Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents

Ceftriaxone prevents the neurodegeneration and decreased neurogenesis seen in a Parkinson’s disease rat model: An immunohistochemical and MRI study

(2016) Jun-Cheng Weng et al.   BEHAVIOURAL BRAIN RESEARCH

A randomized phase l pharmacokinetic study comparing SB4 and etanercept reference product (Enbrel®) in healthy subjects

(2016) Yoon Jung Lee et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Inhibiting HIF-1α Decreases Expression of TNF-α and Caspase-3 in Specific Brain Regions Exposed Kainic Acid-Induced Status Epilepticus

(2016) Jixue Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Perispinal Delivery of CNS Drugs

(2016) Edward Lewis Tobinick   CNS DRUGS

Treatment for Rheumatoid Arthritis and Risk of Alzheimer’s Disease: A Nested Case-Control Analysis

(2016) Richard C. Chou et al.   CNS DRUGS

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Thalidomide represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-κB/p38/JNK signaling

(2016) Tieying Song et al.   JOURNAL OF NEUROIMMUNOLOGY

Waiving in vivo studies for monoclonal antibody biosimilar development: National and global challenges

(2016) Kathryn Chapman et al.   mAbs

Age and Alzheimer’s disease gene expression profiles reversed by the glutamate modulator riluzole

(2016) A C Pereira et al.   MOLECULAR PSYCHIATRY

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

(2016) E Haroon et al.   MOLECULAR PSYCHIATRY

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

(2016) Lana M. Osborn et al.   PROGRESS IN NEUROBIOLOGY

GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii

(2016) Clément N. David et al.   PLoS Pathogens

A phase III randomised, double-blind, parallel-group study comparing SB4 with etanercept reference product in patients with active rheumatoid arthritis despite methotrexate therapy

(2015) Paul Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Synergistic effects of ceftriaxone and erythropoietin on neuronal and behavioral deficits in an MPTP-induced animal model of Parkinson’s disease dementia

(2015) Chiu-Ku Huang et al.   BEHAVIOURAL BRAIN RESEARCH

Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease

(2015) I A Clark et al.   BRITISH JOURNAL OF PHARMACOLOGY

A novel mechanism of neuroprotection: Blood glutamate grabber

(2015) José Castillo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Endotoxin Tolerance Inhibits Lyn and c-Src Phosphorylation and Association with Toll-Like Receptor 4 but Increases Expression and Activity of Protein Phosphatases

(2015) Yanbao Xiong et al.   Journal of Innate Immunity

Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression

(2015) Holly C. Hunsberger et al.   JOURNAL OF NEUROCHEMISTRY

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine

(2015) Michelle C. Potter et al.   JOURNAL OF NEUROVIROLOGY

Distinct Immune Responses in Resistant and Susceptible Strains of Mice during Neurovirulent Alphavirus Encephalomyelitis

(2015) Kirsten A. Kulcsar et al.   JOURNAL OF VIROLOGY

Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy

(2015) Ivan Soltesz et al.   NATURE REVIEWS NEUROSCIENCE

Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease

(2015) Joannee Zumkehr et al.   NEUROBIOLOGY OF AGING

Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

(2015) J. Butchart et al.   NEUROLOGY

Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria

(2015) A.C. Campos et al.   NEUROSCIENCE

TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

(2015) L. Probert   NEUROSCIENCE

Intra-amygdala microinjection of TNF-α impairs the auditory fear conditioning of rats via glutamate toxicity

(2015) He Jing et al.   NEUROSCIENCE RESEARCH

Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor

(2015) Elizabeth Gerard et al.   PAIN

Effects of cannabinoid and glutamate receptor antagonists and their interactions on learning and memory in male rats

(2015) Somayeh Barzegar et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

(2015) Emile B. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

(2015) Levi B. Wood et al.   Scientific Reports

Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer’s disease

(2014) Michael A Castello et al.   BMC Neurology

Immediate Neurological Recovery Following Perispinal Etanercept Years After Brain Injury

(2014) Edward Tobinick et al.   CLINICAL DRUG INVESTIGATION

Perispinal Etanercept for Post-Stroke Neurological and Cognitive Dysfunction: Scientific Rationale and Current Evidence

(2014) Tracey A. Ignatowski et al.   CNS DRUGS

Tyrosine phosphorylation in Toll-like receptor signaling

(2014) Saurabh Chattopadhyay et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment

(2014) M. Serpell et al.   EUROPEAN JOURNAL OF PAIN

Blood–brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

(2014) William M Pardridge   Expert Opinion on Drug Delivery

Dronabinol and chronic pain: importance of mechanistic considerations

(2014) Marjan de Vries et al.   EXPERT OPINION ON PHARMACOTHERAPY

Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease

(2014) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

A survey on “Trojan Horse” peptides: Opportunities, issues and controlled entry to “Troy”

(2014) Nian-Qiu Shi et al.   JOURNAL OF CONTROLLED RELEASE

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cannabinoids Inhibit HIV-1 Gp120-Mediated Insults in Brain Microvascular Endothelial Cells

(2014) T.-S. Lu et al.   JOURNAL OF IMMUNOLOGY

Etanercept Reduces Neuroinflammation and Lethality in Mouse Model of Japanese Encephalitis

(2014) Jing Ye et al.   JOURNAL OF INFECTIOUS DISEASES

Glutamate as a neurotransmitter in the healthy brain

(2014) Y. Zhou et al.   JOURNAL OF NEURAL TRANSMISSION

Glutamine and Antioxidants in the Critically Ill Patient

(2014) Daren K. Heyland et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

(2014) Gabriel Olmos et al.   MEDIATORS OF INFLAMMATION

The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model

(2014) Diana Fernández-Suárez et al.   NEUROBIOLOGY OF AGING

Endocannabinoids in Synaptic Plasticity and Neuroprotection

(2014) Jian-Yi Xu et al.   NEUROSCIENTIST

Perspectives on neuroinflammation and excitotoxicity: A neurotoxic conspiracy?

(2014) Barbara Viviani et al.   NEUROTOXICOLOGY

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential Regulation of Glutamate Transporter Subtypes by Pro-Inflammatory Cytokine TNF-α in Cortical Astrocytes from a Rat Model of Amyotrophic Lateral Sclerosis

(2014) Amélie O. Dumont et al.   PLoS One

Evolution of TNF-induced apoptosis reveals 550 My of functional conservation

(2014) Steven D. Quistad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice

(2014) David Cheng et al.   PSYCHOPHARMACOLOGY

Etanercept biosimilars

(2014) Valderilio F. Azevedo et al.   RHEUMATOLOGY INTERNATIONAL

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson’s disease

(2014) Akie Tanabe et al.   Frontiers in Cellular Neuroscience

The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

(2014) Senthilkumar S. Karuppagounder et al.   Scientific Reports

Etanercept attenuates traumatic brain injury in rats by reducing early microglial expression of tumor necrosis factor-α

(2013) Chung-Ching Chio et al.   BMC NEUROSCIENCE

Prospects for cannabinoid therapies in viral encephalitis

(2013) Marylou V. Solbrig et al.   BRAIN RESEARCH

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

(2013) M. L. Hebron et al.   HUMAN MOLECULAR GENETICS

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

(2013) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

Riluzole increases glutamate uptake by cultured C6 astroglial cells

(2013) Oscar P. Dall’Igna et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance

(2013) Irina Lonskaya et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase

(2013) Ling Ye et al.   JOURNAL OF NEUROCHEMISTRY

3,6′-dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation

(2013) Jeong Seon Yoon et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ceftriaxone Treatment after Traumatic Brain Injury Restores Expression of the Glutamate Transporter, GLT-1, Reduces Regional Gliosis, and Reduces Post-Traumatic Seizures in the Rat

(2013) Grant S. Goodrich et al.   JOURNAL OF NEUROTRAUMA

Learning and memory ... and the immune system

(2013) I. Marin et al.   LEARNING & MEMORY

Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model

(2013) Tanya Chotibut et al.   MOLECULAR NEUROBIOLOGY

Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

(2013) Kiran Bhaskar et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective effect of ceftriaxone in a rat model of traumatic brain injury

(2013) Changmeng Cui et al.   NEUROLOGICAL SCIENCES

Mechanisms of cannabidiol neuroprotection in hypoxic–ischemic newborn pigs: Role of 5HT1A and CB2 receptors

(2013) M. Ruth Pazos et al.   NEUROPHARMACOLOGY

Neuroprotective effect of ceftriaxone on the penumbra in a rat venous ischemia model

(2013) T. Inui et al.   NEUROSCIENCE

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?

(2012) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

Does tumor necrosis factor-alpha (TNF-α) play a role in post-chemotherapy cerebral dysfunction?

(2012) Patricia A. Ganz et al.   BRAIN BEHAVIOR AND IMMUNITY

Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors

(2012) Shelli Kesler et al.   BRAIN BEHAVIOR AND IMMUNITY

Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury

(2012) Edward Tobinick et al.   CNS DRUGS

The Early Involvement of the Innate Immunity in the Pathogenesis of Lateonset Alzheimers Disease: Neuropathological, Epidemiological and Genetic Evidence

(2012) P. Eikelenboom et al.   Current Alzheimer Research

Deciphering the Physiology Underlying the Rapid Clinical Effects of Perispinal Etanercept in Alzheimers Disease

(2012) Edward Tobinick   Current Alzheimer Research

The therapeutic potential of the endocannabinoid system for Alzheimer's disease

(2012) Tim Karl et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Self-induced accumulation of glutamate in striatal astrocytes and basal ganglia excitotoxicity

(2012) Ingrid Morales et al.   GLIA

Brain Protection from Stroke with Intravenous TNFα Decoy Receptor-Trojan Horse Fusion Protein

(2012) Rachita K Sumbria et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nilotinib protects the murine liver from ischemia/reperfusion injury

(2012) Lee M. Ocuin et al.   JOURNAL OF HEPATOLOGY

IL-4 in the Brain: A Cytokine To Remember

(2012) Sachin P. Gadani et al.   JOURNAL OF IMMUNOLOGY

Non-physiological amino acid (NPAA) therapy targeting brain phenylalanine reduction: pilot studies in PAH ENU2 mice

(2012) Kara R. Vogel et al.   JOURNAL OF INHERITED METABOLIC DISEASE

3,6′-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit

(2012) Isabella Russo et al.   JOURNAL OF NEUROCHEMISTRY

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

(2012) S Prasad Gabbita et al.   Journal of Neuroinflammation

Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer’s disease

(2012) Gunjan Dhawan et al.   Journal of Neuroinflammation

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation

(2012) Karim Belarbi et al.   Journal of Neuroinflammation

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

(2012) David Tweedie et al.   Journal of Neuroinflammation

The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury

(2012) Jing Wei et al.   Journal of Trauma and Acute Care Surgery

Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic–ischemic brain injury in rats

(2012) Silvia Carloni et al.   PEDIATRIC RESEARCH

Ceftriaxone Ameliorates Motor Deficits and Protects Dopaminergic Neurons in 6-Hydroxydopamine-Lesioned Rats

(2011) T. C. H. Leung et al.   ACS Chemical Neuroscience

Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks

(2011) Karim Belarbi et al.   BRAIN BEHAVIOR AND IMMUNITY

Rapid Improvement of Chronic Stroke Deficits after Perispinal Etanercept

(2011) Edward Tobinick   CNS DRUGS

Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity

(2011) Christian Bonansco et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-α signaling and contributes to neuronal death

(2011) Chun-Jung Chen et al.   GLIA

Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation

(2011) Y. C. Chung et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor-α synthesis inhibitor, 3,6′-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice

(2011) Renana Baratz et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Cannabinoid Type 2 Receptors Inhibits HIV-1 Envelope Glycoprotein gp120-Induced Synapse Loss

(2011) H. J. Kim et al.   MOLECULAR PHARMACOLOGY

Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab

(2011) Jacqueline M Benson et al.   NATURE BIOTECHNOLOGY

Amyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism

(2011) Gunjan Dhawan et al.   NEUROBIOLOGY OF AGING

Riluzole elevates GLT-1 activity and levels in striatal astrocytes

(2011) Marica Carbone et al.   NEUROCHEMISTRY INTERNATIONAL

Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults

(2011) X. Chen et al.   NEUROSCIENCE

Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

(2011) Andreas Hess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nilotinib ameliorates lipopolysaccharide-induced acute lung injury in rats

(2011) Dina S. El-Agamy   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of TNF blockers and other targeted therapies in rare refractory immune-mediated inflammatory diseases: evidence-based or rational?

(2010) D. Baeten et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased glutamate/glutamine compounds in the brains of patients with fibromyalgia: A magnetic resonance spectroscopy study

(2010) Manuel Valdés et al.   ARTHRITIS AND RHEUMATISM

Increased levels of glutamate in the central nervous system are associated with behavioral symptoms in experimental malaria

(2010) A.S. Miranda et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain

(2010) Josée Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glutamine in Critical Illness: The Time Has Come, The Time Is Now

(2010) Lindsay-Rae B. Weitzel et al.   CRITICAL CARE CLINICS

Brain-Penetrating Tumor Necrosis Factor Decoy Receptor in the Mouse

(2010) Q.-H. Zhou et al.   DRUG METABOLISM AND DISPOSITION

The endocannabinoid system in gp120-mediated insults and HIV-associated dementia

(2010) Monica Bari et al.   EXPERIMENTAL NEUROLOGY

Improvement of cognition, a potential benefit of anti-TNF therapy in elderly patients with rheumatoid arthritis

(2010) Yi-Ming Chen et al.   JOINT BONE SPINE

Therapeutic evaluation of etanercept in a model of traumatic brain injury

(2010) Chung-Ching Chio et al.   JOURNAL OF NEUROCHEMISTRY

Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease

(2010) Ashley S Harms et al.   MOLECULAR THERAPY

Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

(2010) Christopher C. Rowe et al.   NEUROBIOLOGY OF AGING

The roles of TNF in brain dysfunction and disease

(2010) Ian A. Clark et al.   PHARMACOLOGY & THERAPEUTICS

Cannabinoid-Mediated Inhibition of Recurrent Excitatory Circuitry in the Dentate Gyrus in a Mouse Model of Temporal Lobe Epilepsy

(2010) Muthu D. Bhaskaran et al.   PLoS One

Tumor necrosis factor-  triggers a cytokine cascade yielding postoperative cognitive decline

(2010) N. Terrando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF-α in Hypothalamic Paraventricular Nucleus Contributes to Sympathoexcitation in Heart Failure by Modulating AT1 Receptor and Neurotransmitters

(2010) Yu-Ming Kang et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Randomized, Double-blind, Placebo-controlled, Dose-response, and Preclinical Safety Study of Transforaminal Epidural Etanercept for the Treatment of Sciatica

(2009) Steven P. Cohen et al.   ANESTHESIOLOGY

Tumor necrosis factor-α modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis

(2009) Jessica Carmen et al.   BRAIN RESEARCH

Brain tumour necrosis factor-  modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure

(2009) Y.-M. Kang et al.   CARDIOVASCULAR RESEARCH

Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes

(2009) Dariush Mokhtari et al.   CLINICAL SCIENCE

WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease

(2009) David A. Price et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches

(2009) Rudy Castellani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Radiation-Induced Astrogliosis and Blood-Brain Barrier Damage Can Be Abrogated Using Anti-TNF Treatment

(2009) Christy M. Wilson et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Nilotinib inhibits the Src-family kinase LCK and T-cell function in vitro

(2009) Stephen J. Blake et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain

(2009) Jeremy R. Johnson et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain

(2009) S. G. Kinsey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nilotinib: A second-generation tyrosine kinase inhibitor for chronic myeloid leukemia

(2009) Massimo Breccia et al.   LEUKEMIA RESEARCH

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Blockade of Glutamate Release from Microglia Attenuates Experimental Autoimmune Encephalomyelitis in Mice

(2009) Jin Shijie et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

Perispinal etanercept for neuroinflammatory disorders

(2008) Edward Tobinick   DRUG DISCOVERY TODAY

Blockade of microglial glutamate release protects against ischemic brain injury

(2008) Hideyuki Takeuchi et al.   EXPERIMENTAL NEUROLOGY

Ca2+ entry through TRPC1 channels contributes to intracellular Ca2+ dynamics and consequent glutamate release from rat astrocytes

(2008) Erik B. Malarkey et al.   GLIA

Differential involvement of TNFα in hypoxic suppression of astrocyte glutamate transporters

(2008) Hannah E. Boycott et al.   GLIA

Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes

(2008) Seok-Geun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis

(2008) Natalie A. Prow et al.   JOURNAL OF NEUROCHEMISTRY

Perispinal etanercept: Potential as an Alzheimer therapeutic

(2008) W Sue T Griffin   Journal of Neuroinflammation

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

(2008) Edward L Tobinick et al.   Journal of Neuroinflammation

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

The Effects of Riluzole on Neurological, Brain Biochemical, and Histological Changes in Early and Late Term of Sepsis in Rats

(2008) Hale Z. Toklu et al.   JOURNAL OF SURGICAL RESEARCH

Synaptic vesicle protein trafficking at the glutamate synapse

(2008) M.S. Santos et al.   NEUROSCIENCE

The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats

(2007) S M Rawls et al.   BRITISH JOURNAL OF PHARMACOLOGY

Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1

(2007) Elena Fumagalli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY