Article
Physiology
Mojtaba Madadi Asl, Atefeh Asadi, Jamil Enayati, Alireza Valizadeh
Summary: Parkinson's disease is a neurodegenerative brain disorder associated with dysfunction of the basal ganglia circuitry, leading to pathological strengthening of pallido-subthalamic synapses and abnormal synchronized neuronal activity. Inhibitory spike-timing-dependent plasticity at these synapses may contribute to the pathological changes observed in PD, shaping bistable activity-connectivity states in the GPe-STN network.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Xingzhi He, Jiarui Li, Guangjun Zhou, Jing Yang, Sam McKenzie, Yanjun Li, Wenwen Li, Jun Yu, Yang Wang, Jing Qu, Zhiying Wu, Hailan Hu, Shumin Duan, Huan Ma
Summary: This study shows a positive correlation between hippocampal oscillatory strength and excitatory monosynaptic drive onto inhibitory neurons in freely behaving mice. By manipulating experience-dependent E -> I synaptic input/plasticity, the researchers were able to demonstrate its role in memory function. Deleting a specific protein affected long-term memory and brain wave rhythms.
Article
Neurosciences
Maithe Loisy, Guillaume Bouisset, Sebastien Lopez, Maud Muller, Alena Spitsyn, Jeanne Duval, Rebecca Ann Piskorowski, Laure Verret, Vivien Chevaleyre
Summary: This study reveals a novel inhibitory plasticity mediated by cannabinoid type 1 receptor activation (CB1R-iLTD) in the CA2 region of the hippocampus, which plays a crucial role in social memory formation. The study also demonstrates that the previous induction of Delta-opioid receptor-mediated long-term depression (DOR-iLTDs) is necessary for the CB1R-iLTD to occur. The findings provide insights into the interplay between inhibitory plasticities and a new mechanism for social memory formation.
Article
Clinical Neurology
Mei Hu, Dexiao Zhu, Jian Zhang, Fei Gao, Jack Hashem, Philip Kingsley, Lawrence J. Marnett, Ken Mackie, Chu Chen
Summary: Traumatic brain injury is a risk factor for Alzheimer's disease and dementia. In this study, the researchers found that inhibiting monoacylglycerol lipase can reduce neuropathology caused by traumatic brain injury. The neuroprotective effects are mainly due to the inhibition of 2-arachidonoylglycerol metabolism in astrocytes, and not in neurons.
Article
Biochemistry & Molecular Biology
Chang Liu, Shanshan Guan, Jingwen E, Zhijie Yang, Xinyue Zhang, Jianan Ju, Song Wang, Hao Zhang
Summary: This study investigated the inhibitory mechanism and binding modes of four aryl formyl piperidine derivative inhibitors with different 1-substituents to MAGL using molecular docking and molecular dynamics simulations. Different 1-substituted groups caused significant conformational changes in the enzyme's lid domain and resulted in varying interactions with the inhibitor, affecting the binding strength and level of inhibition.
Article
Biochemistry & Molecular Biology
Grzegorz Wiera, Katarzyna Lebida, Anna Maria Lech, Patrycja Brzdak, Inge Van Hove, Lies De Groef, Lieve Moons, Enrica Maria Petrini, Andrea Barberis, Jerzy W. Mozrzymas
Summary: This study demonstrates that MMP3 plays a key role in iLTP mechanisms, affecting behaviors that in part depend on GABAergic plasticity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Neurosciences
Dexiao Zhu, Jian Zhang, Fei Gao, Mei Hu, Jack Hashem, Chu Chen
Summary: 2-AG, the most abundant endocannabinoid, has anti-inflammatory and neuroprotective properties. Inhibition of its degradation enzyme MAGL improves synaptic and cognitive functions in neurodegenerative disease models. However, the molecular mechanisms behind this enhancement are still unclear.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Cell Biology
Dexiao Zhu, Fei Gao, Chu Chen
Summary: Endocannabinoids play a crucial role in TBI-induced AD, with the inhibition of 2-AG metabolism helping to alleviate neuropathology and improve cognitive function.
Article
Neurosciences
Margarita Anisimova, Bas van Bommel, Rui Wang, Marina Mikhaylova, Joern Simon Wiegert, Thomas G. Oertner, Christine E. Gee
Summary: The study uses optogenetic stimulation to induce STDP and observes timing-dependent depression and potentiation. This study does not require electrodes and results suggest that synaptic depression after anticausal activation is a transient phenomenon.
Review
Neurosciences
Yanis Inglebert, Dominique Debanne
Summary: The importance of considering physiological levels of extracellular calcium concentration in studying functional plasticity is discussed in this study.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Wanqiu Niu, Yanhong Duan, Yu Kang, Xiaohua Cao, Qingsheng Xue
Summary: This study investigated the effect of propofol on fear memory extinction and synaptic plasticity in a PTSD mice model. The results showed that propofol can accelerate fear memory extinction and restore impaired synaptic plasticity in the hippocampus of PTSD mice.
Article
Biochemistry & Molecular Biology
Irene Martinez-Gallego, Antonio Rodriguez-Moreno, Yuniesky Andrade-Talavera
Summary: In this article, the involvement of group I mGluRs in STDP and their possible role as coincidence detectors are briefly reviewed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yanjuan Cao, Wen Sun, Chang Liu, Zihui Zhou, Zongli Deng, Mingjie Zhang, Meng Yan, Xiaoxing Yin, Xia Zhu
Summary: Diabetic encephalopathy (DE) is a central nervous complication of diabetes mellitus characterized by cognitive impairment and neurochemical abnormalities. This study suggests that resveratrol may improve cognitive impairment in DE by modulating mitochondrial function through inhibiting PDE4D.
BRAIN RESEARCH BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Suk-Young Song, Soonil Pyo, Sungchul Choi, Hee Sang Oh, Jung Hwa Seo, Ji Hea Yu, Ahreum Baek, Yoon-Kyum Shin, Hoo Young Lee, Ja Young Choi, Sung-Rae Cho
Summary: Environmental enrichment (EE) has a significant therapeutic effect on HIE, upregulating the expression of the Ca-v 2.1 channel and presynaptic proteins, leading to improvements in motor and cognitive performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Leonidas M. A. Richter, Julijana Gjorgjieva
Summary: This study investigates the impact of deprivation-induced synaptic changes on excitatory and inhibitory firing rates. It reveals that a single interneuron subtype can only co-modulate the firing rates together, while independent modulation observed in experiments requires strong feedback from a second interneuron subtype.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)