Focus on ferroptosis, pyroptosis, apoptosis and autophagy of vascular endothelial cells to the strategic targets for the treatment of atherosclerosis

Estrogen Regulates Endoplasmic Reticulum Stress–Mediated Apoptosis by ERK-p65 Pathway to Promote Endometrial Angiogenesis

(2021) Yu Zhang et al.   Reproductive Sciences

Role of ferroptosis in the process of diabetes-induced endothelial dysfunction

(2021) Er-Fei Luo et al.   World Journal of Diabetes

Enhanced Autophagy in GAB1-Deficient Vascular Endothelial Cells Is Responsible for Atherosclerosis Progression

(2021) Xin Qian et al.   Frontiers in Physiology

Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells

(2021) Zhewei Zhao et al.   Aging-US

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells

(2021) Xia Qin et al.   Autophagy

PDSS2 inhibits the ferroptosis of vascular endothelial cells in atherosclerosis via activating Nrf2

(2021) Kai Yang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

(2020) Hui Zhao et al.   BIOSCIENCE REPORTS

Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis

(2020) Sha-Sha Xing et al.   INFLAMMATION

Trimethylamine N‐oxide promotes apoE −/− mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway

(2020) Peng Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Salvianolic acid B protects against oxLDL-induced endothelial dysfunction under high-glucose conditions by downregulating ROCK1-mediated mitophagy and apoptosis

(2020) Young Shin Ko et al.   BIOCHEMICAL PHARMACOLOGY

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

(2020) Mausita Karmakar et al.   Nature Communications

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

(2020) Tao Bai et al.   FREE RADICAL BIOLOGY AND MEDICINE

MLKL Aggravates Ox-LDL-Induced Cell Pyroptosis via Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells

(2020) Qian Wu et al.   INFLAMMATION

Cannabidiol Promotes Endothelial Cell Survival by Heme Oxygenase-1-Mediated Autophagy

(2020) Sabine Böckmann et al.   Cells

Halofuginone inhibits LPS-induced attachment of monocytes to HUVECs

(2020) Ming Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction

(2019) Francesca Vinchi et al.   EUROPEAN HEART JOURNAL

Autophagy in endothelial cells and tumor angiogenesis

(2019) Marco B. Schaaf et al.   CELL DEATH AND DIFFERENTIATION

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Role of autophagy in atherosclerosis: foe or friend?

(2019) Mehdi Hassanpour et al.   Journal of Inflammation-London

miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis

(2019) Feng-Jun Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway

(2019) Zhongsheng Zhu et al.   BMC Complementary and Alternative Medicine

Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway

(2019) Yang-Shuo Tang et al.   INFLAMMATION RESEARCH

Resveratrol attenuates endothelial oxidative injury by inducing autophagy via the activation of transcription factor EB

(2019) Xi Zhou et al.   Nutrition & Metabolism

Redox control of vascular biology

(2019) Milan Obradovic et al.   BIOFACTORS

Chronic iron overload intensifies atherosclerosis in apolipoprotein E deficient mice: Role of oxidative stress and endothelial dysfunction

(2019) Vinícius Bermond Marques et al.   LIFE SCIENCES

Iron and Atherosclerosis: The Link Revisited

(2019) Suowen Xu   TRENDS IN MOLECULAR MEDICINE

Atorvastatin inhibits pyroptosis through the lncRNA NEXN-AS1/NEXN pathway in human vascular endothelial cells

(2019) Li-Mei Wu et al.   ATHEROSCLEROSIS

Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway

(2019) Yang Liu et al.   BMC Cardiovascular Disorders

Endothelial autophagic flux hampers atherosclerotic lesion development

(2018) Marouane Kheloufi et al.   Autophagy

MicroRNA-142-3p Induces Atherosclerosis-Associated Endothelial Cell Apoptosis by Directly Targeting Rictor

(2018) Bing Qin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

(2018) Eran Agmon et al.   Scientific Reports

Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells

(2018) Chunteng Jiang et al.   TOXICOLOGY

Knockdown of growth-arrest specific transcript 5 restores oxidized low-density lipoprotein-induced impaired autophagy flux via upregulating miR-26a in human endothelial cells

(2018) Weijie Liang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

OxLDL induces vascular endothelial cell pyroptosis through miR‐125a‐5p/TET2 pathway

(2018) Zeng Zhaolin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quercetin alleviates high glucose-induced damage on human umbilical vein endothelial cells by promoting autophagy

(2018) Aysa Rezabakhsh et al.   PHYTOMEDICINE

Autophagy in health and disease: focus on the cardiovascular system

(2017) Jeanne Mialet-Perez et al.   Essays in Biochemistry

Role of NLRP3 Inflammasomes in Atherosclerosis

(2017) Tadayoshi Karasawa et al.   Journal of Atherosclerosis and Thrombosis

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis

(2017) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Low shear stress-induced autophagy alleviates cell apoptosis in HUVECs

(2017) Guo Dong et al.   Molecular Medicine Reports

Investigation of highly expressed PCSK9 in atherosclerotic plaques and ox-LDL-induced endothelial cell apoptosis

(2017) Jiao Li et al.   Molecular Medicine Reports

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

(2017) Anne-Clemence Vion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia

(2017) Saisudha Koka et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Tetrahydroxystilbene Glucoside Inhibits Excessive Autophagy and Improves Microvascular Endothelial Dysfunction in Prehypertensive Spontaneously Hypertensive Rats

(2016) Qianqian Dong et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

High-Density Lipoprotein–Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1Highlights

(2016) Mario Ruiz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular endothelium – Gatekeeper of vessel health

(2016) Paul A. Cahill et al.   ATHEROSCLEROSIS

Laminar Shear Stress Promotes Vascular Endothelial Cell Autophagy Through Upregulation with Rab4

(2016) Pingbo Yao et al.   DNA AND CELL BIOLOGY

Notch1 inhibition reduces low shear stress-induced plaque formation

(2016) Wei-dong Qin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells

(2016) Haiyan Chen et al.   TOXICOLOGY LETTERS

Cyclic and constant hyperoxia cause inflammation, apoptosis and cell death in human umbilical vein endothelial cells

(2015) J. Wu et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Intact endothelial autophagy is required to maintain vascular lipid homeostasis

(2015) Kumiko Torisu et al.   AGING CELL

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 PathwaySignificance

(2015) Ying Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autophagy and Apoptosis in the Response of Human Vascular Endothelial Cells to Oxidized Low-Density Lipoprotein

(2015) Yanlin Zhang et al.   CARDIOLOGY

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System

(2015) D. I. Brown et al.   CIRCULATION RESEARCH

Autophagy in Vascular Disease

(2015) G. R. Y. De Meyer et al.   CIRCULATION RESEARCH

Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis

(2015) Weiye Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Hyperphosphatemia induces protective autophagy in endothelial cells through the inhibition of Akt/mTOR signaling

(2015) Yu-Juei Hsu et al.   JOURNAL OF VASCULAR SURGERY

The Role of Oxidative Stress and Autophagy in Atherosclerosis

(2015) Ida Perrotta et al.   Oxidative Medicine and Cellular Longevity

Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression

(2015) J Liu et al.   Cell Death & Disease

MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis

(2015) Yong Zhang et al.   Scientific Reports

MicroRNAs in vascular aging and atherosclerosis

(2014) Rossella Menghini et al.   AGEING RESEARCH REVIEWS

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The role of iron metabolism as a mediator of macrophage inflammation and lipid handling in atherosclerosis

(2014) Anwer Habib et al.   Frontiers in Pharmacology

Anti-VEGF- and anti-VEGF receptor-induced vascular alteration in mouse healthy tissues

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of heparan sulfate proteoglycans enhances oxidized-LDL-mediated autophagy and apoptosis in human endothelial cells

(2012) Zufeng Ding et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Oxidized Low-Density Lipoprotein and Atherosclerosis Implications in Antioxidant Therapy

(2011) Sona Mitra et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Autophagy in Atherosclerosis

(2011) Dorien M. Schrijvers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells

(2011) Adam Csordas et al.   CARDIOVASCULAR RESEARCH

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax–caspase9–caspase3 pathway

(2011) Chun-Yan Wu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

The autophagy-lysosome pathway: A novel mechanism involved in the processing of oxidized LDL in human vascular endothelial cells

(2010) Yan-lin Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice

(2010) Wei-Jian Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Lipopolysaccharide induces autophagy through BIRC2 in human umbilical vein endothelial cells

(2010) Ning Meng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Resveratrol Attenuates Oxidized LDL-Evoked Lox-1 Signaling and Consequently Protects against Apoptotic Insults to Cerebrovascular Endothelial Cells

(2010) Huai-Chia Chang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Autophagy in Atherosclerosis

(2009) Wim Martinet et al.   CIRCULATION RESEARCH

Blockade of Oxidized LDL-Triggered Endothelial Apoptosis by Quercetin and Rutin through Differential Signaling Pathways Involving JAK2

(2009) Jung-Suk Choi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

(2009) Nigel A. Calcutt et al.   NATURE REVIEWS DRUG DISCOVERY

Inflammation stimulates the expression of PCSK9

(2008) Kenneth R. Feingold et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS