Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
出版年份 2018 全文链接
标题
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume -, Issue -, Pages 201804198
出版商
Proceedings of the National Academy of Sciences
发表日期
2018-09-25
DOI
10.1073/pnas.1804198115
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity
- (2018) Hanna Kim et al. MOLECULAR NEUROBIOLOGY
- High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors
- (2017) Jordi Pujols et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
- (2017) Michele Perni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
- (2016) Marija Iljina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease
- (2016) Lars Tatenhorst et al. Acta Neuropathologica Communications
- The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities
- (2015) Samuel Genheden et al. Expert Opinion on Drug Discovery
- Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells
- (2015) Ben Moree et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkinson's disease
- (2015) Lorraine V Kalia et al. LANCET
- Multiple-System Atrophy
- (2015) Alessandra Fanciulli et al. NEW ENGLAND JOURNAL OF MEDICINE
- Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein
- (2015) Nuzhat Ahsan et al. Scientific Reports
- Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)
- (2014) Maria Eugenia Herva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
- (2014) Diana F. Lázaro et al. PLoS Genetics
- Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
- (2013) Jens Wagner et al. ACTA NEUROPATHOLOGICA
- The Function of α-Synuclein
- (2013) Jacob T. Bendor et al. NEURON
- PELE web server: atomistic study of biomolecular systems at your fingertips
- (2013) Armin Madadkar-Sobhani et al. NUCLEIC ACIDS RESEARCH
- Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis elegans and Mammalian Models of Parkinson's Disease
- (2012) A. J. Harrington et al. JOURNAL OF NEUROSCIENCE
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
- (2011) Lisa Fellner et al. ACTA NEUROPATHOLOGICA
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Revealing Noncovalent Interactions
- (2010) Erin R. Johnson et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway
- (2010) S. Abbas et al. PHYTOMEDICINE
- EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
- (2010) Jan Bieschke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity
- (2009) Tali Gidalevitz et al. PLoS Genetics
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
- (2008) Dagmar E Ehrnhoefer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model
- (2008) S. Hamamichi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging
- (2008) Tjakko J. van Ham et al. PLoS Genetics
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