Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities

Memantine Normalizes Several Phenotypic Features in the Ts65Dn Mouse Model of Down Syndrome

(2017) Noemí Rueda et al.   JOURNAL OF ALZHEIMERS DISEASE

Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation

(2011) Ira T. Lott et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Positron Emission Tomography and Neuropathologic Estimates of Fibrillar Amyloid-β in a Patient With Down Syndrome and Alzheimer Disease

(2011) Marwan N. Sabbagh   ARCHIVES OF NEUROLOGY

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

(2011) Giovanna Cenini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neurobiological Elements of Cognitive Dysfunction in Down Syndrome: Exploring the Role of APP

(2011) Martha Millan Sanchez et al.   BIOLOGICAL PSYCHIATRY

Environmental Enrichment Rescues Postnatal Neurogenesis Defect in the Male and Female Ts65Dn Mouse Model of Down Syndrome

(2011) Lina Chakrabarti et al.   DEVELOPMENTAL NEUROSCIENCE

Down syndrome: searching for the genetic culprits

(2011) E. Lana-Elola et al.   Disease Models & Mechanisms

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome

(2011) Stefania Trazzi et al.   HUMAN MOLECULAR GENETICS

The Ts65Dn mouse model of Down syndrome shows reduced expression of the Bcl-XL antiapoptotic protein in the hippocampus not accompanied by changes in molecular or cellular markers of cell death

(2011) Noemí Rueda et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Rescue of Synaptic Failure and Alleviation of Learning and Memory Impairments in a Trisomic Mouse Model of Down Syndrome

(2011) Julie Blanchard et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

(2011) J Braudeau et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine

(2011) J. J. Scott-McKean et al.   LEARNING & MEMORY

Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

(2011) Xiaolu Sturgeon et al.   MAMMALIAN GENOME

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

(2011) Arnaud Duchon et al.   MAMMALIAN GENOME

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

(2011) Alexander M. Kleschevnikov et al.   NEUROBIOLOGY OF DISEASE

Prevention of Learning Deficit in a Down Syndrome Model

(2011) Maddalena Incerti et al.   OBSTETRICS AND GYNECOLOGY

Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17

(2010) Priya S. Kishnani et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

(2010) Jason Lockrow et al.   BEHAVIOURAL BRAIN RESEARCH

Widespread Proliferation Impairment and Hypocellularity in the Cerebellum of Fetuses with Down Syndrome

(2010) Sandra Guidi et al.   BRAIN PATHOLOGY

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice

(2010) Tao Yu et al.   BRAIN RESEARCH

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

(2010) Tao Yu et al.   HUMAN MOLECULAR GENETICS

Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells

(2010) Joongkyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of down syndrome

(2010) Victor I. Popov et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down’s syndrome

(2010) D. Pérez-Cremades et al.   JOURNAL OF NEURAL TRANSMISSION

Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells

(2010) O. Yabut et al.   JOURNAL OF NEUROSCIENCE

Early Pharmacotherapy Restores Neurogenesis and Cognitive Performance in the Ts65Dn Mouse Model for Down Syndrome

(2010) P. Bianchi et al.   JOURNAL OF NEUROSCIENCE

Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin

(2010) Yu Fukuda et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

(2010) Lina Chakrabarti et al.   NATURE NEUROSCIENCE

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations

(2010) Debra Toiber et al.   NEUROBIOLOGY OF DISEASE

Behavioral flexibility in a mouse model of developmental cerebellar Purkinje cell loss

(2010) Price E. Dickson et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome

(2010) M.V. Llorens-Martín et al.   NEUROSCIENCE

Prevention of Developmental Delays in a Down Syndrome Mouse Model

(2010) Laura Toso et al.   OBSTETRICS AND GYNECOLOGY

Effect of Leucovorin (Folinic Acid) on the Developmental Quotient of Children with Down's Syndrome (Trisomy 21) and Influence of Thyroid Status

(2010) Henri Blehaut et al.   PLoS One

Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model

(2010) William J. Netzer et al.   PLoS One

Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome

(2010) Chelsee A. Hewitt et al.   PLoS One

The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome

(2009) Priya S. Kishnani et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development

(2009) Julien Laffaire et al.   BMC GENOMICS

Lithium Restores Neurogenesis in the Subventricular Zone of the Ts65Dn Mouse, a Model for Down Syndrome

(2009) Patrizia Bianchi et al.   BRAIN PATHOLOGY

Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome

(2009) A. Contestabile et al.   CELL PROLIFERATION

Enlarged Brain Ventricles and Impaired Neurogenesis in the Ts1Cje and Ts2Cje Mouse Models of Down Syndrome

(2009) Keiichi Ishihara et al.   CEREBRAL CORTEX

A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells

(2009) Anita Bhattacharyya et al.   DEVELOPMENTAL NEUROSCIENCE

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome

(2009) M. Galante et al.   HUMAN MOLECULAR GENETICS

A new mouse model for the trisomy of the Abcg1–U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

(2009) Patricia Lopes Pereira et al.   HUMAN MOLECULAR GENETICS

Widespread changes in dendritic and axonal morphology inMecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

(2009) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome

(2009) Fabian Fernandez et al.   JOURNAL OF NEUROCHEMISTRY

Increased lipid peroxidation in Down’s syndrome mouse models

(2009) Keiichi Ishihara et al.   JOURNAL OF NEUROCHEMISTRY

The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

(2009) N. P. Belichenko et al.   JOURNAL OF NEUROSCIENCE

Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres

(2009) Randal X. Moldrich et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The complex relationship between folate/homocysteine metabolism and risk of Down syndrome

(2009) Fabio Coppedè   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide

(2009) Muhammad Omar Chohan et al.   NEUROBIOLOGY OF AGING

Prevalence of Down Syndrome Among Children and Adolescents in 10 Regions of the United States

(2009) M. Shin et al.   PEDIATRICS

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of Norepinephrine-Modulated Contextual Memory in a Mouse Model of Down Syndrome

(2009) A. Salehi et al.   Science Translational Medicine

Spine microdomains for postsynaptic signaling and plasticity

(2009) Thomas M. Newpher et al.   TRENDS IN CELL BIOLOGY

Targeting Dyrk1A with AAVshRNA Attenuates Motor Alterations in TgDyrk1A, a Mouse Model of Down Syndrome

(2008) Jon Ortiz-Abalia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Reduced cell number in the neocortical part of the human fetal brain in Down syndrome

(2008) Karen Bonde Larsen et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Minocycline and neurodegenerative diseases

(2008) Hye-Sun Kim et al.   BEHAVIOURAL BRAIN RESEARCH

The potential of hematopoietic growth factors for treatment of Alzheimer's disease: a mini-review

(2008) Juan Sanchez-Ramos et al.   BMC NEUROSCIENCE

Cell Cycle Elongation Impairs Proliferation of Cerebellar Granule Cell Precursors in the Ts65Dn Mouse, an Animal Model for Down Syndrome

(2008) Andrea Contestabile et al.   BRAIN PATHOLOGY

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model

(2008) Jason Lockrow et al.   EXPERIMENTAL NEUROLOGY

Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801

(2008) A. Siddiqui et al.   GENES BRAIN AND BEHAVIOR

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of down syndrome

(2008) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Chronic Fluoxetine Stimulates Maturation and Synaptic Plasticity of Adult-Born Hippocampal Granule Cells

(2008) J.-W. Wang et al.   JOURNAL OF NEUROSCIENCE

Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

(2008) E. Morice et al.   LEARNING & MEMORY

Neurogenesis and Exercise: Past and Future Directions

(2008) Henriette van Praag   NEUROMOLECULAR MEDICINE

Abnormal expression of synaptic proteins and neurotrophin-3 in the down syndrome mouse model Ts65Dn

(2008) G. Pollonini et al.   NEUROSCIENCE

Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice

(2008) P.J. Clark et al.   NEUROSCIENCE

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

(2008) N. Rueda et al.   NEUROSCIENCE LETTERS

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

(2008) Theresa M. Ballard et al.   PSYCHOPHARMACOLOGY

Supplementation with antioxidants and folinic acid for children with Down’s syndrome: randomised controlled trial

(2008) Jill M Ellis et al.   BMJ-British Medical Journal

Episodic-like memory in Ts65Dn, a mouse model of Down syndrome

(2007) Fabian Fernandez et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome

(2007) N RUEDA   BEHAVIOURAL BRAIN RESEARCH