Review
Immunology
Julia N. Khantakova, Sergey V. Sennikov
Summary: The collaboration of various disciplines seeks to find new methods to cure impaired body functions through repairing, replacing, or regenerating cells, tissues, or organs. The possibility of reprogramming stable differentiated cells opens doors to new therapeutic strategies against diseases caused by the loss or dysfunction of specific cells. Understanding the factors that contribute to T cell plasticity is not only clinically important but also improves the knowledge of cell differentiation and developmental biology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Daniil Shevyrev, Valeriy Tereshchenko, Elena Blinova, Nadezda Knauer, Ekaterina Pashkina, Alexey Sizikov, Vladimir Kozlov
Summary: The study revealed that the proliferation of Treg cells in patients with rheumatoid arthritis under HP cytokine stimulation is lower compared to healthy individuals, and the suppressive activity decreases, which may lead to the proliferation of self-reactive T cell clones.
Review
Immunology
Kai Yang
Summary: Regulatory T cells (Tregs) play important roles in immune regulation, and cellular metabolism is crucial for their function. Tregs reprogram cellular metabolic programs to sustain their suppressive function, and altered metabolism also influences Treg activation and function. Manipulation of systemic metabolites has emerged as an attractive strategy to modulate tissue Treg metabolism and improve treatment of immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tyler C. Moore, Kim J. Hasenkrug
Summary: B lymphocytes play important roles during viral infections by producing antibodies, acting as antigen-presenting cells, regulating immune responses, and inducing Tregs. In the Friend virus model, Tregs inhibit effector CD8+ T-cell responses and contribute to virus persistence. Research focuses on the interactions between B cells and Tregs during FV infection.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Immunology
Yaroslav Kaminskiy, Varvara Kuznetsova, Anna Kudriaeva, Ekaterina Zmievskaya, Emil Bulatov
Summary: This review focuses on the role of FOXP1 in T-cells and reveals its crucial involvement in maintaining T-cell quiescence, CD4+ subset differentiation, as well as memory potential and exhaustion of T-cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Dandan Yang, Xueqiang Zhao, Xin Lin
Summary: Bcl10 plays a critical role in the development and function of regulatory T (Treg) cells, deficiency of which leads to impaired development and suppressive function of Treg cells, even causing lethal autoimmunity. Bcl10-deficient Treg cells can undergo conversion into proinflammatory cells and decrease in effector Treg cell populations. The study provides genetic evidence that Bcl10 is essential for Treg cell development and function.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Reiko Hidaka, Kazuko Miyazaki, Masaki Miyazaki
Summary: Immune responses are primarily mediated by adaptive and innate immune cells, which are activated through antigen recognition and regulated by a transcription factor network. The transcriptional balance between E and Id proteins plays a critical role in regulating the developmental trajectories of T and B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sung-Min Hwang, Sin-Hyeog Im, Dipayan Rudra
Summary: E and ID proteins play crucial roles in T cell development and function, influencing the differentiation and fate of T cells in multiple immune compartments. Understanding the endogenous proteins and signaling pathways that affect the dynamics of the E-ID axis is essential for a comprehensive understanding of T cell biology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Haoyuan Yu, Guohui Chen, Tao Zhang, Xin Huang, Yabin Lu, Maolin Li, Shuxian Li, Caiying Wang, Baoyu Li, Yunhang Zhang, Guangliang Liu, Yuguang Fu
Summary: PEDV promotes maturation of CD103+DCs and drives differentiation of CD4+T cells towards Th1, Tfh, and Treg cells.
Article
Immunology
Florianne M. J. Hafkamp, Esther W. M. Taanman-Kueter, Toni M. M. van Capel, Tom Groot Kormelink, Esther C. de Jong
Summary: This study investigated the effects of Vitamin D3 on the differentiation of specific human T cells. The results showed that Vitamin D3 can restrict the development of Th17 cells, promote the development of regulatory T cells, and reduce the production of specific cytokines by dendritic cells. This provides potential for the use of Vitamin D3 as an adjuvant in the treatment of autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Sayaka Ishihara, Tsuyoshi Sato, Noriyuki Fujikado, Haruka Miyazaki, Takayuki Yoshimoto, Hiromitsu Yamamoto, Shinji Fukuda, Koko Katagiri
Summary: T-cell-specific Rap1 deletion leads to spontaneous colitis in mice by impairing the induction of intestinal RORγt(+) Treg cells. In the absence of Rap1, Th17 cells increase in a microbiota-dependent manner, and blocking IL-17A production prevents colitis development. Rap1 deficiency in T cells impairs the development or maintenance of Rorγt(+) Tregs in the colonic lamina propria, resulting in an increase in pathogenic Th17 cells and spontaneous colitis.
COMMUNICATIONS BIOLOGY
(2022)
Review
Biology
Alexey V. Churov, Yegor S. Chegodaev, Victoria A. Khotina, Vladimir P. Ofitserov, Alexander N. Orekhov
Summary: Atherosclerosis is a vascular disease characterized by a long asymptomatic period and gradual development. The disease involves immune cell infiltration and inflammation in the vessel walls, but regulatory T cells help maintain immune balance and play a positive role in controlling the initiation and progression of atherosclerosis.
Article
Engineering, Biomedical
Lingting Shi, Jee Yoon Lim, Lance C. Kam
Summary: Regulatory T cells (Tregs) have the potential to suppress immune response and treat autoimmune diseases. This report investigates the induction of Tregs by modulating the mechanical stiffness of the activating substrate. It was found that Treg induction increased with greater material stiffness and involved oxidative phosphorylation (OXPHOS). Inhibition of ATP synthase reduced Treg induction, while activation of AMPK increased it on softer substrates. This mechanosensitive and OXPHOS-dependent mechanism provides new strategies for enhancing Treg production in cellular immunotherapy.
Review
Biochemistry & Molecular Biology
Michel Y. Braun
Summary: T cells, particularly T lymphocytes of the immune system, exhibit characteristics of proliferation and mobility in tissues and organs, requiring metabolic plasticity to fulfill their immune function. This review focuses on the various mechanisms that allow T cells to adapt their metabolism to different real-life circumstances, such as exiting quiescence, differentiating into effector cells, and participating in immune memory formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Rui Zhang, Jinlin Miao, Kui Zhang, Bei Zhang, Xing Luo, Haoyang Sun, Zhaohui Zheng, Ping Zhu
Summary: This study investigated the changes in quantity and function of Treg cell subsets in RA patients, finding that Th1-like Treg cells are the predominant subset in the synovial fluid of RA patients but with defective suppressive function.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Immunology
Tomoyoshi Yamano, Madlen Steinert, Beatrix Steer, Ludger Klein, Wolfgang Hammerschmidt, Heiko Adler
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Genetics & Heredity
Kayla Borland, Jan Diesend, Taku Ito-Kureha, Vigo Heissmeyer, Christian Hammann, Amy H. Buck, Stylianos Michalakis, Stefanie Kellner
Article
Immunology
Matthias von Gamm, Annalisa Schaub, Alisha N. Jones, Christine Wolf, Gesine Behrens, Johannes Lichti, Katharina Essig, Anna Macht, Joachim Pircher, Andreas Ehrlich, Kathrin Davari, Dhruv Chauhan, Benjamin Busch, Wolfgang Wurst, Regina Feederle, Annette Feuchtinger, Matthias H. Tschoep, Caroline C. Friedel, Stefanie M. Hauck, Michael Sattler, Arie Geerlof, Veit Hornung, Vigo Heissmeyer, Christian Schulz, Mathias Heikenwalder, Elke Glasmacher
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Multidisciplinary Sciences
S. J. Tavernier, V. Athanasopoulos, P. Verloo, G. Behrens, J. Staal, D. J. Bogaert, L. Naesens, M. De Bruyne, S. Van Gassen, E. Parthoens, J. Ellyard, J. Cappello, L. X. Morris, H. Van Gorp, G. Van Isterdael, Y. Saeys, M. Lamkanfi, P. Schelstraete, J. Dehoorne, V. Bordon, R. Van Coster, B. N. Lambrecht, B. Menten, R. Beyaert, C. G. Vinuesa, V. Heissmeyer, M. Dullaers, F. Haerynck
NATURE COMMUNICATIONS
(2019)
Correction
Multidisciplinary Sciences
S. J. Tavernier, V. Athanasopoulos, P. Verloo, G. Behrens, J. Staal, D. J. Bogaert, L. Naesens, M. De Bruyne, S. Van Gassen, E. Parthoens, J. Ellyard, J. Cappello, L. X. Morris, H. Van Gorp, G. Van Isterdael, Y. Saeys, M. Lamkanfi, P. Schelstraete, J. Dehoorne, V. Bordon, R. Van Coster, B. N. Lambrecht, B. Menten, R. Beyaert, C. G. Vinuesa, V. Heissmeyer, M. Dullaers, F. Haerynck
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Franziska Weichmann, Robert Hett, Aloys Schepers, Taku Ito-Kureha, Andrew Flatley, Kaouthar Slama, Florian D. Hastert, Nicholas B. Angstman, M. Cristina Cardoso, Julian Koenig, Stefan Huettelmaier, Christoph Dieterich, Stefan Canzar, Mark Helm, Vigo Heissmeyer, Regina Feederle, Gunter Meister
Article
Immunology
Ludger Klein
Article
Immunology
Mingyue Li, Weina Guo, Yalan Dong, Xiaobei Wang, Die Dai, Xingxing Liu, Yiquan Wu, Mengmeng Li, Wenjing Zhang, Haifeng Zhou, Zili Zhang, Lan Lin, Zhenyu Kang, Ting Yu, Chunxia Tian, Renjie Qin, Yang Gui, Feng Jiang, Heng Fan, Vigo Heissmeyer, Alexey Sarapultsev, Lin Wang, Shanshan Luo, Desheng Hu
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Kai P. Hoefig, Alexander Reim, Christian Gallus, Elaine H. Wong, Gesine Behrens, Christine Conrad, Meng Xu, Lisa Kifinger, Taku Ito-Kureha, Kyra A. Y. Defourny, Arie Geerlof, Josef Mautner, Stefanie M. Hauck, Dirk Baumjohann, Regina Feederle, Matthias Mann, Michael Wierer, Elke Glasmacher, Vigo Heissmeyer
Summary: Post-transcriptional gene regulation in T cells is a dynamic and complex process, involving multiple RNA-binding proteins and unexpected functions for certain transcription factors and signal transducers. By studying the regulation of Roquin-1 and Roquin-2, it was found that multiple RBPs contribute to the coregulation of mRNA targets by individual trans-acting factors.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Gesine Behrens, Stephanie L. Edelmann, Timsse Raj, Nina Kronbeck, Thomas Monecke, Elena Davydova, Elaine H. Wong, Lisa Kifinger, Florian Giesert, Martin E. Kirmaier, Christine Hohn, Laura S. de Jonge, Mariano Gonzalez Pisfil, Mingui Fu, Sebastian Theurich, Stefan Feske, Naoto Kawakami, Wolfgang Wurst, Dierk Niessing, Vigo Heissmeyer
Summary: The proteins Roquin-1 and Regnase-1 play crucial roles in maintaining immune homeostasis, with mutations leading to systemic lupus erythematosus-like phenotypes and autoimmunity. Additionally, these mutations affect T cell activation, metabolic reprogramming, and autoimmunity processes.
Review
Immunology
Gesine Behrens, Vigo Heissmeyer
Summary: Post-transcriptional gene regulation by RNA-binding proteins is crucial in preventing inflammatory and autoimmune diseases. RBPs Roquin-1/2 and Regnase-1 play significant roles in T cell activation and differentiation by degrading and silencing target mRNAs. Cooperation among trans-acting factors may reinforce the regulatory impact on selected targets and influence cell fate decisions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Thomas J. O'Neill, Thomas Seeholzer, Andreas Gewies, Torben Gehring, Florian Giesert, Isabel Hamp, Carina Grass, Henrik Schmidt, Katharina Kriegsmann, Marie J. Tofaute, Katrin Demski, Tanja Poth, Marc Rosenbaum, Theresa Schnalzger, Juergen Ruland, Martin Goettlicher, Mark Kriegsmann, Ronald Naumann, Vigo Heissmeyer, Oliver Plettenburg, Wolfgang Wurst, Daniel Krappmann
Summary: TRAF6 functions as a signaling accelerator for MALT1 scaffolding in activated T cells and as a molecular brake for MALT1 protease in resting T cells. Disruption of TRAF6-mediated homeostatic suppression of MALT1 protease leads to severe autoimmune inflammation, which can be completely reverted by genetic or therapeutic inactivation of MALT1 protease function.
SCIENCE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Gizem Guenes Guensel, Thomas M. Conlon, Aicha Jeridi, Rinho Kim, Zeynep Ertuez, Niklas J. Lang, Meshal Ansari, Mariia Novikova, Dongsheng Jiang, Maximilian Strunz, Mariia Gaianova, Christine Hollauer, Christina Gabriel, Ilias Angelidis, Sebastian Doll, Jeanine C. Pestoni, Stephanie L. Edelmann, Marlene Sophia Kohlhepp, Adrien Guillot, Kevin Bassler, Hannelore P. Van Eeckhoutte, Oezgecan Kayalar, Nur Konyalilar, Tamara Kanashova, Sophie Rodius, Carolina Ballester-Lopez, Carlos M. Genes Robles, Natalia Smirnova, Markus Rehberg, Charu Agarwal, Ioanna Krikki, Benoit Piavaux, Stijn E. Verleden, Bart Vanaudenaerde, Melanie Koenigshoff, Gunnar Dittmar, Ken R. Bracke, Joachim L. Schultze, Henrik Watz, Oliver Eickelberg, Tobias Stoeger, Gerald Burgstaller, Frank Tacke, Vigo Heissmeyer, Yuval Rinkevich, Hasan Bayram, Herbert B. Schiller, Marcus Conrad, Robert Schneider, Ali Oender Yildirim
Summary: This study demonstrates the role of PRMT7 in regulating the recruitment and pro-inflammatory phenotype of macrophages in chronic obstructive pulmonary disease (COPD). Reduced expression of PRMT7 is associated with decreased recruitment of monocytes to the site of injury and less severe symptoms in mouse models.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Ludger Klein, Ellen A. Robey, Chyi-Song Hsieh
NATURE REVIEWS IMMUNOLOGY
(2019)