☆ 4.7 Article

New Perspectives for the Rescue of Cognitive Disability in Down Syndrome

JOURNAL OF NEUROSCIENCE (2015)

期刊

JOURNAL OF NEUROSCIENCE

卷 35, 期 41, 页码 13843-13852

出版社

SOC NEUROSCIENCE

DOI: 10.1523/JNEUROSCI.2775-15.2015

关键词

Down syndrome; intellectual disability; brain abnormalities; mouse models; preventive therapies

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Neurosciences

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摘要

Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.

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