Coupling of chromatography and precipitation for adjusting acidic variant content in a monoclonal antibody pool

Preferential precipitation of acidic variants from monoclonal antibody pools

(2022) Tomasz Rumanek et al.   BIOTECHNOLOGY AND BIOENGINEERING

A novel twin‐column continuous chromatography approach for separation and enrichment of monoclonal antibody charge variants

(2021) Shu‐Ying Jing et al.   ENGINEERING IN LIFE SCIENCES

Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach

(2021) Till Briskot et al.   JOURNAL OF CHROMATOGRAPHY A

Robust mechanistic modeling of protein ion-exchange chromatography

(2021) Vijesh Kumar et al.   JOURNAL OF CHROMATOGRAPHY A

Separation of charge variants of a monoclonal antibody by overloaded ion exchange chromatography

(2021) Krystian Baran et al.   JOURNAL OF CHROMATOGRAPHY A

Modulating cell culture oxidative stress reduces protein glycation and acidic charge variant formation

(2019) Stanley Chung et al.   mAbs

Cation exchange frontal chromatography for the removal of monoclonal antibody aggregates

(2019) Matthew T. Stone et al.   JOURNAL OF CHROMATOGRAPHY A

Selectivity enhanced cation exchange chromatography for simultaneous determination of peptide variants

(2019) Sameh Ahmed et al.   TALANTA

Separation of monoclonal antibody charge variants using cation exchange chromatography: Resins and separation conditions optimization

(2019) Shu-Ying Jing et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles

(2018) Stanley Chung et al.   BIOTECHNOLOGY AND BIOENGINEERING

Design of two-column batch-to-batch recirculation to enhance performance in ion-exchange chromatography

(2018) Oliver Persson et al.   JOURNAL OF CHROMATOGRAPHY A

Prediction tool for loading, isocratic elution, gradient elution and scaling up of ion exchange chromatography of proteins

(2018) Wojciech Kazimierz Marek et al.   JOURNAL OF CHROMATOGRAPHY A

Purification of antibody fragments for the reduction of charge variants using cation exchange chromatography

(2018) Hong Jai Lee et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Multi-column displacement chromatography for separation of charge variants of monoclonal antibodies

(2018) Ohnmar Khanal et al.   JOURNAL OF CHROMATOGRAPHY A

Determination of critical quality attributes for monoclonal antibodies using quality by design principles

(2016) Nadja Alt et al.   BIOLOGICALS

Microheterogeneity of therapeutic monoclonal antibodies is governed by changes in the surface charge of the protein

(2016) Beate Hintersteiner et al.   Biotechnology Journal

Evaluation of Heavy-Chain C-Terminal Deletion on Product Quality and Pharmacokinetics of Monoclonal Antibodies

(2016) Guoying Jiang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors

(2016) Beate Hintersteiner et al.   mAbs

Microheterogeneity of therapeutic monoclonal antibodies is governed by changes in the surface charge of the protein

(2016) Beate Hintersteiner et al.   Biotechnology Journal

Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part I: Salt gradient approach

(2015) Szabolcs Fekete et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part II: pH gradient approach

(2015) Szabolcs Fekete et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Therapeutic monoclonal antibodies and consistent ends: terminal heterogeneity, detection, and impact on quality

(2014) Kurt Brorson et al.   CURRENT OPINION IN BIOTECHNOLOGY

Early developability screen of therapeutic antibody candidates using Taylor dispersion analysis and UV area imaging detection

(2014) Alexandra Lavoisier et al.   mAbs

In vitro and in vivo modifications of recombinant and human IgG antibodies

(2014) Hongcheng Liu et al.   mAbs

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

(2014) Markus Haberger et al.   mAbs

Isolation of monoclonal antibody from a Chinese hamster ovary supernatant. II: Dynamics of the integrated separation on ion exchange and hydrophobic interaction chromatography media

(2013) Wojciech Marek et al.   JOURNAL OF CHROMATOGRAPHY A

Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins

(2012) Miranda M. C. van Beers et al.   Biotechnology Journal

Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies

(2012) Yi Du et al.   mAbs

Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography

(2011) Taylor Zhang et al.   JOURNAL OF CHROMATOGRAPHY A

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

(2010) C. Andrew Boswell et al.   BIOCONJUGATE CHEMISTRY

Separation of oxidized variants of a monoclonal antibody by anion-exchange

(2010) Glen Teshima et al.   JOURNAL OF CHROMATOGRAPHY A

Charge variants in IgG1

(2010) Leslie A. Khawli et al.   mAbs

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Binary adsorption of globular proteins on ion-exchange media

(2009) Xuankuo Xu et al.   JOURNAL OF CHROMATOGRAPHY A

Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP)

(2008) Thomas Müller-Späth et al.   BIOTECHNOLOGY AND BIOENGINEERING