Animal Models of Atherosclerosis–Supportive Notes and Tricks of the Trade

Endothelial Lipase Is Involved in Cold-Induced High-Density Lipoprotein Turnover and Reverse Cholesterol Transport in Mice

(2021) Nicola Schaltenberg et al.   Frontiers in Cardiovascular Medicine

Genetics of coronary artery disease in the post‐GWAS era

(2021) Zhifen Chen et al.   JOURNAL OF INTERNAL MEDICINE

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

(2020) Jan Borén et al.   EUROPEAN HEART JOURNAL

Immune Responses to Viral Gene Therapy Vectors

(2020) Jamie L. Shirley et al.   MOLECULAR THERAPY

Lipoprotein(a) Reduction in Persons with Cardiovascular Disease

(2020) Sotirios Tsimikas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of Monogenic vs Polygenic Hypercholesterolemia With Risk of Atherosclerotic Cardiovascular Disease

(2020) Mark Trinder et al.   JAMA Cardiology

Statins reduce vascular inflammation in atherogenesis: A review of underlying molecular mechanisms

(2020) Luca Liberale et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

New Insights into the Immune System Using Dirty Mice

(2020) Sara E. Hamilton et al.   JOURNAL OF IMMUNOLOGY

Colchicine in Patients with Chronic Coronary Disease

(2020) Stefan M. Nidorf et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Translational Mouse Model for NASH with Advanced Fibrosis and Atherosclerosis Expressing Key Pathways of Human Pathology

(2020) Anita M. van den Hoek et al.   Cells

Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

(2020) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

(2019) Changjun Yin et al.   NATURE MEDICINE

Association of Triglyceride-Lowering LPL Variants and LDL-C–Lowering LDLR Variants With Risk of Coronary Heart Disease

(2019) Brian A. Ference et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

(2019) Linzhang Huang et al.   NATURE

Laboratory mice born to wild mice have natural microbiota and model human immune responses

(2019) Stephan P. Rosshart et al.   SCIENCE

Quantification of Atherosclerosis in Mice

(2019) Monica Centa et al.   Jove-Journal of Visualized Experiments

Western Diet and the Immune System: An Inflammatory Connection

(2019) Anette Christ et al.   IMMUNITY

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

Induction of HLA-A2 restricted CD8 T cell responses against ApoB100 peptides does not affect atherosclerosis in a humanized mouse model

(2019) Frank H. Schaftenaar et al.   Scientific Reports

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis

(2018) Monica Centa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

LDL-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice

(2018) Anton Gisterå et al.   CIRCULATION

Lipid-driven immunometabolic responses in atherosclerosis

(2018) Anton Gisterå et al.   CURRENT OPINION IN LIPIDOLOGY

Of mice and men - environmental temperature, body temperature, and treatment of obesity

(2018) Marc L. Reitman   FEBS LETTERS

Hypercholesterolemia induces T cell expansion in humanized immune mice

(2018) Jonathan D. Proto et al.   JOURNAL OF CLINICAL INVESTIGATION

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events

(2018) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

NKT cells in cardiovascular diseases

(2017) Gijs H.M. van Puijvelde et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis

(2017) A. Gisterå et al.   JOURNAL OF INTERNAL MEDICINE

Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish

(2017) Chao Liu et al.   JOURNAL OF LIPID RESEARCH

The immunology of atherosclerosis

(2017) Anton Gisterå et al.   Nature Reviews Nephrology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trials and Tribulations of CETP Inhibitors

(2017) Alan R. Tall et al.   CIRCULATION RESEARCH

Age-associated vascular inflammation promotes monocytosis during atherogenesis

(2016) Wei Du et al.   AGING CELL

ApoE knockout rabbits: A novel model for the study of human hyperlipidemia

(2016) Manabu Niimi et al.   ATHEROSCLEROSIS

Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance

(2016) Xiao Yu Tian et al.   Cell Metabolism

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake

(2015) J. P. Otis et al.   Disease Models & Mechanisms

Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response

(2015) Emilie K. Grasset et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains

(2015) Brian J. Bennett et al.   PLoS Genetics

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

(2015) Robert Schierwagen et al.   Scientific Reports

An accelerated mouse model for atherosclerosis and adipose tissue inflammation

(2014) Angelika Neuhofer et al.   Cardiovascular Diabetology

Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering

(2014) Martin Mæng Bjørklund et al.   CIRCULATION RESEARCH

LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses

(2014) Shao-hua Wang et al.   Lipids in Health and Disease

Anti-Atherogenic Effects of Methotrexate Carried by a Lipid Nanoemulsion That Binds to LDL Receptors in Cholesterol-fed Rabbits

(2013) Adriana Bulgarelli et al.   CARDIOVASCULAR DRUGS AND THERAPY

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

(2013) Roland Klingenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant

(2013) R. H. Al-Mashhadi et al.   Science Translational Medicine

Biomechanical modeling and morphology analysis indicates plaque rupture due to mechanical failure unlikely in atherosclerosis-prone mice

(2012) Ian C. Campbell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Apolipoprotein E gene mutations in subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia

(2012) María Solanas-Barca et al.   ATHEROSCLEROSIS

Increased Inflammation in Atherosclerotic Lesions of DiabeticAkita-LDLr−/−Mice Compared to NondiabeticLDLr−/−Mice

(2012) Daniel Engelbertsen et al.   Experimental Diabetes Research

Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

(2012) Eszter Molnár et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease

(2012) Veerle Bieghs et al.   PLoS One

Spontaneously diabetic Ins2+/Akita:apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis

(2011) John Y. Jun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Treatment With Methotrexate Inhibits Atherogenesis in Cholesterol-Fed Rabbits

(2011) Adriana Bulgarelli et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

(2011) Andrew J. Murphy et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperglycemic Ins2AkitaLdlr−/−mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease

(2011) Changcheng Zhou et al.   JOURNAL OF LIPID RESEARCH

Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models

(2011) M C Deeds et al.   LABORATORY ANIMALS

Use of hamster as a model to study diet-induced atherosclerosis

(2011) Alice Dillard et al.   Nutrition & Metabolism

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

(2010) Maik Drechsler et al.   CIRCULATION

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Human CETP aggravates atherosclerosis by increasing VLDL-cholesterol rather than by decreasing HDL-cholesterol in APOE*3-Leiden mice

(2009) Jitske de Vries-van der Weij et al.   ATHEROSCLEROSIS

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Vascular Lipid Accumulation, Lipoprotein Oxidation, and Macrophage Lipid Uptake in Hypercholesterolemic Zebrafish

(2009) Konstantin Stoletov et al.   CIRCULATION RESEARCH

Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of agedApoE−/−mice

(2009) Rolf Gräbner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased locomotor activity in mice lacking the low-density lipoprotein receptor

(2008) Gregory A. Elder et al.   BEHAVIOURAL BRAIN RESEARCH

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY

Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice

(2007) Robin D. Atkinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM