Article
Food Science & Technology
Fang Zhao, Xiaohan Zou, Shaoheng Li, Jing He, Chuchu Xi, Qinglian Tang, Yujing Wang, Zhengyu Cao
Summary: The research identified a new scorpion toxin, BmK NSPK, which enhances neurite extension through increasing the release of nerve growth factor and TrkA signaling pathway. This provides a new theoretical basis for developing treatments for spinal cord neuron development and regeneration using K-v channels.
Article
Engineering, Electrical & Electronic
Bjarke Norrehvedde Jensen, Yuting Wang, Alice Le Friec, Sadegh Nabavi, Mingdong Dong, Dror Seliktar, Menglin Chen
Summary: A wireless electromagnetic neural stimulation patch has been developed, which combines electromagnetic induction and physical guidance cues to promote neural cell growth and treat neurological diseases. In vitro experiments confirmed the biocompatibility and efficacy of the patch's electromagnetic stimulation in promoting neurite outgrowth, demonstrating its great potential for non-invasive neurological therapeutics.
NPJ FLEXIBLE ELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Marta R. Casanova, Rui L. Reis, Albino Martins, Nuno M. Neves
Summary: A biofunctional electrospun fibrous mesh (eFM) was developed by selectively retrieving nerve growth factor (NGF) from rat blood plasma, which can enhance neurite outgrowth and promote neuronal differentiation for peripheral nerve injury.
Article
Chemistry, Multidisciplinary
Oana Dobre, Mariana A. G. Oliva, Giuseppe Ciccone, Sara Trujillo, Aleixandre Rodrigo-Navarro, Douglas Cormac Venters, Virginia Llopis-Hernandez, Massimo Vassalli, Cristina Gonzalez-Garcia, Matthew J. Dalby, Manuel Salmeron-Sanchez
Summary: Laminins are crucial structural proteins in the ECM that bind growth factors and play tissue-specific roles. A new LM-PEG hydrogel platform inspired by Matrigel offers controlled stiffness and degradability, enabling specific targeting of tissues through GFs presented at ultralow doses. This platform demonstrates the potential to induce stem cell differentiation and promote neural cell growth in a synthetic, reproducible 3D microenvironment mimicking the native ECM.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Gabrielle Edwards, Taaliah Campbell, Veronica Henderson, Alira Danaher, Daqing Wu, Rekha Srinivasan, Khosrow Rezvani, Valerie A. Odero-Marah
Summary: The study demonstrates that prostate cancer cells promote migration and adhesion to nerve cells through Snail expression, as well as neurite outgrowth via secretion of soluble factors. Targeting cancer cell interaction with nerves may be a potential strategy to halt prostate cancer progression/metastasis.
Article
Multidisciplinary Sciences
Anna-Kathrine Pedersen, Anamarija Pfeiffer, Gopal Karemore, Vyacheslav Akimov, Dorte B. Bekker-Jensen, Blagoy Blagoev, Chiara Francavilla, Jesper Olsen
Summary: This study investigated the roles of E3 ubiquitin ligases Cbl and Cbl-b in regulating signaling responses associated with neuroblastoma cell differentiation. By using mass spectrometry-based proteomics, the study identified SHP-2 and CDK16 as key regulators of extracellular signal-regulated kinase phosphorylation and neurite outgrowth in neuroblastoma, highlighting their involvement in the differentiation process.
Article
Chemistry, Multidisciplinary
D. Merryweather, S. R. Moxon, A. J. Capel, N. M. Hooper, M. P. Lewis, P. Roach
Summary: Cellular metabolism and behaviour are closely linked to cytoskeletal tension and scaffold mechanics. In this study, a 3D culture system using diluted type I collagen hydrogel to produce variation in gel stiffness was explored. The results showed that hydrogel scaffold remodelling was linked to gel collagen concentration and different concentrations of gel led to significant changes in programmed cell behaviour and cell morphology.
Article
Nanoscience & Nanotechnology
Wen Xue, Yunfan Kong, Rafay Abu, Pooja Roy, Sung-Ho Huh, Mitchell Kuss, Vikas Kumar, Bin Duan
Summary: Decellularized nerve hydrogels (dNHs) have shown promising effects on promoting Schwann cell proliferation and neurite outgrowth. The mechanics and components of the hydrogel contribute to its functionality, with laminin (LAM) and type V collagen (COLV) playing important roles. Additionally, by adding LAM and COLV to collagen hydrogels, gene expression of Schwann cells can be regulated, leading to improved spreading and neurite outgrowth. Furthermore, dNHs can be fabricated into paper-like, aligned nerve scaffolds for peripheral nerve injury treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Tabitha N. Rosenbalm, Nicole H. Levi, Michael J. Morykwas, William D. Wagner
Summary: In this study, bioresorbable materials capable of producing electric field gradients were developed to assess their impact on neuronal cell growth and migration. The results showed that the biphasic conductive composites can maintain nerve mechanical properties while promoting neuronal cell growth. Tubular conduits composed of these materials were found to be superior to silicone conduits for nerve repair.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Chuankai Dai, Xiaoming Liu, Rongyu Tang, Jiping He, Tatsuo Arai
Summary: In recent years, microfluidics has been crucial to the advancement of nerve regeneration research. Microfluidic devices accurately simulate the in vivo microenvironment for various research purposes such as analyzing growth inhibitory factors, screening drugs, evaluating nerve growth factors, and investigating neural injury and regeneration mechanisms. The platform enables precise control of cell behavior, such as neuron isolation, single-cell manipulation, neural patterning, and axon guidance, providing technical support for nerve regeneration.
APPLIED SCIENCES-BASEL
(2022)
Article
Cell Biology
Hyo-Jeong Yong, Jong-Ik Hwang, Jae-Young Seong
Summary: This study highlights the critical role of FAM19A1 in neuronal maturation and function by affecting dendritic spine development and neurite arborization, demonstrating its involvement in maintaining neural integrity and connectivity.
Article
Plant Sciences
Jin A. Jung, Heon Joo Lee, Myoung Chong Song, Areum Hwangbo, Ji Yoon Beom, Soo Jung Lee, Dong Jin Park, Ji Hoon Oh, Sang-Jun Ha, Eunji Cheong, Yeo Joon Yoon
Summary: Separating the immunosuppressive activity of FK506 from its neurotrophic activity, two new FK506 analogues were synthesized with a proline substitution, which significantly reduced immunosuppressive activity while retaining neurotrophic activity. This replacement is critical for enhancing neurotrophic activity while reducing strong immunosuppressive activity.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Medicine, Research & Experimental
Issa Olakunle Yusuf, Hsiu-Mei Chen, Pei-Hsun Cheng, Chih-Yi Chang, Shaw-Jenq Tsai, Jih-Ing Chuang, Chia-Ching Wu, Bu-Miin Huang, H. Sunny Sun, Chuan-Mu Chen, Shang-Hsun Yang
Summary: This study demonstrates the importance of the ERK pathway in FGF9-induced neurite outgrowth in HD striatal models. Suppression of ERK signaling inhibits neurite outgrowth, cytoskeletal markers, and synaptic proteins, as well as NF-kB activation induced by FGF9. These findings suggest a sequential activation mechanism where FGF9 first activates the ERK signaling pathway, leading to NF-kB upregulation and subsequent enhancement of neurite outgrowth in HD striatal cells.
Article
Food Science & Technology
Alex Xiong Gao, Jian Xiao, Tracy Chen-Xi Xia, Tina Ting-Xia Dong, Karl Wah-Keung Tsim
Summary: The ethanolic extract of peanut shell, known as PSE, is enriched with flavonoids that have neurotrophic functions. PSE can promote cell differentiation and neurofilament synthesis by activating the ERK1/2 and Akt signaling pathways. Phytochemicals such as luteolin, eriodictyol, and 5,7-dihydroxychromone in PSE may contribute to its neurotrophic effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Tamara Mengis, Nick Herger, Irina Heggli, Jan Devan, Jose Miguel Spirig, Christoph J. Laux, Florian Brunner, Mazda Farshad, Oliver Distler, Stefan Dudli
Summary: This study investigated the role of MC1 BMSCs in neurite outgrowth and found that MC1 BMSCs could produce various neurotrophic factors to promote neurite sprouting. Co-culture experiments of MC1 BMSCs with neuroblastoma cells further confirmed this finding.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Neurosciences
Abraham J. Al-Ahmad, Boyeon Lee, Maxim Saini, Gregory J. Bix
Article
Biophysics
Omolara O. Ogunshola, Abraham Al-Ahmad
HIGH ALTITUDE MEDICINE & BIOLOGY
(2012)
Article
Cell Biology
A. Al Ahmad, M. Gassmann, O. O. Ogunshola
JOURNAL OF CELLULAR PHYSIOLOGY
(2009)
Article
Endocrinology & Metabolism
Abraham Al Ahmad, Carole Buergi Taboada, Max Gassmann, Omolara O. Ogunshola
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2011)
Article
Medicine, Research & Experimental
Boyeon Lee, Douglas Clarke, Abraham Al Ahmad, Michael Kahle, Christi Parham, Lisa Auckland, Courtney Shaw, Mehmet Fidanboylu, Anthony Wayne Orr, Omolara Ogunshola, Andrzej Fertala, Sarah A. Thomas, Gregory J. Bix
JOURNAL OF CLINICAL INVESTIGATION
(2011)
Correction
Medicine, Research & Experimental
Boyeon Lee, Douglas Clarke, Abraham Al Ahmad, Michael Kahle, Christi Parham, Lisa Auckland, Courtney Shaw, Mehmet Fidanboylu, Anthony Wayne Orr, Omolara Ogunshola, Andrzej Fertala, Sarah A. Thomas, Gregory J. Bix
JOURNAL OF CLINICAL INVESTIGATION
(2012)
Article
Pharmacology & Pharmacy
Meriem Nait Chabane, Abraham Al Ahmad, Jean Peluso, Christian D. Muller, Genevieve Ubeaud
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2009)
Article
Peripheral Vascular Disease
Abraham Al Ahmad, Max Gassmann, Omolara O. Ogunshola
MICROVASCULAR RESEARCH
(2012)
Article
Biotechnology & Applied Microbiology
Ethan S. Lippmann, Samira M. Azarin, Jennifer E. Kay, Randy A. Nessler, Hannah K. Wilson, Abraham Al-Ahmad, Sean P. Palecek, Eric V. Shusta
NATURE BIOTECHNOLOGY
(2012)
Article
Multidisciplinary Sciences
Douglas N. Clarke, Abraham Al Ahmad, Boyeon Lee, Christi Parham, Lisa Auckland, Andrezj Fertala, Michael Kahle, Courtney S. Shaw, Jill Roberts, Gregory J. Bix
Review
Neurosciences
Ethan S. Lippmann, Abraham Al-Ahmad, Sean P. Palecek, Eric V. Shusta
FLUIDS AND BARRIERS OF THE CNS
(2013)
Meeting Abstract
Neurosciences
O. Ogunshola, A. Al Ahmad
Article
Pharmacology & Pharmacy
H. A. Milanei, A. Al Ahmad, M. Naitchabane, T. F. Vandamme, L. Jung, Genevieve Ubeaud
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2007)
Meeting Abstract
Physiology
Carole Buergi Taboada, Abraham Al Ahmad, Max Gassmann, Omolara Ogunshola
JOURNAL OF VASCULAR RESEARCH
(2009)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.