Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation

(2020) Valentina C. Sladky et al.   CELL DEATH AND DIFFERENTIATION

Molecular neuroanatomy of anorexia nervosa

(2020) Derek Howard et al.   Scientific Reports

Phenotypic spectrum associated with a CRADD founder variant underlying frontotemporal predominant pachygyria in the Finnish population

(2019) Daniel L. Polla et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

(2019) Zhi-Xiang Xu et al.   Nature Communications

Exploring genetic variation that influences brain methylation in attention-deficit/hyperactivity disorder

(2019) Laura Pineda-Cirera et al.   Translational Psychiatry

Analysis of 17 genes detects mutations in 81% of 811 patients with lissencephaly

(2018) Nataliya Di Donato et al.   GENETICS IN MEDICINE

Genetics of intellectual disability in consanguineous families

(2018) Hao Hu et al.   MOLECULAR PSYCHIATRY

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

RAIDD mutations underlie the pathogenesis of thin lissencephaly (TLIS)

(2018) Hyun Ji Ha et al.   PLoS One

Spatiotemporal transcriptomic divergence across human and macaque brain development

(2018) Ying Zhu et al.   SCIENCE

The PIDDosome activates p53 in response to supernumerary centrosomes

(2017) Luca L. Fava et al.   GENES & DEVELOPMENT

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

(2017) Kiyohiro Ando et al.   JOURNAL OF CELL BIOLOGY

The resurrection of the PIDDosome – emerging roles in the DNA-damage response and centrosome surveillance

(2017) Valentina Sladky et al.   JOURNAL OF CELL SCIENCE

Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families

(2017) R Harripaul et al.   MOLECULAR PSYCHIATRY

Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant

(2016) Nataliya Di Donato et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery

(2016) Eric M Scott et al.   NATURE GENETICS

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

PIDD mediates and stabilizes the interaction between RAIDD and Caspase-2 for the PIDDosome assembly

(2013) Tae-Ho Jang et al.   BMB Reports

Caspase-2 at a glance

(2013) L. L. Fava et al.   JOURNAL OF CELL SCIENCE

Neuronal caspase 2 activity and function requires RAIDD, but not PIDD

(2012) Elena M. Ribe et al.   BIOCHEMICAL JOURNAL

Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage

(2012) F J Bock et al.   CELL DEATH AND DIFFERENTIATION

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

Genetic Mapping and Exome Sequencing Identify Variants Associated with Five Novel Diseases

(2012) Erik G. Puffenberger et al.   PLoS One

In vitro reconstitution of the interactions in the PIDDosome

(2010) Tae-ho Jang et al.   APOPTOSIS

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY

Prodynorphin-Derived Peptides Are Critical Modulators of Anxiety and Regulate Neurochemistry and Corticosterone

(2008) Walter Wittmann et al.   NEUROPSYCHOPHARMACOLOGY