标题
Mouse models of Down syndrome: gene content and consequences
作者
关键词
Down Syndrome, Morris Water Maze, Context Fear Conditioning, Preclinical Evaluation, Partial Trisomy
出版物
MAMMALIAN GENOME
Volume 27, Issue 11-12, Pages 538-555
出版商
Springer Nature
发表日期
2016-08-18
DOI
10.1007/s00335-016-9661-8
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome
- (2016) J. W. Goodliffe et al. JOURNAL OF NEUROSCIENCE
- Treating trisomies: Prenatal Down's syndrome therapies explored in mice
- (2016) Bridget M. Kuehn NATURE MEDICINE
- Chromosome 21-derived hsa-miR-155-5p regulates mitochondrial biogenesis by targeting Mitochondrial Transcription Factor A (TFAM)
- (2015) Adolfo Quiñones-Lombraña et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges
- (2015) Xavier Bofill-De Ros et al. BMC GENOMICS
- Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology
- (2015) Elizabeth Head et al. Current Alzheimer Research
- A LncRNA-MAF:MAFB Transcription Factor Network Regulates Epidermal Differentiation
- (2015) Vanessa Lopez-Pajares et al. DEVELOPMENTAL CELL
- Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation
- (2015) S. C. Warth et al. EMBO JOURNAL
- 21q21 deletion involving NCAM2: Report of 3 cases with neurodevelopmental disorders
- (2015) Florence Petit et al. European Journal of Medical Genetics
- Genetic dissection of the Down syndrome critical region
- (2015) Xiaoling Jiang et al. HUMAN MOLECULAR GENETICS
- New Perspectives for the Rescue of Cognitive Disability in Down Syndrome
- (2015) R. Bartesaghi et al. JOURNAL OF NEUROSCIENCE
- Devising a Consensus Framework for Validation of Novel Human Coding Loci
- (2015) Elspeth A. Bruford et al. JOURNAL OF PROTEOME RESEARCH
- Paradigm shifts in genomics through the FANTOM projects
- (2015) Michiel de Hoon et al. MAMMALIAN GENOME
- Discovery and characterization of smORF-encoded bioactive polypeptides
- (2015) Alan Saghatelian et al. Nature Chemical Biology
- Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
- (2015) Elena Zenaro et al. NATURE MEDICINE
- Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation
- (2015) Nuala A. O'Leary et al. NUCLEIC ACIDS RESEARCH
- Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain
- (2015) Loyal A. Goff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function
- (2015) Juhyun Song et al. Frontiers in Aging Neuroscience
- Dissecting Alzheimer disease in Down syndrome using mouse models
- (2015) Xun Yu Choong et al. Frontiers in Behavioral Neuroscience
- Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models
- (2015) Benoit Souchet et al. Frontiers in Behavioral Neuroscience
- Opposite Phenotypes of Muscle Strength and Locomotor Function in Mouse Models of Partial Trisomy and Monosomy 21 for the Proximal Hspa13-App Region
- (2015) Véronique Brault et al. PLoS Genetics
- Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome
- (2015) Aaron Block et al. Biology of Sex Differences
- Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues
- (2015) Pavel V. Belichenko et al. PLoS One
- Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice
- (2014) John M. Starbuck et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Knocking down CDK4 mediates the elevation of let-7c suppressing cell growth in nasopharyngeal carcinoma
- (2014) Zhen Liu et al. BMC CANCER
- miR-99a directly targets the mTOR signalling pathway in breast cancer side population cells
- (2014) Z. Yang et al. CELL PROLIFERATION
- Long Noncoding RNAs in Cell-Fate Programming and Reprogramming
- (2014) Ryan A. Flynn et al. Cell Stem Cell
- DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies
- (2014) Walter Becker et al. CNS & Neurological Disorders-Drug Targets
- Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1
- (2014) X. Su et al. GENES & DEVELOPMENT
- miR-99a Suppresses the Metastasis of Human Non-Small Cell Lung Cancer Cells by Targeting AKT1 Signaling Pathway
- (2014) Shi-huan Yu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Novel Long Noncoding RNAs (lncRNAs) in Myogenesis: amiR-31Overlapping lncRNA Transcript Controls Myoblast Differentiation
- (2014) Monica Ballarino et al. MOLECULAR AND CELLULAR BIOLOGY
- LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia
- (2014) Stephan Emmrich et al. Molecular Cancer
- Design animal studies better
- (2014) Malcolm R. Macleod NATURE
- Preclinical research: Make mouse studies work
- (2014) Steve Perrin NATURE
- Emerging evidence for functional peptides encoded by short open reading frames
- (2014) Shea J. Andrews et al. NATURE REVIEWS GENETICS
- Genenames.org: the HGNC resources in 2015
- (2014) Kristian A. Gray et al. NUCLEIC ACIDS RESEARCH
- Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome
- (2014) Susana García-Cerro et al. PLoS One
- Physiological roles of long noncoding RNAs: insight from knockout mice
- (2014) Lingjie Li et al. TRENDS IN CELL BIOLOGY
- Transcriptional regulatory functions of nuclear long noncoding RNAs
- (2014) Keith W. Vance et al. TRENDS IN GENETICS
- Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations
- (2014) Katheleen Gardiner Drug Design Development and Therapy
- Animal models of human disease: Challenges in enabling translation
- (2013) Paul McGonigle et al. BIOCHEMICAL PHARMACOLOGY
- Animal models of CNS disorders
- (2013) Paul McGonigle BIOCHEMICAL PHARMACOLOGY
- MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways
- (2013) N Wu et al. BRITISH JOURNAL OF CANCER
- MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3
- (2013) Bingtian Zhao et al. CANCER LETTERS
- Long non-coding RNAs: modulators of nuclear structure and function
- (2013) Jan H Bergmann et al. CURRENT OPINION IN CELL BIOLOGY
- Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits
- (2013) L. Zhang et al. HUMAN MOLECULAR GENETICS
- ADAR Enzyme and miRNA Story: A Nucleotide that Can Make the Difference
- (2013) Sara Tomaselli et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Chaperone Stress 70 Protein (STCH) Binds and Regulates Two Acid/Base Transporters NBCe1-B and NHE1
- (2013) Jun-Seok Bae et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Modulation of NMDAR Subunit Expression by TRPM2 Channels Regulates Neuronal Vulnerability to Ischemic Cell Death
- (2013) I. Alim et al. JOURNAL OF NEUROSCIENCE
- The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis
- (2013) Shi-Yan Ng et al. MOLECULAR CELL
- Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans
- (2013) Rafael De la Torre et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation
- (2013) Wenbo Li et al. NATURE
- The Vertebrate Genome Annotation browser 10 years on
- (2013) Jennifer L. Harrow et al. NUCLEIC ACIDS RESEARCH
- Ensembl 2014
- (2013) Paul Flicek et al. NUCLEIC ACIDS RESEARCH
- Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome
- (2013) Susan M. Gribble et al. PLoS One
- Sorting Nexin 9 Recruits Clathrin Heavy Chain to the Mitotic Spindle for Chromosome Alignment and Segregation
- (2013) Maggie P. C. Ma et al. PLoS One
- miR-125b Acts as a Tumor Suppressor in Breast Tumorigenesis via Its Novel Direct Targets ENPEP, CK2-α, CCNJ, and MEGF9
- (2013) Andrea Feliciano et al. PLoS One
- Multiple knockout mouse models reveal lincRNAs are required for life and brain development
- (2013) Martin Sauvageau et al. eLife
- MicroRNAs and lymphomagenesis: a functional review
- (2012) Charles H. Lawrie BRITISH JOURNAL OF HAEMATOLOGY
- The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression
- (2012) T. Derrien et al. GENOME RESEARCH
- GENCODE: The reference human genome annotation for The ENCODE Project
- (2012) J. Harrow et al. GENOME RESEARCH
- Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial
- (2012) Marisa Hanney et al. LANCET
- Raise standards for preclinical cancer research
- (2012) C. Glenn Begley et al. NATURE
- Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP
- (2012) Katja S. Kroker et al. NEUROPHARMACOLOGY
- Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome
- (2012) V. Vidal et al. NEUROSCIENCE
- Correlation of increased hippocampal Sumo3 with spatial learning ability in old C57BL/6 mice
- (2012) Qi-Gang Yang et al. NEUROSCIENCE LETTERS
- TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death
- (2012) S. Verma et al. NEUROSCIENCE LETTERS
- ENCODE Data in the UCSC Genome Browser: year 5 update
- (2012) Kate R. Rosenbloom et al. NUCLEIC ACIDS RESEARCH
- Melatonin modulates apoptosis and TRPM2 channels in transfected cells activated by oxidative stress
- (2012) Ömer Çelik et al. PHYSIOLOGY & BEHAVIOR
- Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice
- (2012) A. Cooper et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Snapin Recruits Dynein to BDNF-TrkB Signaling Endosomes for Retrograde Axonal Transport and Is Essential for Dendrite Growth of Cortical Neurons
- (2012) Bing Zhou et al. Cell Reports
- Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities
- (2012) Noemí Rueda et al. NEURAL PLASTICITY
- Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial
- (2012) R Boada et al. Translational Psychiatry
- Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation
- (2011) Ira T. Lott et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
- (2011) Dun-Sheng Yang et al. Autophagy
- Neuropeptide Trefoil factor 3 improves learning and retention of novel object recognition memory in mice
- (2011) Hai-Shui Shi et al. BEHAVIOURAL BRAIN RESEARCH
- NCAM2/OCAM/RNCAM: Cell adhesion molecule with a role in neuronal compartmentalization
- (2011) Malene Winther et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice
- (2011) Marion Horsch et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sex Differences in Neuroprotection Provided by Inhibition of TRPM2 Channels following Experimental Stroke
- (2011) Jia Jia et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions
- (2011) Xiaolu Sturgeon et al. MAMMALIAN GENOME
- Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome
- (2011) Arnaud Duchon et al. MAMMALIAN GENOME
- The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents
- (2011) P.H. Hutson et al. NEUROPHARMACOLOGY
- S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors
- (2011) Jie Lu et al. PLoS One
- Dynein Light Chain Tctex-Type 1 Modulates Orexin Signaling through Its Interaction with Orexin 1 Receptor
- (2011) David Duguay et al. PLoS One
- Dependence of NMDA/GSK-3β Mediated Metaplasticity on TRPM2 Channels at Hippocampal CA3-CA1 Synapses
- (2011) Yu-Feng Xie et al. Molecular Brain
- Endostatin binds nerve growth factor and thereby inhibits neurite outgrowth and neuronal migration in-vitro
- (2010) Abraham Al Ahmad et al. BRAIN RESEARCH
- Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice
- (2010) Tao Yu et al. BRAIN RESEARCH
- Disruption of Protein Arginine N -Methyltransferase 2 Regulates Leptin Signaling and Produces Leanness In Vivo Through Loss of STAT3 Methylation
- (2010) Hiroaki Iwasaki et al. CIRCULATION RESEARCH
- β-Catenin Primes Organizer Gene Expression by Recruiting a Histone H3 Arginine 8 Methyltransferase, Prmt2
- (2010) Shelby A. Blythe et al. DEVELOPMENTAL CELL
- Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides
- (2010) Nada Choucair-Jaafar et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
- A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions
- (2010) Tao Yu et al. HUMAN MOLECULAR GENETICS
- Increased male reproductive success in Ts65Dn “Down syndrome” mice
- (2010) Clara S. Moore et al. MAMMALIAN GENOME
- Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
- (2010) Rajnish A. Gupta et al. NATURE
- miR-155 gene: A typical multifunctional microRNA
- (2009) Isabella Faraoni et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- A new mouse model for the trisomy of the Abcg1–U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome
- (2009) Patricia Lopes Pereira et al. HUMAN MOLECULAR GENETICS
- The mammalian anti-proliferative BTG/Tob protein family
- (2009) G. Sebastiaan Winkler JOURNAL OF CELLULAR PHYSIOLOGY
- Long non-coding RNAs: insights into functions
- (2009) Tim R. Mercer et al. NATURE REVIEWS GENETICS
- The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies
- (2009) J. O. Korbel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- S100B's double life: Intracellular regulator and extracellular signal
- (2008) Rosario Donato et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Twenty-year trends in prevalence and survival of Down syndrome
- (2008) Claire Irving et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Long intronic noncoding RNA transcription: Expression noise or expression choice?
- (2008) Rodrigo Louro et al. GENOMICS
- Vitamin E increases S100B-mediated microglial activation in an S100B-overexpressing mouse model of pathological aging
- (2008) Lynn A. Bialowas-McGoey et al. GLIA
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