SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner

(2018) Avigail T. Erlich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis

(2018) Mandy O J Grootaert et al.   CARDIOVASCULAR RESEARCH

NADPH Oxidases and Mitochondria in Vascular Senescence

(2018) Gloria Salazar   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases

(2018) Tsukasa Kadota et al.   MOLECULAR ASPECTS OF MEDICINE

Zinc regulates Nox1 expression through a NF-κB and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells

(2017) G. Salazar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chemical screening identifies ATM as a target for alleviating senescence

(2017) Hyun Tae Kang et al.   Nature Chemical Biology

Moderate Autophagy Inhibits Vascular Smooth Muscle Cell Senescence to Stabilize Progressed Atherosclerotic Plaque via the mTORC1/ULK1/ATG13 Signal Pathway

(2017) Zhenli Luo et al.   Oxidative Medicine and Cellular Longevity

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

(2017) Haley R. Pugsley   Jove-Journal of Visualized Experiments

PGC-1α and exercise intensity dependent adaptations in mouse skeletal muscle

(2017) Nina Brandt et al.   PLoS One

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

(2016) Massimiliano Mellone et al.   Aging-US

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

The roles of autophagy in vascular smooth muscle cells

(2016) Shi Tai et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Loss of Mitochondrial Function Impairs Lysosomes

(2016) Julie Demers-Lamarche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis

(2016) Ismail Sergin et al.   Science Signaling

Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity

(2016) Yitong Zhao et al.   TRAFFIC

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis

(2016) Ismail Sergin et al.   Science Signaling

Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis

(2015) Mandy OJ Grootaert et al.   Autophagy

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases

(2015) Shiqin Xiong et al.   Cell Reports

Polymerase Delta Interacting Protein 2 Sustains Vascular Structure and Function

(2013) Roy L. Sutliff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Is a Central Negative Regulator of Vascular Senescence

(2013) Shiqin Xiong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GCN5-like Protein 1 (GCN5L1) Controls Mitochondrial Content through Coordinated Regulation of Mitochondrial Biogenesis and Mitophagy

(2013) Iain Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Complementary RNA and Protein Profiling Identifies Iron as a Key Regulator of Mitochondrial Biogenesis

(2013) Jarred W. Rensvold et al.   Cell Reports

ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner

(2012) Claudio Marcelo Fader et al.   Autophagy

Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage

(2012) Maria Teresa Viscomi et al.   Autophagy

Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

(2012) Jeongho Kwon et al.   EMBO REPORTS

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2012) E. Rubino et al.   NEUROLOGY

Angiotensin II Requires Zinc and Downregulation of the Zinc Transporters ZnT3 and ZnT10 to Induce Senescence of Vascular Smooth Muscle Cells

(2012) Nikolay Patrushev et al.   PLoS One

Selective autophagy in the maintenance of cellular homeostasis in aging organisms

(2011) Vanessa M. Hubbard et al.   BIOGERONTOLOGY

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Ageing theories unified

(2011) Daniel P. Kelly   NATURE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

(2011) Hyun Tae Kang et al.   PLoS One

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mitochondrial biogenesis in exercise and in ageing☆

(2009) Jose Viña et al.   ADVANCED DRUG DELIVERY REVIEWS

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

(2009) Claudio Marcelo Fader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PGC-1α Serine 570 Phosphorylation and GCN5-mediated Acetylation by Angiotensin II Drive Catalase Down-regulation and Vascular Hypertrophy

(2009) Shiqin Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC-1  is coupled to HIF-1 -dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

(2009) K. A. O'Hagan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

(2008) J. Ramesh Babu et al.   JOURNAL OF NEUROCHEMISTRY