The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils
出版年份 2022 全文链接
标题
The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils
作者
关键词
-
出版物
Nature Communications
Volume 13, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-09-14
DOI
10.1038/s41467-022-32797-w
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Binding Sites of a Positron Emission Tomography Imaging Agent in Alzheimer’s β-Amyloid Fibrils Studied Using 19F Solid-State NMR
- (2022) Pu Duan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial
- (2022) Johannes Levin et al. EBioMedicine
- Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein
- (2022) Benedikt Frieg et al. Communications Biology
- Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy
- (2021) Sofia Lövestam et al. FEBS Open Bio
- α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease
- (2021) Tracy A. Cole et al. JCI Insight
- Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607
- (2021) Yang Shi et al. ACTA NEUROPATHOLOGICA
- Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes
- (2021) Leif Antonschmidt et al. Science Advances
- Mapping the Binding Interface of PET Tracer Molecules and Alzheimer Disease Aβ Fibrils by Using MAS Solid‐State NMR Spectroscopy
- (2020) Zheng Niu et al. CHEMBIOCHEM
- 17O NMR studies of yeast ubiquitin in aqueous solution and in the solid state
- (2020) Binyang Lin et al. CHEMBIOCHEM
- [11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates
- (2020) Laura Kuebler et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Correcting for magnetic field drift in magic-angle spinning NMR datasets
- (2019) Eszter E. Najbauer et al. JOURNAL OF MAGNETIC RESONANCE
- Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model
- (2019) Michal Wegrzynowicz et al. ACTA NEUROPATHOLOGICA
- The physiological role of α‐synuclein and its relationship to Parkinson’s Disease
- (2019) David Sulzer et al. JOURNAL OF NEUROCHEMISTRY
- Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
- (2019) Sarah H. Shahmoradian et al. NATURE NEUROSCIENCE
- Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs
- (2019) David R. Boyer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
- (2019) Ricardo Guerrero-Ferreira et al. eLife
- Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
- (2018) Jordi Pujols et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy
- (2018) Antonio Heras-Garvin et al. MOVEMENT DISORDERS
- Water Distribution, Dynamics, and Interactions with Alzheimer’s β-Amyloid Fibrils Investigated by Solid-State NMR
- (2017) Tuo Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Computer Modeling of Halogen Bonds and Other σ-Hole Interactions
- (2016) Michal H. Kolář et al. CHEMICAL REVIEWS
- Transmembrane Potential Modeling: Comparison between Methods of Constant Electric Field and Ion Imbalance
- (2016) Josef Melcr et al. Journal of Chemical Theory and Computation
- Synucleinopathies: past, present and future
- (2016) M. G. Spillantini et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies
- (2015) Jens Wagner et al. ACTA NEUROPATHOLOGICA
- Efficient Dynamic Nuclear Polarization at 800 MHz/527 GHz with Trityl-Nitroxide Biradicals
- (2015) Guinevere Mathies et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates
- (2015) Andreas A. Deeg et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide
- (2015) Elke Prade et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Multiple-System Atrophy
- (2015) Alessandra Fanciulli et al. NEW ENGLAND JOURNAL OF MEDICINE
- The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset
- (2014) Johannes Levin et al. ACTA NEUROPATHOLOGICA
- NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy
- (2014) Woonghee Lee et al. BIOINFORMATICS
- Rapid Proton-Detected NMR Assignment for Proteins with Fast Magic Angle Spinning
- (2014) Emeline Barbet-Massin et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
- (2013) Jens Wagner et al. ACTA NEUROPATHOLOGICA
- GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit
- (2013) Sander Pronk et al. BIOINFORMATICS
- g_contacts: Fast contact search in bio-molecular ensemble data
- (2013) Christian Blau et al. COMPUTER PHYSICS COMMUNICATIONS
- Structural Factors Controlling the Spin–Spin Exchange Coupling: EPR Spectroscopic Studies of Highly Asymmetric Trityl–Nitroxide Biradicals
- (2013) Yangping Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Another Piece of the Membrane Puzzle: Extending Slipids Further
- (2012) Joakim P. M. Jämbeck et al. Journal of Chemical Theory and Computation
- An Extension and Further Validation of an All-Atomistic Force Field for Biological Membranes
- (2012) Joakim P. M. Jämbeck et al. Journal of Chemical Theory and Computation
- Derivation and Systematic Validation of a Refined All-Atom Force Field for Phosphatidylcholine Lipids
- (2012) Joakim P. M. Jämbeck et al. JOURNAL OF PHYSICAL CHEMISTRY B
- The Amyloid-Congo Red Interface at Atomic Resolution
- (2011) Anne K. Schütz et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Protein 3D structure determination by high-resolution solid-state NMR
- (2010) Antoine Loquet et al. COMPTES RENDUS CHIMIE
- Improved side-chain torsion potentials for the Amber ff99SB protein force field
- (2010) Kresten Lindorff-Larsen et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Characterization of different water pools in solid-state NMR protein samples
- (2009) Anja Böckmann et al. JOURNAL OF BIOMOLECULAR NMR
- Optimized Molecular Dynamics Force Fields Applied to the Helix−Coil Transition of Polypeptides
- (2009) Robert B. Best et al. JOURNAL OF PHYSICAL CHEMISTRY B
- P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation
- (2007) Berk Hess Journal of Chemical Theory and Computation
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