标题
The physiological role of α‐synuclein and its relationship to Parkinson’s Disease
作者
关键词
-
出版物
JOURNAL OF NEUROCHEMISTRY
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2019-07-04
DOI
10.1111/jnc.14810
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Identification of β-synuclein on secretory granules in chromaffin cells and the effects of α- and β-synuclein on post-fusion BDNF discharge and fusion pore expansion
- (2019) Prabhodh S. Abbineni et al. NEUROSCIENCE LETTERS
- Synapsins regulate α-synuclein functions
- (2019) Merav Atias et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
- (2019) Jichao Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains
- (2018) Francesca Longhena et al. BRAIN PATHOLOGY
- Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
- (2018) Chao Peng et al. NATURE
- α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton
- (2018) Dalila G. Ordonez et al. NEURON
- C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
- (2018) Janin Lautenschläger et al. Nature Communications
- Optical detection of three modes of endocytosis at hippocampal synapses
- (2018) Natali L Chanaday et al. eLife
- Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties
- (2018) Huan Bao et al. NATURE
- Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease
- (2018) Silke Nuber et al. NEURON
- Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held
- (2017) Kohgaku Eguchi et al. JOURNAL OF NEUROSCIENCE
- T cells from patients with Parkinson’s disease recognize α-synuclein peptides
- (2017) David Sulzer et al. NATURE
- α-Synuclein promotes dilation of the exocytotic fusion pore
- (2017) Todd Logan et al. NATURE NEUROSCIENCE
- Not just amyloid: physiological functions of the amyloid precursor protein family
- (2017) Ulrike C. Müller et al. NATURE REVIEWS NEUROSCIENCE
- Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits
- (2017) Megan E. Larson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling
- (2017) Audrey T. Medeiros et al. Frontiers in Cellular Neuroscience
- DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function
- (2017) N. Plotegher et al. Scientific Reports
- Synucleins Have Multiple Effects on Presynaptic Architecture
- (2017) Karina J. Vargas et al. Cell Reports
- -Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals
- (2016) J. Xu et al. JOURNAL OF NEUROSCIENCE
- Hemi-fused structure mediates and controls fusion and fission in live cells
- (2016) Wei-Dong Zhao et al. NATURE
- Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
- (2016) Frank Soldner et al. NATURE
- Defects in trafficking bridge Parkinson's disease pathology and genetics
- (2016) Asa Abeliovich et al. NATURE
- Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane
- (2016) Peter J. Wen et al. Nature Communications
- -synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons
- (2015) M. Zaltieri et al. JOURNAL OF CELL SCIENCE
- Tau in physiology and pathology
- (2015) Yipeng Wang et al. NATURE REVIEWS NEUROSCIENCE
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
- (2015) Ulf Dettmer et al. Nature Communications
- Nonaggregated α-Synuclein Influences SNARE-Dependent Vesicle Docking via Membrane Binding
- (2014) Ying Lai et al. BIOCHEMISTRY
- BAR Domain Scaffolds in Dynamin-Mediated Membrane Fission
- (2014) Oliver Daumke et al. CELL
- α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling
- (2014) Lina Wang et al. CURRENT BIOLOGY
- -Synuclein Is Localized to Mitochondria-Associated ER Membranes
- (2014) C. Guardia-Laguarta et al. JOURNAL OF NEUROSCIENCE
- Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
- (2014) K. J. Vargas et al. JOURNAL OF NEUROSCIENCE
- Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation
- (2014) David J. Busch et al. MOLECULAR BIOLOGY OF THE CELL
- Clathrin regenerates synaptic vesicles from endosomes
- (2014) Shigeki Watanabe et al. NATURE
- α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
- (2014) Jacqueline Burré et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
- (2013) Suzanne Lesage et al. ANNALS OF NEUROLOGY
- α-Synuclein Can Inhibit SNARE-Mediated Vesicle Fusion through Direct Interactions with Lipid Bilayers
- (2013) David C. DeWitt et al. BIOCHEMISTRY
- Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra
- (2013) Pablo Garcia-Reitboeck et al. EXPERIMENTAL NEUROLOGY
- In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells
- (2013) Ulf Dettmer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mapping the Subcellular Distribution of -Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinson's Disease Pathogenesis
- (2013) D. Boassa et al. JOURNAL OF NEUROSCIENCE
- rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
- (2013) Marusela Oliveras-Salvá et al. Molecular Neurodegeneration
- A novel -synuclein missense mutation in Parkinson disease
- (2013) C. Proukakis et al. NEUROLOGY
- Transmission of multiple system atrophy prions to transgenic mice
- (2013) J. C. Watts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
- (2013) S. Janezic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Large -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
- (2013) B.-K. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
- (2013) Jiajie Diao et al. eLife
- Monomeric Synucleins Generate Membrane Curvature
- (2012) Christopher H. Westphal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer
- (2012) Bruno Fauvet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Actin coating and compression of fused secretory vesicles are essential for surfactant secretion - a role for Rho, formins and myosin II
- (2012) P. Miklavc et al. JOURNAL OF CELL SCIENCE
- Structural Intermediates during α-Synuclein Fibrillogenesis on Phospholipid Vesicles
- (2012) Gemma Comellas et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- Impaired neurotransmission caused by overexpression of -synuclein in nigral dopamine neurons
- (2012) M. Lundblad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Influence of Synaptic Vesicle Position on Release Probability and Exocytotic Fusion Mode
- (2012) H. Park et al. SCIENCE
- Perspectives on Kiss-and-Run: Role in Exocytosis, Endocytosis, and Neurotransmission
- (2011) AbdulRasheed A. Alabi et al. Annual Review of Physiology
- Folding and misfolding of alpha-synuclein on membranes
- (2011) Igor Dikiy et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Sub-regional differences and mechanisms of the short-term plasticity of dopamine overflow in striatum in mice lacking alpha-synuclein
- (2011) Heramb Chadchankar et al. BRAIN RESEARCH
- Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
- (2011) Ken Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Actomyosin II contractility expels von Willebrand factor from Weibel–Palade bodies during exocytosis
- (2011) Thomas D. Nightingale et al. JOURNAL OF CELL BIOLOGY
- α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding
- (2011) Iwona M. Pranke et al. JOURNAL OF CELL BIOLOGY
- Synuclein accumulation is associated with cell-specific neuronal death after spinal cord injury
- (2011) David J. Busch et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Molecular Basis for the Glycosphingolipid-Binding Specificity of α-Synuclein: Key Role of Tyrosine 39 in Membrane Insertion
- (2011) Jacques Fantini et al. JOURNAL OF MOLECULAR BIOLOGY
- Functional Alterations to the Nigrostriatal System in Mice Lacking All Three Members of the Synuclein Family
- (2011) S. Anwar et al. JOURNAL OF NEUROSCIENCE
- A new role for the dynamin GTPase in the regulation of fusion pore expansion
- (2011) Arun Anantharam et al. MOLECULAR BIOLOGY OF THE CELL
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Duration of fusion pore opening and the amount of hormone released are regulated by myosin II during kiss-and-run exocytosis
- (2010) Ryo Aoki et al. BIOCHEMICAL JOURNAL
- Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles
- (2010) Elizabeth R. Middleton et al. BIOPHYSICAL JOURNAL
- SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease
- (2010) Pablo Garcia-Reitböck et al. BRAIN
- Endophilin Functions as a Membrane-Bending Molecule and Is Delivered to Endocytic Zones by Exocytosis
- (2010) Jihong Bai et al. CELL
- Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
- (2010) Frits Kamp et al. EMBO JOURNAL
- Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins
- (2010) Jobin Varkey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis
- (2010) James H. Soper et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Synapsins Differentially Control Dopamine and Serotonin Release
- (2010) B. M. Kile et al. JOURNAL OF NEUROSCIENCE
- A Pathologic Cascade Leading to Synaptic Dysfunction in -Synuclein-Induced Neurodegeneration
- (2010) D. A. Scott et al. JOURNAL OF NEUROSCIENCE
- Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
- (2010) Venu M. Nemani et al. NEURON
- In Vivo Imaging of α-Synuclein in Mouse Cortex Demonstrates Stable Expression and Differential Subcellular Compartment Mobility
- (2010) Vivek K. Unni et al. PLoS One
- -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
- (2010) B. Greten-Harrison et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy
- (2009) Christina R. Bodner et al. JOURNAL OF MOLECULAR BIOLOGY
- Tryptophan Fluorescence Reveals Structural Features of α-Synuclein Oligomers
- (2009) B.D. van Rooijen et al. JOURNAL OF MOLECULAR BIOLOGY
- Differential Activity-Dependent Secretion of Brain-Derived Neurotrophic Factor from Axon and Dendrite
- (2009) N. Matsuda et al. JOURNAL OF NEUROSCIENCE
- F-Actin and Myosin II Accelerate Catecholamine Release from Chromaffin Granules
- (2009) K. Berberian et al. JOURNAL OF NEUROSCIENCE
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- Interplay of -synuclein binding and conformational switching probed by single-molecule fluorescence
- (2009) A. C. M. Ferreon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Dynamic Control of Kiss-And-Run and Vesicular Reuse Probed with Single Nanoparticles
- (2009) Q. Zhang et al. SCIENCE
- Dynamin I plays dual roles in the activity-dependent shift in exocytic mode in mouse adrenal chromaffin cells
- (2008) Tiberiu Fulop et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Phosphorylation, lipid raft interaction and traffic of α-synuclein in a yeast model for Parkinson
- (2008) Piotr Zabrocki et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Olfactory deficits in mice overexpressing human wildtype -synuclein
- (2008) Sheila M. Fleming et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein
- (2008) Steven L. Senior et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Optical Reporters for the Conformation of -Synuclein Reveal a Specific Interaction with Mitochondria
- (2008) K. Nakamura et al. JOURNAL OF NEUROSCIENCE
- Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles
- (2008) Elka R. Georgieva et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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