Characterization and Favorablein VivoProperties of Heterodimeric Soluble IL-15·IL-15Rα Cytokine Compared to IL-15 Monomer

Preassociation of IL-15 with IL-15R -IgG1-Fc Enhances Its Activity on Proliferation of NK and CD8+/CD44high T Cells and Its Antitumor Action

(2014) S. Dubois et al.   JOURNAL OF IMMUNOLOGY

Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation

(2012) M.-A. Perales et al.   BLOOD

Circulating IL-15 exists as heterodimeric complex with soluble IL-15R  in human and mouse serum

(2012) C. Bergamaschi et al.   BLOOD

Immunotherapeutic applications of IL-15

(2012) Michela Croce et al.   Immunotherapy

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

Clinical manufacturing of recombinant human interleukin 15. I. Production cell line development and protein expression in E. coli with stop codon optimization

(2011) Vinay V. Vyas et al.   BIOTECHNOLOGY PROGRESS

Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques

(2011) T. A. Waldmann et al.   BLOOD

IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood

(2011) M. C. Sneller et al.   BLOOD

IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization

(2011) Kai-ping Han et al.   CYTOKINE

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

(2011) R. W. DePaolo et al.   NATURE

Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates

(2010) E. Lugli et al.   BLOOD

Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques

(2009) S. Beq et al.   BLOOD

Safety and immunologic effects of IL-15 administration in nonhuman primates

(2009) C. Berger et al.   BLOOD

Secretion and Biological Activity of Short Signal Peptide IL-15 Is Chaperoned by IL-15 Receptor Alpha In Vivo

(2009) C. Bergamaschi et al.   JOURNAL OF IMMUNOLOGY

Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer

(2009) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Biophysical Studies of the Human IL-7/IL-7Rα Complex

(2009) Craig A. McElroy et al.   STRUCTURE

Interleukin-15/Interleukin-15R  Complexes Promote Destruction of Established Tumors by Reviving Tumor-Resident CD8+ T Cells

(2008) M. Epardaud et al.   CANCER RESEARCH

Twelve immunotherapy drugs that could cure cancers

(2008) Martin A. ‘Mac’ Cheever   IMMUNOLOGICAL REVIEWS

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

(2008) Mark E. Dudley et al.   JOURNAL OF CLINICAL ONCOLOGY

IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation

(2008) Erwan Mortier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of glycosylation on the stability of protein pharmaceuticals

(2008) Ricardo J. Solá et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

How a Cytokine Is Chaperoned through the Secretory Pathway by Complexing with Its Own Receptor: Lessons from Interleukin-15 (IL-15)/IL-15 Receptor  

(2008) E. H. Duitman et al.   MOLECULAR AND CELLULAR BIOLOGY