STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation

Oncogenetic landscape of lymphomagenesis in coeliac disease

(2021) Sascha Cording et al.   GUT

A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance

(2021) Jeremy T. Warshauer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Somatic STAT3 mutations in CD8+ T cells of healthy blood donors carrying human T-cell leukemia virus type 2

(2021) Daehong Kim et al.   HAEMATOLOGICA

CD8+ cell somatic mutations in multiple sclerosis patients and controls—Enrichment of mutations in STAT3 and other genes implicated in hematological malignancies

(2021) Miko Valori et al.   PLoS One

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

(2020) Susanna S. Ng et al.   NATURE IMMUNOLOGY

Clinical aspects of STAT3 gain-of-function germline mutations: A Systematic Review

(2019) Alexandre Fabre et al.   Journal of Allergy and Clinical Immunology-In Practice

High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes

(2019) Mandeep Singh et al.   Nature Communications

Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

(2019) Chunwan Lu et al.   Journal for ImmunoTherapy of Cancer

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

(2019) Elvin D. de Araujo et al.   Cancers

Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer

(2019) Thomas A. Waldmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT3 mutation and its clinical and histopathologic correlation in T-cell large granular lymphocytic leukemia

(2018) Min Shi et al.   HUMAN PATHOLOGY

Interleukin-10 Directly Inhibits CD8 + T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity

(2018) Logan K. Smith et al.   IMMUNITY

Innate-like Cytotoxic Function of Bystander-Activated CD8 + T Cells Is Associated with Liver Injury in Acute Hepatitis A

(2018) Jihye Kim et al.   IMMUNITY

SAVER: gene expression recovery for single-cell RNA sequencing

(2018) Mo Huang et al.   NATURE METHODS

Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

(2018) Elissa K. Deenick et al.   Frontiers in Immunology

Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia

(2017) Paula Savola et al.   HAEMATOLOGICA

Simultaneous epitope and transcriptome measurement in single cells

(2017) Marlon Stoeckius et al.   NATURE METHODS

Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia

(2017) Paula Savola et al.   HAEMATOLOGICA

STAT3 mutations are not sufficient to induce large granular lymphocytic leukaemia in mice

(2016) Avik Dutta et al.   BRITISH JOURNAL OF HAEMATOLOGY

Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease

(2016) Julien Ettersperger et al.   IMMUNITY

Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia

(2015) E Andersson et al.   LEUKEMIA

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires

(2014) Jason A. Vander Heiden et al.   BIOINFORMATICS

Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation

(2014) S. Zhu et al.   BLOOD

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3

(2014) E. M. Haapaniemi et al.   BLOOD

Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations

(2014) J. D. Milner et al.   BLOOD

The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia

(2014) H. L. M. Rajala et al.   HAEMATOLOGICA

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

(2014) Sarah E Flanagan et al.   NATURE GENETICS

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

(2014) Luzhou Xing et al.   NATURE MEDICINE

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering

(2014) Hui Yang et al.   Nature Protocols

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Regulation of Ligands for the NKG2D Activating Receptor

(2013) David H. Raulet et al.   Annual Review of Immunology

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

(2013) A. Jerez et al.   BLOOD

STAT3gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia

(2013) Fumihiro Ishida et al.   CANCER SCIENCE

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model

(2013) L. Couronne et al.   HAEMATOLOGICA

Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8+ T-cell memory formation and function

(2013) Megan L. Ives et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Characterization and Favorablein VivoProperties of Heterodimeric Soluble IL-15·IL-15Rα Cytokine Compared to IL-15 Monomer

(2013) Elena Chertova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia

(2013) Zhi-Yuan Qiu et al.   Journal of Hematology & Oncology

JAKs and STATs in Immunity, Immunodeficiency, and Cancer

(2013) John J. O'Shea et al.   NEW ENGLAND JOURNAL OF MEDICINE

IgBLAST: an immunoglobulin variable domain sequence analysis tool

(2013) Jian Ye et al.   NUCLEIC ACIDS RESEARCH

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia

(2012) A. Jerez et al.   BLOOD

RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition

(2012) Mary A. Markiewicz et al.   IMMUNITY

STAT3 mutations are highly specific for large granular lymphocytic leukemia

(2012) A Fasan et al.   LEUKEMIA

SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia

(2012) Hanna L.M. Koskela et al.   NEW ENGLAND JOURNAL OF MEDICINE

FLASH: fast length adjustment of short reads to improve genome assemblies

(2011) T. Magoc et al.   BIOINFORMATICS

Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the  c cytokines and TGF- 1

(2011) Y. P. Park et al.   BLOOD

Increased serum soluble IL-15R  levels in T-cell large granular lymphocyte leukemia

(2011) J. Chen et al.   BLOOD

A Critical Role for STAT3 Transcription Factor Signaling in the Development and Maintenance of Human T Cell Memory

(2011) Andrea M. Siegel et al.   IMMUNITY

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells

(2011) Weiguo Cui et al.   IMMUNITY

CD57+ T lymphocytes and functional immune deficiency

(2009) Daniele Focosi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation

(2008) S. W. Stonier et al.   BLOOD

T cell subset-specific susceptibility to aging

(2008) Marta Czesnikiewicz-Guzik et al.   CLINICAL IMMUNOLOGY