Binding Sites of a Positron Emission Tomography Imaging Agent in Alzheimer’s β-Amyloid Fibrils Studied Using 19F Solid-State NMR

Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

(2021) Yang Shi et al.   ACTA NEUROPATHOLOGICA

From Angstroms to Nanometers: Measuring Interatomic Distances by Solid-State NMR

(2021) Alexander A. Shcherbakov et al.   CHEMICAL REVIEWS

Computational Insight into the Binding Profile of the Second-Generation PET Tracer PI2620 with Tau Fibrils

(2020) Guanglin Kuang et al.   ACS Chemical Neuroscience

Two-dimensional 19F–13C correlation NMR for 19F resonance assignment of fluorinated proteins

(2020) Alexander A. Shcherbakov et al.   JOURNAL OF BIOMOLECULAR NMR

Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I

(2020) Alberto Ceccon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain

(2020) Axel Abelein et al.   Scientific Reports

Mapping the Binding Interface of PET Tracer Molecules and Alzheimer Disease Aβ Fibrils by Using MAS Solid‐State NMR Spectroscopy

(2020) Zheng Niu et al.   CHEMBIOCHEM

Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer’s disease

(2020) Milos D. Ikonomovic et al.   ACTA NEUROPATHOLOGICA

19F Dynamic Nuclear Polarization at Fast Magic Angle Spinning for NMR of HIV-1 Capsid Protein Assemblies

(2019) Manman Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Free Energy Profile for Penetration of Pittsburgh Compound-B into the Amyloid β Fibril

(2019) Rongfeng Zou et al.   ACS Chemical Neuroscience

High-Sensitivity Detection of Nanometer 1H–19F Distances for Protein Structure Determination by 1H-Detected Fast MAS NMR

(2019) Alexander A. Shcherbakov et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Observation of β-Amyloid Peptide Oligomerization by Pressure-Jump NMR Spectroscopy

(2019) C. Ashley Barnes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

(2019) Marius Kollmer et al.   Nature Communications

Rapid measurement of long-range distances in proteins by multidimensional 13C–19F REDOR NMR under fast magic-angle spinning

(2018) Alexander A. Shcherbakov et al.   JOURNAL OF BIOMOLECULAR NMR

Fast Magic-Angle-Spinning 19F Spin Exchange NMR for Determining Nanometer 19F–19F Distances in Proteins and Pharmaceutical Compounds

(2018) Matthias Roos et al.   JOURNAL OF PHYSICAL CHEMISTRY B

REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment

(2018) Hao Yang et al.   ACS Central Science

Fast Magic Angle Spinning ¹⁹F NMR of HIV-1 Capsid Protein Assemblies

(2018) Mingzhang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Large-scale prediction of binding affinity in protein-small ligand complexes: the PRODIGY-LIG web server

(2018) Anna Vangone et al.   BIOINFORMATICS

Determination of Long-Range Distances by Fast Magic-Angle-Spinning Radiofrequency-Driven 19F–19F Dipolar Recoupling NMR

(2018) Matthias Roos et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Water Distribution, Dynamics, and Interactions with Alzheimer’s β-Amyloid Fibrils Investigated by Solid-State NMR

(2017) Tuo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Efficient protein production inspired by how spiders make silk

(2017) Nina Kronqvist et al.   Nature Communications

Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer’s Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity

(2016) Elke Prade et al.   BIOCHEMISTRY

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Polymorphism of Alzheimer’s β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study

(2016) Matthew R. Elkins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

[ 18 F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: Specific detection of advanced phases of amyloid-β pathology

(2015) Dietmar Rudolf Thal et al.   Alzheimers & Dementia

19 F Paramagnetic Relaxation Enhancement: A Valuable Tool for Distance Measurements in Proteins

(2015) Elena Matei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide

(2015) Elke Prade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau imaging: early progress and future directions

(2015) Victor L Villemagne et al.   LANCET NEUROLOGY

Amyloid Polymorphism: Structural Basis and Neurobiological Relevance

(2015) Robert Tycko   NEURON

Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation

(2014) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

19F-Labeling of Peptides Revealing Long-Range NMR Distances in Fluid Membranes

(2014) Stephan L. Grage et al.   Journal of Physical Chemistry Letters

Distinct synthetic A  prion strains producing different amyloid deposits in bigenic mice

(2014) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy

(2013) Robert Tycko et al.   ACCOUNTS OF CHEMICAL RESEARCH

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Fluorine-18 Radiolabeled Heterocycles as PET Tracers for Imaging β - Amyloid Plaques in Alzheimer’s Disease

(2013) Fanxing Zeng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Broadband homonuclear correlation spectroscopy driven by combined R2nv sequences under fast magic angle spinning for NMR structural analysis of organic and biological solids

(2013) Guangjin Hou et al.   JOURNAL OF MAGNETIC RESONANCE

Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease

(2013) Rik Vandenberghe et al.   NeuroImage-Clinical

Structural Properties of EGCG-Induced, Nontoxic Alzheimer's Disease Aβ Oligomers

(2012) Juan Miguel Lopez del Amo et al.   JOURNAL OF MOLECULAR BIOLOGY

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

The Amyloid-Congo Red Interface at Atomic Resolution

(2011) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SIMPSON: A general simulation program for solid-state NMR spectroscopy

(2011) Mads Bak et al.   JOURNAL OF MAGNETIC RESONANCE

A New Structural Model of Aβ40Fibrils

(2011) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Current applications of 19F NMR to studies of protein structure and dynamics

(2011) Julianne L. Kitevski-LeBlanc et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease

(2011) K. Broersen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ligand binding strategies of human serum albumin: How can the cargo be utilized?

(2009) Ankita Varshney et al.   CHIRALITY

Characterization of different water pools in solid-state NMR protein samples

(2009) Anja Böckmann et al.   JOURNAL OF BIOMOLECULAR NMR

Whole-Body Biodistribution and Radiation Dosimetry of 18F-GE067: A Radioligand for In Vivo Brain Amyloid Imaging

(2009) M. Koole et al.   JOURNAL OF NUCLEAR MEDICINE

Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

(2009) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA