Integration of a perfusion reactor and continuous precipitation in an entirely membrane‐based process for antibody capture

Coupling of chromatography and precipitation for adjusting acidic variant content in a monoclonal antibody pool

(2023) Patrycja Zimoch et al.   JOURNAL OF CHROMATOGRAPHY A

Continuous precipitation of antibodies using oscillatory flow reactor: A proof of concept

(2023) Diogo Ferreira-Faria et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Milliscale reactors for integration of continuous precipitation and filtration

(2022) Maria del Carme Pons Royo et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Redissolution of recombinant antibodies precipitated by ZnCl2

(2022) Gabriele Recanati et al.   PROCESS BIOCHEMISTRY

Preferential precipitation of acidic variants from monoclonal antibody pools

(2022) Tomasz Rumanek et al.   BIOTECHNOLOGY AND BIOENGINEERING

Poly (ethylene) glycol (PEG) precipitation of glycosylated and non-glycosylated monoclonal antibodies

(2022) Ke Li et al.   PROCESS BIOCHEMISTRY

Continuous precipitation of antibodies by feeding of solid polyethylene glycol

(2022) Maria del Carme Pons Royo et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Analysis of filtration behavior using integrated column chromatography followed by virus filtration

(2021) Hironobu Shirataki et al.   BIOTECHNOLOGY AND BIOENGINEERING

Continuous capture of recombinant antibodies by ZnCl 2 precipitation without polyethylene glycol

(2020) Gregory Dutra et al.   ENGINEERING IN LIFE SCIENCES

High throughput solubility and redissolution screening for antibody purification via combined PEG and zinc chloride precipitation

(2020) Qin Gu et al.   BIOTECHNOLOGY PROGRESS

Automation of Dead End Filtration: An Enabler for Continuous Processing of Biotherapeutics

(2020) Garima Thakur et al.   Frontiers in Bioengineering and Biotechnology

Enhanced filtration performance using feed‐and‐bleed configuration for purification of antibody precipitates

(2020) Zhao Li et al.   BIOTECHNOLOGY PROGRESS

Continuous integrated antibody precipitation with two-stage tangential flow microfiltration enables constant mass flow

(2019) Daniel Burgstaller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Precipitation of complex antibody solutions: influence of contaminant composition and cell culture medium on the precipitation behavior

(2019) Steffen Großhans et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Application of the Bradford Assay for Cell Lysis Quantification: Residual Protein Content in Cell Culture Supernatants

(2019) Bernhard Sissolak et al.   Biotechnology Journal

Continuous Precipitation for Monoclonal Antibody Capture Using Countercurrent Washing by Microfiltration

(2019) Zhao Li et al.   BIOTECHNOLOGY PROGRESS

Fractal dimension of antibody‐PEG precipitate: Light microscopy for the reconstruction of 3D precipitate structures

(2019) Peter Satzer et al.   ENGINEERING IN LIFE SCIENCES

An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration

(2018) Steffen Großhans et al.   JOURNAL OF CHROMATOGRAPHY A

Water on hydrophobic surfaces: mechanistic modeling of polyethylene glycol-induced protein precipitation

(2018) Steffen Großhans et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Polishing approach with fully connected flow-through purification for therapeutic monoclonal antibody

(2018) Takamitsu Ichihara et al.   ENGINEERING IN LIFE SCIENCES

Purification of monoclonal antibodies entirely in flow-through mode

(2017) Tsuyoshi Yamada et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Pool-less processing to streamline downstream purification of monoclonal antibodies

(2016) Jennifer Zhang et al.   ENGINEERING IN LIFE SCIENCES

Continuous polyethylene glycol precipitation of recombinant antibodies: Sequential precipitation and resolubilization

(2016) Nikolaus Hammerschmidt et al.   PROCESS BIOCHEMISTRY

Capture and intermediate purification of recombinant antibodies with combined precipitation methods

(2015) Ralf Sommer et al.   BIOCHEMICAL ENGINEERING JOURNAL

A new, integrated, continuous purification process template for monoclonal antibodies: Process modeling and cost of goods studies

(2015) Alex Xenopoulos   JOURNAL OF BIOTECHNOLOGY

Branched polyethylene glycol for protein precipitation

(2011) Siow-Leng Sim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Protein precipitation by polyethylene glycol: A generalized model based on hydrodynamic radius

(2011) Siow-Leng Sim et al.   JOURNAL OF BIOTECHNOLOGY