Sialic acid metabolism as a potential therapeutic target of atherosclerosis

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

(2018) Anne Fougerat et al.   Molecular Metabolism

Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice

(2018) Elizabeth J. White et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presentation Mode of Glycans Affect Recognition of Human Serum anti-Neu5Gc IgG Antibodies

(2018) Salam Bashir et al.   BIOCONJUGATE CHEMISTRY

Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex

(2018) Charlotte Kawecki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of sialidase activity as a therapeutic approach

(2018) Victor Yu Glanz et al.   Drug Design Development and Therapy

Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions

(2018) Joyce Lübbers et al.   Frontiers in Immunology

Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance

(2017) Keiji Tanigaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Quercetin improves macrophage reverse cholesterol transport in apolipoprotein E-deficient mice fed a high-fat diet

(2017) Yingjie Cui et al.   Lipids in Health and Disease

Functional Metabolomics Characterizes a Key Role for N -Acetylneuraminic Acid in Coronary Artery Diseases

(2017) Lei Zhang et al.   CIRCULATION

Exogenous supplement of N-acetylneuraminic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice

(2016) Shoudong Guo et al.   ATHEROSCLEROSIS

Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice

(2016) Keiji Tanigaki et al.   DIABETES

Synthesis and cardiovascular protective effects of quercetin 7-O-sialic acid

(2016) Hua Tian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid

(2016) Frederico Alisson-Silva et al.   MOLECULAR ASPECTS OF MEDICINE

CMP-N-acetylneuraminic acid synthetase interacts with fragile X related protein 1

(2016) Yun Ma et al.   Molecular Medicine Reports

VariantASGR1Associated with a Reduced Risk of Coronary Artery Disease

(2016) Paul Nioi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

(2016) Maurizio Perdicchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells

(2016) Sabrina Gruber et al.   Cell Reports

The nutritional role of free sialic acid, a human milk monosaccharide, and its application as a functional food ingredient

(2015) Christoph H. Röhrig et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Modulation of sialic acid levels among some organs during insulin resistance or hyperglycemic states

(2015) Mohammed Auwal Ibrahim et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

N-Acetylneuraminic Acid Supplementation Prevents High Fat Diet-Induced Insulin Resistance in Rats through Transcriptional and Nontranscriptional Mechanisms

(2015) Zhang Yida et al.   Biomed Research International

N-Acetylneuraminic acid attenuates hypercoagulation on high fat diet-induced hyperlipidemic rats

(2015) Zhang Yida et al.   Food & Nutrition Research

Sialic Acids Sweeten a Tumor's Life

(2014) C. Bull et al.   CANCER RESEARCH

A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes

(2014) Farah Alghamdi et al.   CELLULAR SIGNALLING

Deficiency of the Sialyltransferase St3Gal4 Reduces Ccl5-Mediated Myeloid Cell Recruitment and Arrest

(2014) Yvonne Döring et al.   CIRCULATION RESEARCH

B Cells and Humoral Immunity in Atherosclerosis

(2014) Dimitrios Tsiantoulas et al.   CIRCULATION RESEARCH

Sialyltransferase Activity and Atherosclerosis

(2014) Andrew P. Sage et al.   CIRCULATION RESEARCH

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group BStreptococcus

(2014) Syed Raza Ali et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies

(2014) Dimitrios Tsiantoulas et al.   JOURNAL OF LIPID RESEARCH

Insulin Resistance and Skeletal Muscle Vasculature: Significance, Assessment and Therapeutic Modulators

(2014) Camila Manrique et al.   CardioRenal Medicine

Positive Regulation of Insulin Signaling by Neuraminidase 1

(2013) L. Dridi et al.   DIABETES

Sialic acid attenuates puromycin aminonucleoside-induced desialylation and oxidative stress in human podocytes

(2013) Izabella Z.A. Pawluczyk et al.   EXPERIMENTAL CELL RESEARCH

Regulatory T cells in atherosclerosis and strategies to induce the endogenous atheroprotective immune response

(2013) Dimitry A. Chistiakov et al.   IMMUNOLOGY LETTERS

Novel roles for the IgG Fc glycan

(2012) Robert M. Anthony et al.   Annals of the New York Academy of Sciences

Contribution of monocytes Siglec-1 in stimulating T cells proliferation and activation in atherosclerosis

(2012) Yi-song Xiong et al.   ATHEROSCLEROSIS

Mammalian sialidases: Physiological and pathological roles in cellular functions

(2012) T. Miyagi et al.   GLYCOBIOLOGY

Combined effects of brachial pulse pressure and sialic acid for risk of cardiovascular events during 40 years of follow-up in 37 843 individuals

(2012) Payam Khalili et al.   JOURNAL OF HYPERTENSION

Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice

(2012) Abraham Yang et al.   JOURNAL OF LIPID RESEARCH

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

(2011) Tetsuya Kubota et al.   Cell Metabolism

The Sialome—Far More Than the Sum of Its Parts

(2010) Miriam Cohen et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

(2009) T. Pham et al.   BLOOD

Use of Oseltamivir After Influenza Infection Is Associated With Reduced Incidence of Recurrent Adverse Cardiovascular Outcomes Among Military Health System Beneficiaries With Prior Cardiovascular Diseases

(2009) S. Ward Casscells et al.  

Siglec-1 on monocytes is a potential risk marker for monitoring disease severity in coronary artery disease

(2009) Yi-song Xiong et al.   CLINICAL BIOCHEMISTRY

Sialic acids as regulators of molecular and cellular interactions

(2009) Roland Schauer   CURRENT OPINION IN STRUCTURAL BIOLOGY

Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans

(2009) Meng-Yun Chou et al.   JOURNAL OF CLINICAL INVESTIGATION

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

The Influence of Oseltamivir Treatment on the Risk of Stroke after Influenza Infection

(2008) Mohammad Madjid et al.   CARDIOLOGY

Structural insights into sialic acid enzymology

(2008) Alejandro Buschiazzo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation

(2008) David Frommhold et al.   JOURNAL OF EXPERIMENTAL MEDICINE