Therapeutic Approaches Targeting Ferroptosis in Cardiomyopathy

Regulated cell death pathways in cardiomyopathy

(2023) Shu-yuan Sheng et al.   ACTA PHARMACOLOGICA SINICA

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

(2023) Tomonori Tadokoro et al.   JCI Insight

Cell death regulation in myocardial toxicity induced by antineoplastic drugs

(2023) Xue Yu et al.   Frontiers in Cell and Developmental Biology

Activation of NRF2/FPN1 pathway attenuates myocardial ischemia–reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis

(2022) Hao Tian et al.   CELL STRESS & CHAPERONES

PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway

(2022) Yilong Wang et al.   CELL DEATH AND DIFFERENTIATION

Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis

(2022) Qi Zhang et al.   Frontiers in Cell and Developmental Biology

Post-Translational Modification of GPX4 is a Promising Target for Treating Ferroptosis-Related Diseases

(2022) Can Cui et al.   Frontiers in Molecular Biosciences

Exploring the Communal Pathogenesis, Ferroptosis Mechanism, and Potential Therapeutic Targets of Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy via a Microarray Data Analysis

(2022) Zuoxiang Wang et al.   Frontiers in Cardiovascular Medicine

The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

(2022) Xuexian Fang et al.   Nature Reviews Cardiology

Ferroptosis and its role in cardiomyopathy

(2022) Danlei Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Iron-dependent ferroptosis participated in benzene-induced anemia of inflammation through IRP1-DHODH-ALOX12 axis

(2022) Wei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy

(2022) Na Ta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Research Progress of Chinese Medicine in the Treatment of Myocardial Ischemia–Reperfusion Injury

(2022) Li Dong et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

TIPE2 knockout reduces myocardial cell damage by inhibiting IFN-γ-mediated ferroptosis

(2022) Yan Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cellular degradation systems in ferroptosis

(2021) Xin Chen et al.   CELL DEATH AND DIFFERENTIATION

Saponins in Chinese Herbal Medicine Exerts Protection in Myocardial Ischemia–Reperfusion Injury: Possible Mechanism and Target Analysis

(2021) Ruiying Wang et al.   Frontiers in Pharmacology

Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling

(2021) Li-Fei Luo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Protective Effect of Cyanidin-3-Glucoside on Myocardial Ischemia-Reperfusion Injury through Ferroptosis

(2021) Xin Shan et al.   Oxidative Medicine and Cellular Longevity

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis

(2021) Zhenyu Fan et al.   Frontiers in Pharmacology

Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications

(2021) Yuhan Qin et al.   BIOMEDICINE & PHARMACOTHERAPY

Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease

(2021) Archita Venugopal Menon et al.   BLOOD

SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis

(2021) Xiyu Zhang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Cardiomyopathies: An Overview

(2021) Tiziana Ciarambino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

(2021) Kai Hou et al.   EBioMedicine

Lipid Metabolism in Ferroptosis

(2021) Zhi Lin et al.   Advanced Biology

Tanshinone IIA protects human coronary artery endothelial cells from ferroptosis by activating the NRF2 pathway

(2021) Lina He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The molecular mechanisms of ferroptosis and its role in cardiovascular disease

(2021) Yang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis

(2021) Ting Li et al.   GENE

MITOL/MARCH5 determines the susceptibility of cardiomyocytes to doxorubicin-induced ferroptosis by regulating GSH homeostasis

(2021) Hiroki Kitakata et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

(2021) Xiang Wang et al.   Acta Pharmaceutica Sinica B

The Role of Ferroptosis in Cardiovascular Disease and Its Therapeutic Significance

(2021) Zhenzhen Chen et al.   Frontiers in Cardiovascular Medicine

Development of a highly efficient and specific l-theanine synthase

(2020) Jun Yao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

AIFM2 blocks ferroptosis independent of ubiquinol metabolism

(2020) Enyong Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis

(2020) Kamyar Hadian   BIOCHEMISTRY

Iron metabolism and iron disorders revisited in the hepcidin era

(2020) Clara Camaschella et al.   HAEMATOLOGICA

Dexrazoxane Protects Cardiomyocyte from Doxorubicin-Induced Apoptosis by Modulating miR-17-5p

(2020) Xiaoxue Yu et al.   Biomed Research International

Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction

(2020) Bita Behrouzi et al.   BASIC RESEARCH IN CARDIOLOGY

Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

(2020) Yu-Jing He et al.   BIOMATERIALS

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis and Its Potential Role in Human Diseases

(2020) Chu Han et al.   Frontiers in Pharmacology

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma

(2020) Ji Feng et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

(2020) Tao Bai et al.   FREE RADICAL BIOLOGY AND MEDICINE

An overview of lipoxygenase inhibitors with approach of in vivo studies

(2020) Ala Orafaie et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Sterile inflammation in thoracic transplantation

(2020) C. Corbin Frye et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia‐reperfusion

(2020) Yixin Xu et al.   FASEB JOURNAL

Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition

(2020) Yunchang Liu et al.   Cell Death & Disease

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

(2020) Bo Yan et al.   MOLECULAR CELL

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

(2019) Javier Garcia-Bermudez et al.   NATURE

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary

(2019) Donna K. Arnett et al.   CIRCULATION

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

(2019) Wenjun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis

(2019) Qin Li et al.   Frontiers in Pharmacology

Delayed time from RBC transfusion dependence to first cardiac event in lower IPSS risk MDS patients receiving iron chelation therapy

(2019) Colleen A.C. Wong et al.   LEUKEMIA RESEARCH

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

(2019) Dominic P. Del Re et al.   PHYSIOLOGICAL REVIEWS

Redox-dependent gating of VDAC by mitoNEET

(2019) Colin H. Lipper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1

(2019) Hironari Nishizawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

(2019) Lian-Jiu Su et al.   Oxidative Medicine and Cellular Longevity

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

(2019) Tae-Jun Park et al.   Cell Death & Disease

Curcumin, Hormesis and the Nervous System

(2019) Maria Concetta Scuto et al.   Nutrients

Characterization of Lipid Profiles after Dietary Intake of Polyunsaturated Fatty Acids Using Integrated Untargeted and Targeted Lipidomics

(2019) Satoko Naoe et al.   Metabolites

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

(2019) Yansheng Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation

(2019) Sofia-Iris Bibli et al.   Redox Biology

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

(2018) Bei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ENPP2 protects cardiomyocytes from erastin-induced ferroptosis

(2018) Yu-Ting Bai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells

(2018) David N. DeHart et al.   BIOCHEMICAL PHARMACOLOGY

Effects of the iron chelator deferiprone and the T-type calcium channel blocker efonidipine on cardiac function and Ca 2+ regulation in iron-overloaded thalassemic mice

(2018) Juthamas Khamseekaew et al.   CELL CALCIUM

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Anti-Cancer Compounds Targeted to VDAC: Potential and Perspectives

(2018) Simona Reina et al.   CURRENT MEDICINAL CHEMISTRY

Cysteine Metabolism in Neuronal Redox Homeostasis

(2018) Bindu D. Paul et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

(2018) Andrew Hinman et al.   PLoS One

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

(2018) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recent Developments on the Crosstalk Between STAT3 and Inflammation in Heart Function and Disease

(2018) Mazen Kurdi et al.   Frontiers in Immunology

Anthracycline cardiotoxicity: an update on mechanisms, monitoring and prevention

(2017) Peter A Henriksen   HEART

The α6β4 integrin promotes resistance to ferroptosis

(2017) Caitlin W. Brown et al.   JOURNAL OF CELL BIOLOGY

Icariin protects against ischemia‑reperfusion injury in H9C2 cells by upregulating heat shock protein 20

(2017) Zhi‑Hong Ren et al.   Molecular Medicine Reports

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats

(2017) Nawal M. Al-Rasheed et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy

(2016) Junlian Gu et al.   DIABETES

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Cardiotoxicity of anticancer treatments

(2015) Michael S. Ewer et al.   Nature Reviews Cardiology

The iron-regulatory hormone hepcidin: A possible therapeutic target?

(2015) Luc Rochette et al.   PHARMACOLOGY & THERAPEUTICS

Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

(2015) Edna Ooko et al.   PHYTOMEDICINE

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

(2015) Lalage A. Katunga et al.   Molecular Metabolism

Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury

(2014) Weidong Qian et al.   Evidence-based Complementary and Alternative Medicine

Association of Genetic Polymorphisms for Glutathione Peroxidase Genes with Obesity in Spanish Children

(2014) Azahara I. Rupérez et al.   Journal of Nutrigenetics and Nutrigenomics

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Mammalian target of rapamycin coordinates iron metabolism with iron-sulfur cluster assembly enzyme and tristetraprolin

(2014) Peng Guan et al.   NUTRITION

Cardiovascular Function and Treatment in β-Thalassemia Major

(2013) Dudley J. Pennell et al.   CIRCULATION

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Puerarin: A Review of Pharmacological Effects

(2013) Yan-Xi Zhou et al.   PHYTOTHERAPY RESEARCH

Cardiac mTOR protects the heart against ischemia-reperfusion injury

(2012) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin

(2012) Marina Bayeva et al.   Cell Metabolism

Novel correlations between the genotype and the phenotype of hypertrophic and dilated cardiomyopathy: results from the German Competence Network Heart Failure

(2011) Stephan Waldmüller et al.   EUROPEAN JOURNAL OF HEART FAILURE

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice

(2010) Wei-Jian Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Iron Overload Cardiomyopathy

(2010) Pradeep Gujja et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dilated cardiomyopathy

(2010) John Lynn Jefferies et al.   LANCET

Cardiotoxicity of anticancer treatments: what the cardiologist needs to know

(2010) Michael S. Ewer et al.   Nature Reviews Cardiology

Diagnostic, Prognostic, and Therapeutic Implications of Genetic Testing for Hypertrophic Cardiomyopathy

(2009) J. Martijn Bos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondria-specific transgenic overexpression of phospholipid hydroperoxide glutathione peroxidase (GPx4) attenuates ischemia/reperfusion-associated cardiac dysfunction

(2008) Erinne R. Dabkowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron-binding and anti-Fenton properties of baicalein and baicalin

(2008) Carlos A. Perez et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes

(2008) Xiao Hu Ge et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Interaction of anthracyclines with iron responsive element mRNAs

(2008) Joshua C. Canzoneri et al.   NUCLEIC ACIDS RESEARCH