Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia

(2019) Sebastian Kollmann et al.   LEUKEMIA

Association between STAT3 mutations and phenotypic features in Hyper-IgE Syndrome

(2019) Marcos R. Goncalves et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural and functional consequences of the STAT5BN642H driver mutation

(2019) Elvin D. de Araujo et al.   Nature Communications

Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2

(2018) Constance Baer et al.   HAEMATOLOGICA

STAT3 mutation and its clinical and histopathologic correlation in T-cell large granular lymphocytic leukemia

(2018) Min Shi et al.   HUMAN PATHOLOGY

Pharmacologic inhibition of STAT5 in acute myeloid leukemia

(2018) Bettina Wingelhofer et al.   LEUKEMIA

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

(2018) Bettina Wingelhofer et al.   LEUKEMIA

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

(2018) Olli Dufva et al.   Nature Communications

Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation

(2018) Jürgen Klammt et al.   Nature Communications

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

(2018) A. Schrader et al.   Nature Communications

Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2

(2018) Constance Baer et al.   HAEMATOLOGICA

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

(2018) Tammy Linlin Song et al.   BLOOD

DNA methylation profiling identifies candidate genes for the pathogenesis of hepatosplenic T-cell lymphoma

(2018) Anke K. Bergmann et al.   HAEMATOLOGICA

A functional in vitro assay for screening inhibitors of STAT5B phosphorylation

(2018) Elvin D. de Araujo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia

(2018) Nicholas C. P. Cross et al.   LEUKEMIA

Novel Mutation in SH2 Domain of STAT3 (p.M660T) in Hyper-IgE Syndrome with Sterno-Clavicular and Paravertebral Abscesses

(2017) Biman Saikia et al.   INDIAN JOURNAL OF PEDIATRICS

STAT5BN642H is a driver mutation for T cell neoplasia

(2017) Ha Thi Thanh Pham et al.   JOURNAL OF CLINICAL INVESTIGATION

High-throughput thermofluor-based assays for inhibitor screening of STAT SH2 domains

(2017) Elvin D. de Araujo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

(2017) E I Andersson et al.   LEUKEMIA

The Genetic Basis of Hepatosplenic T-cell Lymphoma

(2017) Matthew McKinney et al.   Cancer Discovery

STAT3 mutation impacts biological and clinical features of T-LGL leukemia

(2017) Antonella Teramo et al.   Oncotarget

Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b

(2017) Nagarajan Elumalai et al.   Scientific Reports

Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome

(2016) C. E. Bocchini et al.   BLOOD

Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea

(2016) Chi A. Ma et al.   BLOOD

Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia

(2016) M. Bellon et al.   BLOOD

High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia

(2016) E. I. Andersson et al.   BLOOD

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors

(2016) V.-P. Lavallee et al.   BLOOD

CSF3R T618I, ASXL1 G942 fs and STAT5B N642H trimutation co-contribute to a rare chronic neutrophilic leukaemia manifested by rapidly progressive leucocytosis, severe infections, persistent fever and deep venous thrombosis

(2016) Qianhui Luo et al.   BRITISH JOURNAL OF HAEMATOLOGY

Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia

(2016) Cristina López et al.   BRITISH JOURNAL OF HAEMATOLOGY

Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities

(2016) Ahmed M. Ali et al.   ChemMedChem

STAT5B deficiency: Impacts on human growth and immunity

(2016) Vivian Hwa   GROWTH HORMONE & IGF RESEARCH

Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

(2016) P. Blombery et al.   HAEMATOLOGICA

Distinct mutations at the same positions of STAT3 cause either loss or gain of function

(2016) Prabha Chandrasekaran et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of Gene Mutations and Fusion Genes in Patients with Sézary Syndrome

(2016) Aparna Prasad et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma

(2016) M-L Nairismägi et al.   LEUKEMIA

Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations

(2016) Annalisa Roberti et al.   Nature Communications

Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

(2016) P. Blombery et al.   HAEMATOLOGICA

Primary CNS T-cell Lymphomas

(2015) Madhu P. Menon et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

STAT3: too much may be worse than not enough!

(2015) E. Haddad   BLOOD

Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma

(2015) Ramona Crescenzo et al.   CANCER CELL

Endemic mycoses in patients with STAT3-mutated hyper-IgE (Job) syndrome

(2015) Camila D. Odio et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An SH2 domain model of STAT5 in complex with phospho-peptides define “STAT5 Binding Signatures”

(2015) Eleonora Gianti et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Inflammatory hepatocellular adenomas developed in the setting of chronic liver disease and cirrhosis

(2015) Julien Calderaro et al.   MODERN PATHOLOGY

Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)

(2015) Lara Brambilla et al.   Molecular Oncology

Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma

(2015) Lu Jiang et al.   NATURE GENETICS

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome

(2015) Mark J. Kiel et al.   Nature Communications

Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells

(2015) Can Küçük et al.   Nature Communications

Rare occurrence of a STAT5B N642H mutation in adult T-cell acute lymphoblastic leukemia

(2015) Xiaolin Ma et al.   Cancer Genetics

Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

(2015) Daria V. Babushok et al.   Cancer Genetics

How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5

(2015) Florent Langenfeld et al.   PLoS One

Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma

(2015) Haley M. Simpson et al.   PLoS One

STAT5b in LGL leukemia – a novel therapeutic target?

(2015) Hanna L. M. Rajala et al.   Oncotarget

Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia

(2014) M. J. Kiel et al.   BLOOD

Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations

(2014) J. D. Milner et al.   BLOOD

STAT3 mutations are present in aggressive B-cell lymphomas including a subset of diffuse large B-cell lymphomas with CD30 expression

(2014) R. S. Ohgami et al.   HAEMATOLOGICA

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

(2014) O. R. Bandapalli et al.   HAEMATOLOGICA

A Negative Feedback Loop Mediated by STAT3 Limits Human Th17 Responses

(2014) H. A. Purvis et al.   JOURNAL OF IMMUNOLOGY

Clinical Relevance of Sensitive and Quantitative STAT3 Mutation Analysis Using Next-Generation Sequencing in T-Cell Large Granular Lymphocytic Leukemia

(2014) Thomas Kristensen et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas

(2014) A Nicolae et al.   LEUKEMIA

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

(2014) M Kontro et al.   LEUKEMIA

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

(2014) Sarah E Flanagan et al.   NATURE GENETICS

STAT3exon 21 mutation is rare in common human cancers

(2013) Min Sung Kim et al.   ACTA ONCOLOGICA

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

(2013) H. L. M. Rajala et al.   BLOOD

STAT3gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia

(2013) Fumihiro Ishida et al.   CANCER SCIENCE

Observation of unphosphorylated STAT3 core protein binding to targetdsDNA by PEMSA and X-ray crystallography

(2013) Edwin Nkansah et al.   FEBS LETTERS

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model

(2013) L. Couronne et al.   HAEMATOLOGICA

Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8+ T-cell memory formation and function

(2013) Megan L. Ives et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lung Parenchyma Surgery in Autosomal Dominant Hyper-IgE Syndrome

(2013) Alexandra F. Freeman et al.   JOURNAL OF CLINICAL IMMUNOLOGY

STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia

(2013) Zhi-Yuan Qiu et al.   Journal of Hematology & Oncology

STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia

(2013) R S Ohgami et al.   LEUKEMIA

Clinical Features, STAT3 Gene Mutations and Th17 Cell Analysis in Nine Children with Hyper-IgE Syndrome in Mainland China

(2013) L.-Y. Zhang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

(2013) Sina Haftchenary et al.   ACS Medicinal Chemistry Letters

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia

(2012) A. Jerez et al.   BLOOD

Functional STAT3 deficiency compromises the generation of human T follicular helper cells

(2012) C. S. Ma et al.   BLOOD

The language of SH2 domain interactions defines phosphotyrosine-mediated signal transduction

(2012) Bernard A. Liu et al.   FEBS LETTERS

STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway

(2012) Jianxin He et al.   JOURNAL OF BIOSCIENCES

STAT3 mutations are highly specific for large granular lymphocytic leukemia

(2012) A Fasan et al.   LEUKEMIA

Autosomal Dominant STAT3 Deficiency and Hyper-IgE Syndrome

(2012) Marie-Olivia Chandesris et al.   MEDICINE

Severe Growth Deficiency is Associated with STAT5b Mutations that Disrupt Protein Folding and Activity

(2012) Benjamin Varco-Merth et al.   MOLECULAR ENDOCRINOLOGY

SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia

(2012) Hanna L.M. Koskela et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of a novelSTAT3mutation in a patient with hyper-IgE syndrome

(2012) Trine H. Mogensen et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

The STAT5b Pathway Defect and Autoimmunity

(2012) Takahiro Kanai et al.   Frontiers in Immunology

Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism

(2011) Myunggi Baik et al.   Annals of the New York Academy of Sciences

High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia

(2011) W. Warsch et al.   BLOOD

Paucity of genotype–phenotype correlations in STAT3 mutation positive Hyper IgE Syndrome (HIES)

(2011) Jennifer Heimall et al.   CLINICAL IMMUNOLOGY

SH2-domain mutations in STAT3 in hyper-IgE syndrome patients result in impairment of IL-10 function

(2011) Mauro Giacomelli et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

(2011) Camilla Pilati et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Destructive pulmonary staphylococcal infection in a boy with hyper-IgE syndrome: a novel mutation in the signal transducer and activator of transcription 3 (STAT3) gene (p.Y657S)

(2010) Jin-yan Liu et al.   EUROPEAN JOURNAL OF PEDIATRICS

Diagnostic approach to the hyper-IgE syndromes: Immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis

(2010) Lena F. Schimke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome

(2010) Cristina Woellner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rapid Molecular Analysis of the STAT3 Gene in Job Syndrome of Hyper-IgE and Recurrent Infectious Diseases

(2010) Attila Kumánovics et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specification

(2009) Massimo Nichane et al.   EMBO JOURNAL

Acute promyelocytic leukemia harboring aSTAT5B-RARAfusion gene and a G596V missense mutation in the STAT5B SH2 domain of theSTAT5B-RARA

(2009) Eisaku Iwanaga et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Frequent STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma

(2009) M. TSUTSUI et al.   International Journal of Laboratory Hematology

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML

(2008) A. Sallmyr et al.   BLOOD

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25− effector T cells

(2008) Laura Passerini et al.   INTERNATIONAL IMMUNOLOGY

Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced TH17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome

(2008) Ellen D. Renner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Novel and recurrent STAT3 mutations in hyper-IgE syndrome patients from different ethnic groups

(2008) Hong Jiao et al.   MOLECULAR IMMUNOLOGY