excessive autophagy through the AMPK/GSK3β signalling pathway in diabetic cardiomyopathy

(2023) Rosalinda Madonna et al.   CARDIOVASCULAR RESEARCH

Red Meat Derived Glycan, N-acetylneuraminic Acid (Neu5Ac) Is a Major Sialic Acid in Different Skeletal Muscles and Organs of Nine Animal Species—A Guideline for Human Consumers

(2023) Marefa Jahan et al.   Foods

Endothelial mechanobiology in atherosclerosis

(2023) Xiaoli Wang et al.   CARDIOVASCULAR RESEARCH

Association of cyclophilins and cardiovascular risk factors in coronary artery disease

(2023) Sandra Gegunde et al.   Frontiers in Physiology

Sialic acids promote macrophage M1 polarization and atherosclerosis by upregulating ROS and autophagy blockage

(2023) Xuemei Hu et al.   International Immunopharmacology

Large-leaf yellow tea attenuates high glucose-induced vascular endothelial cell injury by up-regulating autophagy and down-regulating oxidative stress

(2022) Pu Wang et al.   Food & Function

Andrographolide suppresses non-small-cell lung cancer progression through induction of autophagy and antitumor immune response

(2022) Xuan-Run Wang et al.   PHARMACOLOGICAL RESEARCH

Protocatechualdehyde Rescues Oxygen-Glucose Deprivation/Reoxygenation-Induced Endothelial Cells Injury by Inducing Autophagy and Inhibiting Apoptosis via Regulation of SIRT1

(2022) Shidong Cao et al.   Frontiers in Pharmacology

Role of glycolysis in the development of atherosclerosis

(2022) Lanfang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis

(2022) Jiang-Yun Luo et al.   CIRCULATION RESEARCH

Animal Models of Atherosclerosis–Supportive Notes and Tricks of the Trade

(2022) Anton Gisterå et al.   CIRCULATION RESEARCH

Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway

(2022) Bingxin Zheng et al.   Cell and Bioscience

Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles

(2022) Na Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

Activation of Cholinergic Anti-Inflammatory Pathway Ameliorates Cerebral and Cardiac Dysfunction After Intracerebral Hemorrhage Through Autophagy

(2022) Yue Su et al.   Frontiers in Immunology

Trimethylamine-N-oxide (TMAO) promotes balloon injury-induced neointimal hyperplasia via upregulating Beclin1 and impairing autophagic flux

(2022) Qingqing Hong et al.   BIOMEDICINE & PHARMACOTHERAPY

ANGPTL4 attenuates palmitic acid-induced endothelial cell injury by increasing autophagy

(2022) Wanlin Zhan et al.   CELLULAR SIGNALLING

α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting

(2022) Liping Wang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Peripheral blood derived endothelial colony forming cells as suitable cell source for pre-endothelialization of arterial vascular grafts under dynamic flow conditions

(2022) Xenia Kraus et al.   MICROVASCULAR RESEARCH

Zhenbao pill attenuates hydrogen peroxide–induced apoptosis by inhibiting autophagy in human umbilical vein endothelial cells

(2021) Yuchen Jia et al.   JOURNAL OF ETHNOPHARMACOLOGY

Autophagy-induced p62 accumulation is required for curcumol to regulate KLF5-mediated angiogenesis in liver sinusoidal endothelial cells

(2021) Liyuan Gao et al.   TOXICOLOGY

Enhanced Autophagy in GAB1-Deficient Vascular Endothelial Cells Is Responsible for Atherosclerosis Progression

(2021) Xin Qian et al.   Frontiers in Physiology

The changing landscape of atherosclerosis

(2021) Peter Libby   NATURE

Sialic acid as a potential biomarker for cardiovascular disease, diabetes and cancer

(2021) Jack Cheeseman et al.   Biomarkers in Medicine

Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis

(2021) Marco Witkowski et al.   CARDIOVASCULAR RESEARCH

Pectin Oligosaccharides Enhance α2,6-Sialylation Modification that Promotes Apoptosis of Bladder Cancer Cells by Targeting the Hedgehog Pathway

(2021) Yinpeng Huang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

P62 Links the Autophagy Pathway and the Ubiquitin–Proteasome System in Endothelial Cells during Atherosclerosis

(2021) SeJeong Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Focus on ferroptosis, pyroptosis, apoptosis and autophagy of vascular endothelial cells to the strategic targets for the treatment of atherosclerosis

(2021) Xiaoyan Lin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated With Human-Like Neu5Gc Loss—Brief Report

(2021) Kunio Kawanishi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis

(2020) Xinbo Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy

(2020) Qinghai Meng et al.   Journal of Advanced Research

Mechanism overview and target mining of atherosclerosis: Endothelial cell injury in atherosclerosis is regulated by glycolysis (Review)

(2020) Ruiying Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR

(2020) Xianmei Pan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms

(2019) Kunio Kawanishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

(2019) Gloria Salazar et al.   Autophagy

Sialic acid metabolism as a potential therapeutic target of atherosclerosis

(2019) Chao Zhang et al.   Lipids in Health and Disease

Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress

(2019) Zhiyuan You et al.   Nature Communications

Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy

(2017) Satoko ARAKAWA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Functional Metabolomics Characterizes a Key Role for N -Acetylneuraminic Acid in Coronary Artery Diseases

(2017) Lei Zhang et al.   CIRCULATION

Exogenous supplement of N-acetylneuraminic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice

(2016) Shoudong Guo et al.   ATHEROSCLEROSIS

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells

(2015) Peidu Jiang et al.   METHODS

Sialic Acid Rescues Repurified Lipopolysaccharide-Induced Acute Renal Failure via Inhibiting TLR4/PKC/gp91-Mediated Endoplasmic Reticulum Stress, Apoptosis, Autophagy, and Pyroptosis Signaling

(2014) Chih-Ching Yang et al.   TOXICOLOGICAL SCIENCES

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Combined effects of brachial pulse pressure and sialic acid for risk of cardiovascular events during 40 years of follow-up in 37 843 individuals

(2012) Payam Khalili et al.   JOURNAL OF HYPERTENSION

From endothelial dysfunction to atherosclerosis

(2010) S. Sitia et al.   AUTOIMMUNITY REVIEWS

Gangliosides induce autophagic cell death in astrocytes

(2010) Jaegyu Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Atherosclerosis profile and incidence of cardiovascular events: a population-based survey

(2009) Jennifer G Robinson et al.   BMC Cardiovascular Disorders

Effective Prevention and Treatment of Helicobacter pylori Infection Using a Combination of Catechins and Sialic Acid in AGS Cells and BALB/c Mice

(2008) Jyh-Chin Yang et al.   JOURNAL OF NUTRITION