A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance

ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis

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Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals

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Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype

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Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

(2020) Jean-Christophe Beltra et al.   IMMUNITY

Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes

(2020) Pavel N. Zakharov et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

(2020) Hossam A. Abdelsamed et al.   NATURE IMMUNOLOGY

Type 1 Diabetes in STAT Protein Family Mutations: Regulating the Th17/Treg Equilibrium and Beyond

(2019) Marco Fabbri et al.   DIABETES

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

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Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

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Comprehensive Integration of Single-Cell Data

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An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

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Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

(2019) Ansuman T. Satpathy et al.   NATURE BIOTECHNOLOGY

New Frontiers in the Treatment of Type 1 Diabetes

(2019) Jeremy T. Warshauer et al.   Cell Metabolism

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

(2019) William H. Hudson et al.   IMMUNITY

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

(2019) Alice E. Wiedeman et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort

(2018) Ashok Sharma et al.   JOURNAL OF AUTOIMMUNITY

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

(2018) Lorraine Yeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes

(2018) Emmi-Leena Ihantola et al.   JOURNAL OF IMMUNOLOGY

Short Stature in a Boy with Multiple Early-Onset Autoimmune Conditions due to a STAT3 Activating Mutation: Could Intracellular Growth Hormone Signalling Be Compromised?


(2017) Hana Sediva et al.   Hormone Research in Paediatrics

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

(2017) J. Justin Milner et al.   NATURE

Is autoimmunity the Achilles' heel of cancer immunotherapy?

(2017) Carl H June et al.   NATURE MEDICINE

chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data

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A STAT3-dependent transcriptional circuitry inhibits cytotoxic gene expression in T cells

(2017) Thomas Ciucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

(2017) Jonna Saarimäki-Vire et al.   Cell Reports

Circulating CXCR5 + PD-1 + ICOS + Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies

(2016) Tyyne Viisanen et al.   DIABETES

Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes

(2016) Jane H. Buckner et al.   JOURNAL OF AUTOIMMUNITY

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression

(2016) Christian Hundhausen et al.   Science Translational Medicine

Genetic Diagnosis Using Whole Exome Sequencing in Common Variable Immunodeficiency

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A Continuous Molecular Roadmap to iPSC Reprogramming through Progression Analysis of Single-Cell Mass Cytometry

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T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

A novel human STAT3 mutation presents with autoimmunity involving Th17 hyperactivation

(2015) Judith Wienke et al.   Oncotarget

Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations

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Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

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Common Variants on Cytotoxic T Lymphocyte Antigen-4 Polymorphisms Contributes to Type 1 Diabetes Susceptibility: Evidence Based on 58 Studies

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Normalization of mass cytometry data with bead standards

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Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

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JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

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An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells

(2011) Weiguo Cui et al.   IMMUNITY

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes

(2010) A. K. Marwaha et al.   JOURNAL OF IMMUNOLOGY

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

KLF2 Transcription-Factor Deficiency in T Cells Results in Unrestrained Cytokine Production and Upregulation of Bystander Chemokine Receptors

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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

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HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families

(2008) H. Erlich et al.   DIABETES

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

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