Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer
出版年份 2019 全文链接
标题
Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer
作者
关键词
-
出版物
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 217, Issue 1, Pages -
出版商
Rockefeller University Press
发表日期
2019-12-10
DOI
10.1084/jem.20191062
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report
- (2019) Lucy B. Cook et al. JOURNAL OF CLINICAL ONCOLOGY
- Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy
- (2019) Karin M. Knudson et al. Journal for ImmunoTherapy of Cancer
- Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model
- (2019) Hideki Furuya et al. Journal of Translational Medicine
- Development of a recombinant human IL-15·sIL-15Rα/Fc superagonist with improved half-life and its antitumor activity alone or in combination with PD-1 blockade in mouse model
- (2019) Meiqi Zhao et al. BIOMEDICINE & PHARMACOTHERAPY
- IL-15 by continuous i.v. infusion to adult patients with solid tumors in a Phase I trial induced dramatic NK cell subset expansion
- (2019) Kevin C Conlon et al. CLINICAL CANCER RESEARCH
- A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients
- (2019) Joseph Cursons et al. Cancer Immunology Research
- First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation
- (2018) Rizwan Romee et al. BLOOD
- Optimized administration of hetIL-15 expands lymphocytes and minimizes toxicity in rhesus macaques
- (2018) Cristina Bergamaschi et al. CYTOKINE
- Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells
- (2018) Kristina S. Burrack et al. IMMUNITY
- Current strategies exploiting NK-cell therapy to treat haematologic malignancies
- (2018) Jenna K. Johnson et al. International Journal of Immunogenetics
- ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial
- (2018) John M Wrangle et al. LANCET ONCOLOGY
- Superagonist IL-15-armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade
- (2018) Stacy J. Kowalsky et al. MOLECULAR THERAPY
- Human intraepithelial lymphocytes
- (2018) Toufic Mayassi et al. Mucosal Immunology
- Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo
- (2018) Jillian M. Richmond et al. Science Translational Medicine
- Beneficial Effects of Human Anti-Interleukin-15 Antibody in Gluten-Sensitive Rhesus Macaques with Celiac Disease
- (2018) Karol Sestak et al. Frontiers in Immunology
- IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability
- (2018) T. Tiffany Wang et al. LEUKEMIA
- IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages
- (2018) Meili Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antibody-dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells
- (2017) Maria Carmen Ochoa et al. IMMUNOLOGY AND CELL BIOLOGY
- The potential and promise of IL-15 in immuno-oncogenic therapies
- (2017) Tanya O. Robinson et al. IMMUNOLOGY LETTERS
- The Common Cytokine Receptor γ Chain Family of Cytokines
- (2017) Jian-Xin Lin et al. Cold Spring Harbor Perspectives in Biology
- Cytokines in Cancer Immunotherapy
- (2017) Thomas A. Waldmann Cold Spring Harbor Perspectives in Biology
- IL-15 sustains IL-7R-independent ILC2 and ILC3 development
- (2017) Michelle L. Robinette et al. Nature Communications
- IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56 bright NK Cells and Increases NK-Cell Cytokine Release Capabilities
- (2017) Sigrid Dubois et al. Cancer Immunology Research
- Enhancement of antibody-dependent cellular cytotoxicity of cetuximab by a chimeric protein encompassing interleukin-15
- (2017) Maria Carmen Ochoa et al. OncoImmunology
- Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement
- (2016) Rony Dahan et al. CANCER CELL
- Interleukin 15: A key cytokine for immunotherapy
- (2016) Manoj Patidar et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease
- (2016) Julien Ettersperger et al. IMMUNITY
- A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody Demonstrates Antigen-specific Antitumor Responses
- (2016) Bai Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-15Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8+T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists
- (2016) Mélanie Desbois et al. JOURNAL OF IMMUNOLOGY
- Enhanced ADCC and NK Cell Activation of an Anticarcinoma Bispecific Antibody by Genetic Insertion of a Modified IL-15 Cross-linker
- (2016) Joerg U Schmohl et al. MOLECULAR THERAPY
- CIS is a potent checkpoint in NK cell–mediated tumor immunity
- (2016) Rebecca B Delconte et al. NATURE IMMUNOLOGY
- Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia
- (2016) Rizwan Romee et al. Science Translational Medicine
- Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma
- (2016) A. Mishra et al. Cancer Discovery
- An activation-induced IL-15 isoform is a natural antagonist for IL-15 function
- (2016) Lei Zhao et al. Scientific Reports
- CIS is a negative regulator of IL-15-mediated signals in NK cells
- (2016) Cristina Bottino et al. Translational Cancer Research
- IL15 and T-cell Stemness in T-cell-Based Cancer Immunotherapy
- (2015) K. Pilipow et al. CANCER RESEARCH
- Interleukin-15, a Master Piece in the Immunological Jigsaw of Celiac Disease
- (2015) Bertrand Meresse et al. DIGESTIVE DISEASES
- Out-of-Sequence Signal 3 Paralyzes Primary CD4+ T-Cell-Dependent Immunity
- (2015) Gail D. Sckisel et al. IMMUNITY
- Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps
- (2015) Suman Mitra et al. IMMUNITY
- Targeting the Binding Interface on a Shared Receptor Subunit of a Cytokine Family Enables the Inhibition of Multiple Member Cytokines with Selectable Target Spectrum
- (2015) Toshie Nata et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer
- (2015) Kevin C. Conlon et al. JOURNAL OF CLINICAL ONCOLOGY
- Human Cytokine-Induced Memory-Like Natural Killer Cells
- (2015) Melissa M. Berrien-Elliott et al. Journal of Innate Immunity
- Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2–dependent adult T-cell leukemia
- (2015) Meili Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Shared and Contrasting Roles of IL2 and IL15 in the Life and Death of Normal and Neoplastic Lymphocytes: Implications for Cancer Therapy
- (2015) T. A. Waldmann Cancer Immunology Research
- Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer
- (2014) A. Mishra et al. CLINICAL CANCER RESEARCH
- Interleukin-15 in the treatment of cancer
- (2014) Thomas A Waldmann Expert Review of Clinical Immunology
- T-bet Orchestrates CD8αα IEL Differentiation
- (2014) Brandon Kwong et al. IMMUNITY
- The Transcription Factor T-bet Is Induced by IL-15 and Thymic Agonist Selection and Controls CD8αα+ Intraepithelial Lymphocyte Development
- (2014) Christoph S.N. Klose et al. IMMUNITY
- IL-15: a central regulator of celiac disease immunopathology
- (2014) Valérie Abadie et al. IMMUNOLOGICAL REVIEWS
- The unconventional expression of IL-15 and its role in NK cell homeostasis
- (2014) Nicholas D Huntington IMMUNOLOGY AND CELL BIOLOGY
- Preassociation of IL-15 with IL-15R -IgG1-Fc Enhances Its Activity on Proliferation of NK and CD8+/CD44high T Cells and Its Antitumor Action
- (2014) S. Dubois et al. JOURNAL OF IMMUNOLOGY
- IL-2: The First Effective Immunotherapy for Human Cancer
- (2014) S. A. Rosenberg JOURNAL OF IMMUNOLOGY
- Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse
- (2014) Marie Vincent et al. mAbs
- Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition
- (2014) Luzhou Xing et al. NATURE MEDICINE
- Interleukin 15 and CD4+ T Cells Cooperate to Promote Small Intestinal Enteropathy in Response to Dietary Antigen
- (2013) Natalia Korneychuk et al. GASTROENTEROLOGY
- Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells
- (2013) Anja Fuchs et al. IMMUNITY
- Characterization and Favorablein VivoProperties of Heterodimeric Soluble IL-15·IL-15Rα Cytokine Compared to IL-15 Monomer
- (2013) Elena Chertova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epidermal IL-15Rα acts as an endogenous antagonist of psoriasiform inflammation in mouse and man
- (2013) Grégory Bouchaud et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
- (2013) Laura K Mackay et al. NATURE IMMUNOLOGY
- Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15R
- (2013) J. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-15 cis Presentation Is Required for Optimal NK Cell Activation in Lipopolysaccharide-Mediated Inflammatory Conditions
- (2013) Ivan Zanoni et al. Cell Reports
- Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia
- (2012) T. A. Waldmann et al. BLOOD
- Circulating IL-15 exists as heterodimeric complex with soluble IL-15R in human and mouse serum
- (2012) C. Bergamaschi et al. BLOOD
- Cytokine activation induces human memory-like NK cells
- (2012) R. Romee et al. BLOOD
- IL-2- or IL-15-activated NK cells enhance Cetuximab-mediated activity against triple-negative breast cancer in xenografts and in breast cancer patients
- (2012) María P. Roberti et al. BREAST CANCER RESEARCH AND TREATMENT
- Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation
- (2012) Anjali Mishra et al. CANCER CELL
- Regulating the immune system via IL-15 transpresentation
- (2012) Eliseo F. Castillo et al. CYTOKINE
- Augmented IL-15R Expression by CD40 Activation Is Critical in Synergistic CD8 T Cell-Mediated Antitumor Activity of Anti-CD40 Antibody with IL-15 in TRAMP-C2 Tumors in Mice
- (2012) M. Zhang et al. JOURNAL OF IMMUNOLOGY
- Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
- (2012) P. Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of IL-15 in central nervous system disorders
- (2011) M. Rentzos et al. ACTA NEUROLOGICA SCANDINAVICA
- Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques
- (2011) T. A. Waldmann et al. BLOOD
- Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R
- (2011) N. Sato et al. BLOOD
- Increased serum soluble IL-15R levels in T-cell large granular lymphocyte leukemia
- (2011) J. Chen et al. BLOOD
- IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood
- (2011) M. C. Sneller et al. BLOOD
- Interleukin 15 as a promising candidate for tumor immunotherapy
- (2011) Marek Jakobisiak et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Interleukin-15 enhances rituximab-dependent cytotoxicity against chronic lymphocytic leukemia cells and overcomes transforming growth factor beta-mediated immunosuppression
- (2011) Esther Moga et al. EXPERIMENTAL HEMATOLOGY
- Inhibitory Fc Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies
- (2011) F. Li et al. SCIENCE
- Interleukin-15 biology and its therapeutic implications in cancer
- (2011) Jason C. Steel et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP
- (2010) W. Ju et al. BLOOD
- Simultaneous Blockade of Multiple Immune System Inhibitory Checkpoints Enhances Antitumor Activity Mediated by Interleukin-15 in a Murine Metastatic Colon Carcinoma Model
- (2010) P. Yu et al. CLINICAL CANCER RESEARCH
- The power and the promise of restimulation-induced cell death in human immune diseases
- (2010) Andrew L. Snow et al. IMMUNOLOGICAL REVIEWS
- Suppressor of Cytokine Signaling 2 Regulates IL-15-Primed Human NK Cell Function via Control of Phosphorylated Pyk2
- (2010) S. H. Lee et al. JOURNAL OF IMMUNOLOGY
- Functions of γC cytokines in immune homeostasis: Current and potential clinical applications
- (2009) Willem W. Overwijk et al. CLINICAL IMMUNOLOGY
- Homeostatic proliferation and survival of naïve and memory T cells
- (2009) Onur Boyman et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- A Dual Action of Rheumatoid Arthritis Synovial Fibroblast IL-15 Expression on the Equilibrium between CD4+CD25+ Regulatory T Cells and CD4+CD25- Responder T Cells
- (2009) M. Benito-Miguel et al. JOURNAL OF IMMUNOLOGY
- Novel Human Interleukin-15 Agonists
- (2009) X. Zhu et al. JOURNAL OF IMMUNOLOGY
- SOCS1 Links Cytokine Signaling to p53 and Senescence
- (2009) Viviane Calabrese et al. MOLECULAR CELL
- Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer
- (2009) M. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes
- (2009) S. Yokoyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism
- (2008) J. Chen et al. BLOOD
- CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I–αβTCR interaction and become IL-10-producing active regulatory cells
- (2008) Muhaimin Rifa'i et al. INTERNATIONAL IMMUNOLOGY
- IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
- (2008) Nicholas D. Huntington et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Membrane bound IL-15 is increased on CD14 monocytes in early stages of MS
- (2008) Adi Vaknin-Dembinsky et al. JOURNAL OF NEUROIMMUNOLOGY
- Network model of survival signaling in large granular lymphocyte leukemia
- (2008) R. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started