Enzymatic Nitrogen Insertion into Unactivated C–H Bonds

C–N Bond Forming Radical Rebound Is the Enantioselectivity-Determining Step in P411-Catalyzed Enantioselective C(sp3)–H Amination: A Combined Computational and Experimental Investigation

(2022) Binh Khanh Mai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A kinase-cGAS cascade to synthesize a therapeutic STING activator

(2022) John A. McIntosh et al.   NATURE

Non-Native Anionic Ligand Binding and Reactivity in Engineered Variants of the Fe(II)- and α-Ketoglutarate-Dependent Oxygenase, SadA

(2022) Natalie H. Chan et al.   INORGANIC CHEMISTRY

Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer

(2021) Yang Yang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cobalt-Catalyzed Intermolecular C–H Amidation of Unactivated Alkanes

(2021) Jeonghyo Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocatalytic, Intermolecular C‐H Bond Functionalization for the Synthesis of Enantioenriched Amides

(2021) Soumitra Athavale et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes

(2021) Zhen Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines

(2020) Aaron Trowbridge et al.   CHEMICAL REVIEWS

Bidentate Directing Groups: An Efficient Tool in C–H Bond Functionalization Chemistry for the Expedient Construction of C–C Bonds

(2020) Supriya Rej et al.   CHEMICAL REVIEWS

Enzymatic Primary Amination of Benzylic and Allylic C(sp3)–H Bonds

(2020) Zhi-Jun Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition Metal‐Catalyzed Enantioselective C–H Functionalization via Chiral Transient Directing Group Strategy

(2020) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dirhodium tetracarboxylates as catalysts for selective intermolecular C–H functionalization

(2019) Huw M. L. Davies et al.   Nature Reviews Chemistry

Photocatalytic regio- and stereoselective C(sp3)–H functionalization of benzylic and allylic hydrocarbons as well as unactivated alkanes

(2019) Yanjun Li et al.   Nature Catalysis

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

(2019) Mark A. Huffman et al.   SCIENCE

Unprecedented Cyclization Catalyzed by a Cytochrome P450 in Benzastatin Biosynthesis

(2018) Hayama Tsutsumi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism

(2018) Anja Greule et al.   NATURAL PRODUCT REPORTS

A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

(2018) Carlo Sambiagio et al.   CHEMICAL SOCIETY REVIEWS

Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization

(2018) Ruijie K. Zhang et al.   NATURE

Desymmetrization of cyclohexanes by site- and stereoselective C–H functionalization

(2018) Jiantao Fu et al.   NATURE

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

(2017) Michele Tavanti et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Direct Catalytic Synthesis of Unprotected 2-Amino-1-Phenylethanols from Alkenes by Using Iron(II) Phthalocyanine

(2016) Luca Legnani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-selective and stereoselective functionalization of unactivated C–H bonds

(2016) Kuangbiao Liao et al.   NATURE

Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis

(2016) Shuke Wu et al.   Nature Communications

Direct and Practical Synthesis of Primary Anilines through Iron-Catalyzed C–H Bond Amination

(2016) Luca Legnani et al.   ACS Catalysis

Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities

(2016) John F. Hartwig et al.   ACS Central Science

Metal-catalysed azidation of tertiary C–H bonds suitable for late-stage functionalization

(2015) Ankit Sharma et al.   NATURE

Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups

(2015) Zhengkai Chen et al.   Organic Chemistry Frontiers

Copper-Catalyzed Intermolecular Amidation and Imidation of Unactivated Alkanes

(2014) Ba L. Tran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

(2014) Megan L Matthews et al.   Nature Chemical Biology

Direct Terminal Alkylamino-FunctionalizationviaMultistep Biocatalysis in One Recombinant Whole-Cell Catalyst

(2013) Manfred Schrewe et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo

(2013) John A. McIntosh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intermolecular Ritter-Type C–H Amination of Unactivated sp3 Carbons

(2012) Quentin Michaudel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes

(2009) Paul R. Ortiz de Montellano   CHEMICAL REVIEWS

Kemp elimination catalysts by computational enzyme design

(2008) Daniela Röthlisberger et al.   NATURE