Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles

Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics

(2021) Qinjie Weng et al.   Nature Communications

Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death

(2021) Longbin Zhang et al.   Nanotoxicology

Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction

(2021) Hongmei Zhou et al.   NEUROTOXICITY RESEARCH

Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages

(2021) Masahide Inoue et al.   Particle and Fibre Toxicology

Autophagy deficiency exacerbates acute lung injury induced by copper oxide nanoparticles

(2021) Junting Xiao et al.   JOURNAL OF NANOBIOTECHNOLOGY

KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

(2021) Pranavi Koppula et al.   iScience

NRF2 deficiency sensitizes human keratinocytes to zinc oxide nanoparticles-induced autophagy and cytotoxicity

(2021) Yuanyuan Yin et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The mechanism of cell death induced by silver nanoparticles is distinct from silver cations

(2021) Monica M. Rohde et al.   Particle and Fibre Toxicology

Serum apolipoprotein A-I depletion is causative to silica nanoparticles–induced cardiovascular damage

(2021) Xuting Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genes expression profiling of alveolar macrophages exposed to non-functionalized, anionic and cationic multi-walled carbon nanotubes shows three different mechanisms of toxicity

(2020) Sara Nahle et al.   JOURNAL OF NANOBIOTECHNOLOGY

Autophagy promotes mammalian survival by suppressing oxidative stress and p53

(2020) Yang Yang et al.   GENES & DEVELOPMENT

Copper Oxide Nanoparticles Induce Oxidative DNA Damage and Cell Death via Copper Ion-Mediated P38 MAPK Activation in Vascular Endothelial Cells

(2020) Hui He et al.   International Journal of Nanomedicine

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

(2020) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

(2020) Omar Lozano et al.   Particle and Fibre Toxicology

Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation

(2020) Lishi Xie et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

NFκB promotes oxidative stress-induced necrosis and ischemia/reperfusion injury by inhibiting Nrf2-ARE pathway

(2020) Xiaoyun Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nanoscale Spatial Distribution of Supported Nanoparticles Controls Activity and Stability in Powder Catalysts for CO Oxidation and Photocatalytic H2 Evolution

(2020) Alexander Holm et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The NADPH oxidase 4 protects vascular endothelial cells from copper oxide nanoparticles-induced oxidative stress and cell death

(2020) Hui He et al.   LIFE SCIENCES

Nanoparticle Toxicology

(2020) Wen Yang et al.   Annual Review of Pharmacology and Toxicology

Environmental pollutants and the immune response

(2020) Takafumi Suzuki et al.   NATURE IMMUNOLOGY

Mechano-bactericidal actions of nanostructured surfaces

(2020) Denver P. Linklater et al.   NATURE REVIEWS MICROBIOLOGY

Occupational exposure to carbon black nanoparticles increases inflammatory vascular disease risk: an implication of an ex vivo biosensor assay

(2020) Jinglong Tang et al.   Particle and Fibre Toxicology

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

(2020) Nobuaki Takahashi et al.   MOLECULAR CELL

Copper Oxide Nanoparticles Induce Enhanced Radiosensitizing Effect via Destructive Autophagy

(2019) Yao-Wen Jiang et al.   ACS Biomaterials-Science & Engineering

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles

(2019) Radwa Sehsah et al.   Particle and Fibre Toxicology

Nrf2: Molecular and epigenetic regulation during aging

(2018) A. Silva-Palacios et al.   AGEING RESEARCH REVIEWS

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

Silica nanoparticles induce autophagosome accumulation via activation of the EIF2AK3 and ATF6 UPR pathways in hepatocytes

(2018) Ji Wang et al.   Autophagy

Lysosomal deposition of copper oxide nanoparticles triggers HUVEC cells death

(2018) Jun Zhang et al.   BIOMATERIALS

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice

(2018) Anna-Kaisa Ruotsalainen et al.   CARDIOVASCULAR RESEARCH

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux

(2018) Eunkyoung Kim et al.   Cell Reports

Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation

(2018) Yuguang Zhao et al.   Redox Biology

Necrotic, apoptotic and autophagic cell fates triggered by nanoparticles

(2018) Reza Mohammadinejad et al.   Autophagy

Disruption of the Superoxide Anions-Mitophagy Regulation Axis Mediates Copper Oxide Nanoparticles-Induced Vascular Endothelial Cell Death

(2018) Jun Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles

(2017) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comparison between micro- and nanosized copper oxide and water soluble copper chloride: interrelationship between intracellular copper concentrations, oxidative stress and DNA damage response in human lung cells

(2017) Bettina Maria Strauch et al.   Particle and Fibre Toxicology

Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells

(2017) Jun Zhang et al.   Cell Death & Disease

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(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Changes in the microbiological and chemical characteristics of white bread during storage in paper packages modified with Ag/TiO2–SiO2, Ag/N–TiO2 or Au/TiO2

(2016) Anca Peter et al.   FOOD CHEMISTRY

An Essential Role of NRF2 in Diabetic Wound Healing

(2015) Min Long et al.   DIABETES

Downregulation of Nuclear Factor Erythroid 2–Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension

(2015) Rhéure A. Lopes et al.   HYPERTENSION

Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions

(2015) Valentina Turinetto et al.   NUCLEIC ACIDS RESEARCH

How safe are nanomaterials?

(2015) E. Valsami-Jones et al.   SCIENCE

Inhibition of autophagy enhances the anticancer activity of silver nanoparticles

(2014) Jun Lin et al.   Autophagy

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Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway

(2014) Shun Kageyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review

(2013) Olesja Bondarenko et al.   ARCHIVES OF TOXICOLOGY

A novel crosstalk between two major protein degradation systems

(2013) Xiao J Wang et al.   Autophagy

Molecular Mechanisms of Toxicity of Silver Nanoparticles in Zebrafish Embryos

(2013) Ronny van Aerle et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

(2012) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper Oxide Nanoparticles Induce Autophagic Cell Death in A549 Cells

(2012) Tingting Sun et al.   PLoS One

Keap1 degradation by autophagy for the maintenance of redox homeostasis

(2012) K. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Long-Term Inhalation Exposure to Nickel Nanoparticles Exacerbated Atherosclerosis in a Susceptible Mouse Model

(2010) Gi Soo Kang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Deletion ofKeap1in the Lung Attenuates Acute Cigarette Smoke–Induced Oxidative Stress and Inflammation

(2009) David J. Blake et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Application of Nanotechnology in Cancer Therapy and Imaging

(2008) X. Wang et al.   CA-A CANCER JOURNAL FOR CLINICIANS