Review
Nutrition & Dietetics
Aileen Hill, Gunnar Elke, Arved Weimann
Summary: Nutritional therapy for critically ill patients should be tailored to individual patients, focusing on the phase of critical illness, metabolic tolerance, leading symptoms, and comorbidities. Personalized and disease-specific nutritional therapy in the ICU requires an interdisciplinary approach and frequent reevaluation for optimal clinical outcomes.
Article
Nutrition & Dietetics
Marek Welna, Barbara Adamik, Andrzej Kubler, Waldemar Gozdzik
Summary: The Nutrition Risk in Critically Ill score (NUTRIC) is an important assessment tool in the ICU for predicting mortality and resource utilization in patients with sepsis. The score showed good predictive value for mortality and was associated with increased ICU resource utilization and nursing workload.
Article
Multidisciplinary Sciences
Magdalena Mierzchala-Pasierb, Malgorzata Lipinska-Gediga, Mariusz G. Fleszar, Lukasz Lewandowski, Pawel Serek, Sylwia Placzkowska, Malgorzata Krzystek-Korpacka
Summary: The study compared patterns of urine and serum amino acids in sepsis, septic shock, and survival, identifying significant differences in concentrations of specific amino acids at different stages. This suggests that urine and serum amino acids could potentially be used to assess and diagnose sepsis or septic shock in patients.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Jun-Kwon Cha, Hyung-Sook Kim, Eun-Ji Kim, Eun-Sook Lee, Jae-Ho Lee, In-Ae Song
Summary: The initial nutritional delivery policy and route of nutrition delivery may have an impact on the clinical outcomes of patients with sepsis. Higher protein intake during the first week of sepsis onset is associated with lower in-hospital mortality, while higher energy intake is associated with lower 30-day mortality. Additionally, in patients with a high modified nutrition risk in the critically ill score, enteral feeding with supplemental parenteral nutrition is superior to other routes of nutrition delivery and is associated with lower mortality.
Article
Nutrition & Dietetics
Efrossini Briassouli, Marianna Tzanoudaki, Dimitris Goukos, Kostas Vardas, Panagiotis Briassoulis, Stavroula Ilia, Maria Kanariou, Christina Routsi, Serafim Nanas, George L. Daikos, George Briassoulis
Summary: The study aimed to evaluate the effects of lipopolysaccharide (LPS) or heat shock (HS) induction and glutamine modulation on heat shock protein-90 alpha (HSP90α) and cytokines in peripheral blood mononuclear cells (PBMCs). Heat shock increased HSP90α mRNA and mHSP90α in all groups, while LPS induced mHSP90α and lHSP90α protein expression. Glutamine enhanced LPS-induction of MCP-1 in all groups. Future research should further investigate the impact of glutamine and temperature modulation on HSP90α and MCP-1 pathways in sepsis and trauma.
Article
Multidisciplinary Sciences
Julian F. Kochanowicz, Agnieszka Nowicka, Salwan R. Al-Saad, Lukasz M. Karbowski, Janusz Gadzinowski, Dawid Szpecht
Summary: This study compared the risk factors and characteristics of neonatal sepsis patients based on the type of catheter used and birth weight classification. The results showed that infants with low birth weight and those requiring prolonged parenteral nutrition were more likely to develop catheter-related bloodstream infections. The type of venous catheter used did not affect blood culture results, and the etiology of sepsis did not differ between infants with different birth weights.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jan Heil, Martin Schlapfer
Summary: The article introduces a simple, reliable, and reproducible animal model for sepsis treatment research. The model operates based on strict protocols to simulate the process of infection treatment in clinical intensive care units.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Pediatrics
Gabriella Bottari, Mariangela Caruso, Emanuel Paionni, Maia De Luca, Lorenza Romani, Mara Pisani, Annalisa Grandin, Livia Gargiullo, Giorgio Zampini, Chiara Gagliardi, Danilo Alunni Fegatelli, Annarita Vestri, Laura Lancella, Ottavia Porzio, Andrea Onetti Muda, Alberto Villani, Marta Ciofi Degli Atti, Massimiliano Raponi, Corrado Cecchetti
Summary: PSP can differentiate sepsis from non-infectious systemic inflammation, but our findings require validation in a larger pediatric population.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Article
Agriculture, Dairy & Animal Science
Bolin Zhang, Huilei Sun, Zewei Sun, Ning Liu, Rujie Liu, Qingzhen Zhong
Summary: Glutamine (Gln) addition protects porcine epithelial cells (IPEC-J2) from apoptosis and damage to the mucosal barrier induced by heat stress (HS), potentially through the mitochondrial apoptosis pathway mediated by heat shock protein 70 (HSP70). These findings provide a possible theoretical basis for mitigating HS-induced damage to porcine intestinal epithelium and offer insights for developing nutritional strategies to alleviate the negative effects of HS on farmed animals.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Tarek R. Hazwani, Wesam Bin Obaid, Fatimah Alowirdi, Rahaf Alsomali, Hamza Alali, Alaa Alsadoon, Moudi Alhamwah, Sara Alsubaiel, Bassam Alomar, Ramesh Vishwakarma, Yasser M. Kazzaz
Summary: In this retrospective cohort study in pediatric patients with severe sepsis/septic shock, thrombocytopenia was found to be more associated with non-bacterial sepsis/septic shock, indicating a potential better outcome in these patients. The presence of multiorgan dysfunction syndrome at the onset of sepsis was more prevalent in patients without thrombocytopenia, while the progression of MODS over three days remained consistent in both groups. Thrombocytopenia may serve as a prognostic marker for sepsis in pediatric patients.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Computer Science, Theory & Methods
Chang Liu, Zhenjie Yao, Pengfei Liu, Yanhui Tu, Hu Chen, Haibo Cheng, Lixin Xie, Kun Xiao
Summary: This study developed an early warning model for MODS using machine learning algorithms, which can predict the probability of MODS 12 hours in advance, quantify the risk factors, and automatically recommend interventions. The results showed that the SuperLearner model had the best prediction performance and high accuracy and utility_score.
JOURNAL OF BIG DATA
(2023)
Review
Cardiac & Cardiovascular Systems
Yichi Zhang, Michael T. McCurdy, Jonathan Ludmir
Summary: The management of septic shock in the cardiac intensive care unit (CICU) is challenging due to the complex interaction of pathophysiology between vasodilatory and cardiogenic shock. Familiarity with contemporary clinical evidence is crucial for addressing the wide range of complications that can arise.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Multidisciplinary Sciences
Rongjun Zou, Jun Tao, Junxiong Qiu, Huimin Lu, Jianhua Wu, Hang Zhu, Ruibing Li, David Mui, Sam Toan, Xing Chang, Hao Zhou, Xiaoping Fan
Summary: This study aimed to elucidate the functional importance of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in sepsis-related multiple organ dysfunction syndrome (MODS). The results showed that deletion of DNA-PKcs improved mitochondrial function and attenuated organ damage in sepsis. Strategies targeting DNA-PKcs expression or activity may be valuable therapeutic options for preventing or reducing mitochondrial dysfunction and organ damage associated with sepsis-induced MODS.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Neurosciences
Jin Wang, Xinjian Lu, Kang Zheng, Liang Jing
Summary: The study demonstrated that Gln can alleviate brain damage in septic rats, potentially through the increase of protein O-GlcNAc modification.
Article
Agriculture, Dairy & Animal Science
Yves Kamali, Yong Ho Jo, Won Seob Kim, Jalil Ghassemi Nejad, Jae-Sung Lee, Hong Gu Lee
Summary: This study investigated the effects of L-glutamine supplementation on growth performance, physiological traits, heat shock proteins (HSPs), and gene expression related to muscle and adipose tissue development in Hanwoo steers under heat stress conditions. The results showed that Gln supplementation did not significantly affect growth performance and gene expression, but increased the number of immune cells and decreased HSP90 expression in the hair follicle, suggesting a potential reduction in heat stress.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2022)
Article
Critical Care Medicine
Dhruv Sarma, Jacob C. Jentzer
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Gurleen Kaur, David D. Berg
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Leon Zhou, Brandon M. Wiley
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Emily K. Zern, Rachel C. Frank, Evin Yucel
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Damien Smith, Benjamin B. Kenigsberg
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Gozde Demiralp, Robert T. Arrigo, Christopher Cassara, Maryl R. Johnson
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Katie P. Truong, James N. Kirkpatrick
Summary: The increasing use of MCS in advanced heart failure patients has led to a greater need for end-of-life management, including MCS device withdrawal and advance care planning. Preparedness planning and palliative care services are important in ensuring a smooth transition to the end of life. Ethical dilemmas can complicate end-of-life care, and withdrawal/deactivation should follow a set protocol that addresses psychosocial/spiritual needs and patient comfort.
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Brent Klinkhammer, Taya V. Glotzer
CRITICAL CARE CLINICS
(2024)
Article
Critical Care Medicine
Jacob B. Pierce, Willard N. Applefeld, Balimkiz Senman, Daniel B. Loriaux, Patrick R. Lawler, Jason N. Katz
Summary: Due to the increasing medical complexity of patients, heterogeneity of treatment effects in broad clinical syndromes, and significant competing risks for morbidity and mortality, future clinical trials in the CICU are likely to benefit from innovative approaches to trial design, analysis, and execution, such as incorporating novel trial endpoints, Bayesian analysis strategies, trial networks and clinical registries, adaptive platform trials, and comprehensive research programs. It will be crucial for the authors as a field to articulate priorities for future research and embrace these novel techniques that will ultimately help take better care of patients in the contemporary CICU.
CRITICAL CARE CLINICS
(2024)
