Bazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence

BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-κB pathways in aging mice induced by D-galactose and NaNO2

(2021) Lin Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

(2021) Hana Štorkánová et al.   Scientific Reports

Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability

(2021) Taimoor I. Sheikh et al.   Translational Psychiatry

Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration

(2021) Qian Lei et al.   Science Translational Medicine

Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment

(2021) Sareer Ahmad et al.   Frontiers in Pharmacology

MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease

(2021) Charis Ringland et al.   BMC NEUROSCIENCE

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

(2021) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular senescence at the crossroads of inflammation and Alzheimer's disease

(2021) Ana Guerrero et al.   TRENDS IN NEUROSCIENCES

Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses

(2021) Grzegorz Wiera et al.   Cells

BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice

(2021) Lin Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Corrigendum: Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects

(2021) Dan Huang et al.   Frontiers in Pharmacology

Roles of Crosstalk between Astrocytes and Microglia in Triggering Neuroinflammation and Brain Edema Formation in 1,2-Dichloroethane-Intoxicated Mice

(2021) Jinhan Yang et al.   Cells

Synaptic Plasticity Forms and Functions

(2020) Jeffrey C. Magee et al.   Annual Review of Neuroscience

Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

(2020) Kaiyue Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis

(2020) Hugo Charles-Messance et al.   Journal of Neuroinflammation

Chinese medicine Bazi Bushen capsule improves lipid metabolism in ovariectomized female ApoE−/− mice

(2020) Dan Huang et al.   Annals of Palliative Medicine

Cellular senescence and Alzheimer disease: the egg and the chicken scenario

(2020) Sara Saez-Atienzar et al.   NATURE REVIEWS NEUROSCIENCE

Plant-Derived Antioxidants Protect the Nervous System From Aging by Inhibiting Oxidative Stress

(2020) Xiaoji Cui et al.   Frontiers in Aging Neuroscience

Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1 −/− mice

(2020) Edward Fielder et al.   AGING CELL

Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition

(2020) Wei-Na Jin et al.   NATURE NEUROSCIENCE

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Schisandrin ameliorates cognitive impairment and attenuates Aβ deposition in APP/PS1 transgenic mice: involvement of adjusting neurotransmitters and their metabolite changes in the brain

(2018) Bin-bin Wei et al.   ACTA PHARMACOLOGICA SINICA

Custom-Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia

(2018) Feng Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury

(2018) Yuhui Yan et al.   BRAIN BEHAVIOR AND IMMUNITY

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

(2018) Mark P. Mattson et al.   Cell Metabolism

Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration

(2018) Sandeep Singh et al.   LIFE SCIENCES

Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

(2018) Devesh Tewari et al.   Frontiers in Aging Neuroscience

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in Mice via Inhibition of Cellular Senescence and Oxidative Stress

(2018) Kaiyue Sun et al.   Oxidative Medicine and Cellular Longevity

Regulation of extrasynaptic signaling by polysialylated NCAM: Impact for synaptic plasticity and cognitive functions

(2017) Hristo Varbanov et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

(2017) Lilach Soreq et al.   Cell Reports

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway

(2016) Jin Gao et al.   METABOLIC BRAIN DISEASE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

A cortical–hippocampal–cortical loop of information processing during memory consolidation

(2016) Gideon Rothschild et al.   NATURE NEUROSCIENCE

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Apoptosis-related proteins and proliferation markers in the orbitofrontal cortex in major depressive disorder

(2014) Jose J. Miguel-Hidalgo et al.   JOURNAL OF AFFECTIVE DISORDERS

Hypomorphic PCNA mutation underlies a human DNA repair disorder

(2014) Emma L. Baple et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging and motor inhibition: A converging perspective provided by brain stimulation and imaging approaches

(2014) Oron Levin et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

PCNA: a silent housekeeper or a potential therapeutic target?

(2014) Shao-Chun Wang   TRENDS IN PHARMACOLOGICAL SCIENCES

Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems

(2012) Wolfgang Kaufmann et al.   TOXICOLOGIC PATHOLOGY

Characterizing cognitive aging in humans with links to animal models

(2012) Gene E. Alexander et al.   Frontiers in Aging Neuroscience

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE