Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1 −/− mice

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

(2019) Rhys Anderson et al.   EMBO JOURNAL

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence

(2019) Mikolaj Ogrodnik et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction

(2019) Vladimir V. Senatorov et al.   Science Translational Medicine

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Association of Peripheral Interleukin-6 with Global Cognitive Decline in Non-demented Adults: A Meta-Analysis of Prospective Studies

(2018) Steven Bradburn et al.   Frontiers in Aging Neuroscience

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice

(2018) Clara Correia-Melo et al.   AGING CELL

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

(2017) Edward Fielder et al.   JOURNAL OF ALZHEIMERS DISEASE

The effects of aging in the hippocampus and cognitive decline

(2017) Luis E.B. Bettio et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Robust, universal biomarker assay to detect senescent cells in biological specimens

(2016) Konstantinos Evangelou et al.   AGING CELL

p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration

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DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

(2015) Jodie Birch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Non-Steroidal Anti-Inflammatory Drugs as a Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Treatment Effect

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Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression

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Neuroinflammation in the normal aging hippocampus

(2015) R.M. Barrientos et al.   NEUROSCIENCE

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma

(2015) C. L. Wilson et al.   Nature Communications

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

Feedforward Inhibition Underlies the Propagation of Cholinergically Induced Gamma Oscillations from Hippocampal CA3 to CA1

(2013) R. Zemankovics et al.   JOURNAL OF NEUROSCIENCE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Multiple origins of the cortical gamma rhythm

(2010) Miles A. Whittington et al.   Developmental Neurobiology

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Impaired Adult Neurogenesis Associated with Short-Term Memory Defects in NF- B p50-Deficient Mice

(2008) S. Denis-Donini et al.   JOURNAL OF NEUROSCIENCE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Nuclear factor-κB1: Regulation and function

(2007) Silvia Gaspar Pereira et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY