Blood–brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Blood-Brain Barrier Molecular Trojan Horse Enables Imaging of Brain Uptake of Radioiodinated Recombinant Protein in the Rhesus Monkey

(2013) Ruben J. Boado et al.   BIOCONJUGATE CHEMISTRY

Combination stroke therapy in the mouse with blood–brain barrier penetrating IgG–GDNF and IgG–TNF decoy receptor fusion proteins

(2013) Rachita K. Sumbria et al.   BRAIN RESEARCH

Disaggregation of Amyloid Plaque in Brain of Alzheimer’s Disease Transgenic Mice with Daily Subcutaneous Administration of a Tetravalent Bispecific Antibody That Targets the Transferrin Receptor and the Abeta Amyloid Peptide

(2013) Rachita K. Sumbria et al.   MOLECULAR PHARMACEUTICS

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

IgG-Enzyme Fusion Protein: Pharmacokinetics and Anti-Drug Antibody Response in Rhesus Monkeys

(2012) Ruben J. Boado et al.   BIOCONJUGATE CHEMISTRY

Brain Protection from Stroke with Intravenous TNFα Decoy Receptor-Trojan Horse Fusion Protein

(2012) Rachita K Sumbria et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Delivery of a Peptide Radiopharmaceutical to Brain with an IgG-Avidin Fusion Protein

(2011) Qing-Hui Zhou et al.   BIOCONJUGATE CHEMISTRY

Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson's disease in the mouse

(2011) Qing-Hui Zhou et al.   BRAIN RESEARCH

Novel18F-Labeled Benzofuran Derivatives with Improved Properties for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques in Alzheimer’s Brains

(2011) Masahiro Ono et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Reversal of Lysosomal Storage in Brain of Adult MPS-I Mice with Intravenous Trojan Horse-Iduronidase Fusion Protein

(2011) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-  Production in Vivo

(2011) J. K. Atwal et al.   Science Translational Medicine

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

A Single Ascending Dose Study of Bapineuzumab in Patients With Alzheimer Disease

(2010) Ronald S. Black et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood–brain barrier

(2010) Ailing Fu et al.   BRAIN RESEARCH

Monoclonal Antibody-Glial-Derived Neurotrophic Factor Fusion Protein Penetrates the Blood-Brain Barrier in the Mouse

(2010) Q.-H. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Brain-Penetrating Tumor Necrosis Factor Decoy Receptor in the Mouse

(2010) Q.-H. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein

(2010) Ruben J. Boado et al.   JOURNAL OF BIOTECHNOLOGY

Re-Engineering Erythropoietin as an IgG Fusion Protein That Penetrates the Blood−Brain Barrier in the Mouse

(2010) Qing-Hui Zhou et al.   MOLECULAR PHARMACEUTICS

Genetic engineering of IgG-glucuronidase fusion proteins

(2009) Ruben J. Boado et al.   JOURNAL OF DRUG TARGETING

A radiotracer method to study efflux transport of iodide liberated from thyroid hormones via deiodination metabolism in the brain

(2009) Toshimitsu Okamura et al.   LIFE SCIENCES

Pharmacokinetics and Brain Uptake of a Genetically Engineered Bifunctional Fusion Antibody Targeting the Mouse Transferrin Receptor

(2009) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

Genetic Engineering, Expression, and Activity of a Chimeric Monoclonal Antibody−Avidin Fusion Protein for Receptor-Mediated Delivery of Biotinylated Drugs in Humans

(2008) Ruben J. Boado et al.   BIOCONJUGATE CHEMISTRY

Erythropoietins: A common mechanism of action

(2008) Steve Elliott et al.   EXPERIMENTAL HEMATOLOGY

Antibody Capture of Soluble Aβ Does Not Reduce Cortical Aβ Amyloidosis in the PDAPP Mouse

(2008) Peter Seubert et al.   Neurodegenerative Diseases