Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes
出版年份 2021 全文链接
标题
Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes
作者
关键词
-
出版物
Science Advances
Volume 7, Issue 20, Pages eabg2174
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2021-05-15
DOI
10.1126/sciadv.abg2174
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure
- (2020) David R. Boyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures of α-synuclein filaments from multiple system atrophy
- (2020) Manuel Schweighauser et al. NATURE
- Deep mutational scanning reveals the structural basis for α-synuclein activity
- (2020) Robert W. Newberry et al. Nature Chemical Biology
- A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function
- (2020) Ciaran P. A. Doherty et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Correcting for magnetic field drift in magic-angle spinning NMR datasets
- (2019) Eszter E. Najbauer et al. JOURNAL OF MAGNETIC RESONANCE
- The physiological role of α‐synuclein and its relationship to Parkinson’s Disease
- (2019) David Sulzer et al. JOURNAL OF NEUROCHEMISTRY
- Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
- (2019) Sarah H. Shahmoradian et al. NATURE NEUROSCIENCE
- Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
- (2019) Ricardo Guerrero-Ferreira et al. eLife
- Local and Global Dynamics in Intrinsically Disordered Synuclein
- (2018) Nasrollah Rezaei-Ghaleh et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Investigation of α-Synuclein Amyloid Fibrils Using the Fluorescent Probe Thioflavin T
- (2018) Anna Sulatskaya et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Determination of Long-Range Distances by Fast Magic-Angle-Spinning Radiofrequency-Driven 19F–19F Dipolar Recoupling NMR
- (2018) Matthias Roos et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
- (2018) Binsen Li et al. Nature Communications
- Disruptive membrane interactions of alpha-synuclein aggregates
- (2018) Aditya Iyer et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-β Fibrils
- (2017) Francesca Peccati et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Amyloid Fibril Polymorphism: Almost Identical on the Atomic Level, Mesoscopically Very Different
- (2017) Carolin Seuring et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
- (2017) Giuliana Fusco et al. SCIENCE
- Distinct Mechanisms Determine α-Synuclein Fibril Morphology during Growth and Maturation
- (2016) Arshdeep Sidhu et al. ACS Chemical Neuroscience
- Mode of Ezrin-Membrane Interaction as a Function of PIP 2 Binding and Pseudophosphorylation
- (2016) Victoria Shabardina et al. BIOPHYSICAL JOURNAL
- Molecular mechanisms of protein aggregation from global fitting of kinetic models
- (2016) Georg Meisl et al. Nature Protocols
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
- (2016) Céline Galvagnion et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis of synaptic vesicle assembly promoted by α-synuclein
- (2016) Giuliana Fusco et al. Nature Communications
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
- (2015) Céline Galvagnion et al. Nature Chemical Biology
- Multiple-System Atrophy
- (2015) Alessandra Fanciulli et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
- (2015) Serene W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy
- (2014) Woonghee Lee et al. BIOINFORMATICS
- Experimental Determination of the Electrostatic Nature of Carbonyl Hydrogen-Bonding Interactions Using IR-NMR Correlations
- (2014) Somnath M. Kashid et al. Journal of Physical Chemistry Letters
- The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation
- (2014) Nikolai Lorenzen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Rapid Proton-Detected NMR Assignment for Proteins with Fast Magic Angle Spinning
- (2014) Emeline Barbet-Massin et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Biophysical groundwork as a hinge to unravel the biology of α-synuclein aggregation and toxicity
- (2014) Nicoletta Plotegher et al. QUARTERLY REVIEWS OF BIOPHYSICS
- Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour
- (2014) Giuliana Fusco et al. Nature Communications
- Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation
- (2014) Luis Fonseca-Ornelas et al. Nature Communications
- Yet another polymorph of α-synuclein: solid-state sequential assignments
- (2013) Julia Gath et al. Biomolecular NMR Assignments
- Identification of Fibril-Like Tertiary Contacts in Soluble Monomeric α-Synuclein
- (2013) Santiago Esteban-Martín et al. BIOPHYSICAL JOURNAL
- Surface behavior of α-Synuclein and its interaction with phospholipids using the Langmuir monolayer technique: A comparison between monomeric and fibrillar α-Synuclein
- (2013) Ali Chaari et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure
- (2012) María Soledad Celej et al. BIOCHEMICAL JOURNAL
- Structural Intermediates during α-Synuclein Fibrillogenesis on Phospholipid Vesicles
- (2012) Gemma Comellas et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Mechanism of Membrane Interaction and Disruption by α-Synuclein
- (2011) Nicholas P. Reynolds et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts
- (2009) Yang Shen et al. JOURNAL OF BIOMOLECULAR NMR
- Characterization of different water pools in solid-state NMR protein samples
- (2009) Anja Böckmann et al. JOURNAL OF BIOMOLECULAR NMR
- The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast
- (2009) Katherina Vamvaca et al. JOURNAL OF MOLECULAR BIOLOGY
- Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy
- (2009) Christina R. Bodner et al. JOURNAL OF MOLECULAR BIOLOGY
- Spin-Label EPR on α-Synuclein Reveals Differences in the Membrane Binding Affinity of the Two Antiparallel Helices
- (2008) Malte Drescher et al. CHEMBIOCHEM
- Structure of membrane-bound -synuclein from site-directed spin labeling and computational refinement
- (2008) C. C. Jao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started