Mechanisms of joint destruction in rheumatoid arthritis — immune cell–fibroblast–bone interactions
出版年份 2022 全文链接
标题
Mechanisms of joint destruction in rheumatoid arthritis — immune cell–fibroblast–bone interactions
作者
关键词
-
出版物
Nature Reviews Rheumatology
Volume 18, Issue 7, Pages 415-429
出版商
Springer Science and Business Media LLC
发表日期
2022-06-15
DOI
10.1038/s41584-022-00793-5
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Filgotinib versus placebo or adalimumab in patients with rheumatoid arthritis and inadequate response to methotrexate: a phase III randomised clinical trial
- (2021) Bernard Combe et al. ANNALS OF THE RHEUMATIC DISEASES
- JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib
- (2021) Paqui G Traves et al. ANNALS OF THE RHEUMATIC DISEASES
- Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases
- (2021) Mineto Ota et al. CELL
- The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts
- (2021) Jasna Friščić et al. IMMUNITY
- Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis
- (2021) Noriko Komatsu et al. JOURNAL OF CLINICAL INVESTIGATION
- Managing Osteoporosis and Joint Damage in Patients with Rheumatoid Arthritis: An Overview
- (2021) Yoshiya Tanaka Journal of Clinical Medicine
- Targeting of fibroblast activation protein in rheumatoid arthritis patients: imaging and ex vivo photodynamic therapy
- (2021) Daphne N Dorst et al. RHEUMATOLOGY
- Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis
- (2021) Xunyao Wu et al. Nature Communications
- Arthritis flares mediated by tissue-resident memory T cells in the joint
- (2021) Margaret H. Chang et al. Cell Reports
- JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function
- (2020) Susanne Adam et al. Science Translational Medicine
- Notch signalling drives synovial fibroblast identity and arthritis pathology
- (2020) Kevin Wei et al. NATURE
- Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes
- (2020) Gyrid Nygaard et al. Nature Reviews Rheumatology
- Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
- (2020) Stefano Alivernini et al. NATURE MEDICINE
- RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares
- (2020) Dana E. Orange et al. NEW ENGLAND JOURNAL OF MEDICINE
- OPG Production Matters Where It Happened
- (2020) Masayuki Tsukasaki et al. Cell Reports
- Efficacy and Safety of E6011, an Anti‐Fractalkine Monoclonal Antibody, in Active Rheumatoid Arthritis Patients with Inadequate Response to Methotrexate: Results of a Randomized, Double‐blind, Placebo‐controlled Phase 2 study
- (2020) Yoshiya Tanaka et al. Arthritis & Rheumatology
- Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis
- (2019) Xiaojuan He et al. EBioMedicine
- Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
- (2019) Song Ho Chang et al. Nature Communications
- IL-6 exhibits both cis and trans signaling in osteocytes and osteoblasts, but only trans signaling promotes bone formation and osteoclastogenesis
- (2019) Narelle E. McGregor et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying antirheumatic drugs (DESIRABLE study): a randomised, double-blind, placebo-controlled phase 3 trial
- (2019) Tsutomu Takeuchi et al. ANNALS OF THE RHEUMATIC DISEASES
- Distinct fibroblast subsets drive inflammation and damage in arthritis
- (2019) Adam P. Croft et al. NATURE
- Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
- (2019) Fan Zhang et al. NATURE IMMUNOLOGY
- HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness
- (2019) David Kuo et al. Science Translational Medicine
- Efficacy and safety of bimekizumab as add-on therapy for rheumatoid arthritis in patients with inadequate response to certolizumab pegol: a proof-of-concept study
- (2019) Sophie Glatt et al. ANNALS OF THE RHEUMATIC DISEASES
- Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle
- (2019) Shivana M. Lightman et al. Frontiers in Immunology
- Locally renewing resident synovial macrophages provide a protective barrier for the joint
- (2019) Stephan Culemann et al. NATURE
- Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity
- (2019) T. Miyazaki et al. Science Advances
- Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1
- (2019) Tetsuo Hasegawa et al. NATURE IMMUNOLOGY
- Plasma Cells, the Next Generation: Beyond Antibody Secretion
- (2019) Peter D. Pioli Frontiers in Immunology
- Osteoporosis in Rheumatic Diseases: Anti-rheumatic Drugs and the Skeleton
- (2018) Alanna M. Dubrovsky et al. CALCIFIED TISSUE INTERNATIONAL
- Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis
- (2018) Keiji Hirota et al. IMMUNITY
- The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
- (2018) Marietta Armaka et al. Nature Communications
- Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
- (2018) Fumitaka Mizoguchi et al. Nature Communications
- Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis
- (2018) Emmanuel Karouzakis et al. Scientific Reports
- Early sclerostin expression explains bone formation inhibition before arthritis onset in the rat adjuvant-induced arthritis model
- (2018) Guillaume Courbon et al. Scientific Reports
- Effects of the IL-23–IL-17 pathway on bone in spondyloarthritis
- (2018) Ellen M. Gravallese et al. Nature Reviews Rheumatology
- The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression
- (2018) Abdul Malik Tyagi et al. IMMUNITY
- Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis
- (2018) Isabelle Cambré et al. Nature Communications
- B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
- (2018) Wen Sun et al. Nature Communications
- Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators
- (2017) Hung N. Nguyen et al. IMMUNITY
- Matrix Metalloproteinase Gene Activation Resulting from Disordred Epigenetic Mechanisms in Rheumatoid Arthritis
- (2017) Yasuto Araki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Periarticular Bone Loss in Arthritis Is Induced by Autoantibodies Against Citrullinated Vimentin
- (2017) Cecilia Engdahl et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
- (2017) Deepak A. Rao et al. NATURE
- Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells
- (2017) Simon Rauber et al. NATURE MEDICINE
- Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases
- (2017) John A. Hamilton et al. NATURE REVIEWS DRUG DISCOVERY
- Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems
- (2017) Kazuo Okamoto et al. PHYSIOLOGICAL REVIEWS
- A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro
- (2017) Kohei Murakami et al. PLoS One
- Adenovirus-mediated delivery of Sema3A alleviates rheumatoid arthritis in a serum-transfer induced mouse model
- (2017) Yue Teng et al. Oncotarget
- Secukinumab in Active Rheumatoid Arthritis: A Phase III Randomized, Double-Blind, Active Comparator- and Placebo-Controlled Study
- (2017) Francisco J. Blanco et al. Arthritis & Rheumatology
- Early Changes of the Cortical Micro-Channel System in the Bare Area of the Joints of Patients With Rheumatoid Arthritis
- (2017) David Werner et al. Arthritis & Rheumatology
- GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness
- (2016) E.-J. Han et al. JOURNAL OF RHEUMATOLOGY
- Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease
- (2016) René Pfeifle et al. NATURE IMMUNOLOGY
- Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation
- (2016) MM Matzelle et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction
- (2016) Corinna Wehmeyer et al. Science Translational Medicine
- IL-17-producing γδ T cells enhance bone regeneration
- (2016) Takehito Ono et al. Nature Communications
- Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis
- (2016) Nida Meednu et al. Arthritis & Rheumatology
- Hypoxia-Inducible Factor (HIF) as a Target for Novel Therapies in Rheumatoid Arthritis
- (2016) Susan Hua et al. Frontiers in Pharmacology
- Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis
- (2015) Kyoung-Woon Kim et al. AMERICAN JOURNAL OF PATHOLOGY
- Effect of denosumab on Japanese patients with rheumatoid arthritis: a dose–response study of AMG 162 (Denosumab) in patients withRheumatoId arthritis on methotrexate toValidate inhibitory effect on boneErosion (DRIVE)—a 12-month, multicentre, randomised, double-blind, placebo-controlled, phase II clinical trial
- (2015) Tsutomu Takeuchi et al. ANNALS OF THE RHEUMATIC DISEASES
- RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation
- (2015) Lynett Danks et al. ANNALS OF THE RHEUMATIC DISEASES
- Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss
- (2015) Akilan Krishnamurthy et al. ANNALS OF THE RHEUMATIC DISEASES
- Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings
- (2015) Thomas Pap et al. Nature Reviews Rheumatology
- Peripheral blood CD4+CD25+CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response
- (2015) Jun Kikuchi et al. ARTHRITIS RESEARCH & THERAPY
- Immune complexes regulate bone metabolism through FcRγ signalling
- (2015) Takako Negishi-Koga et al. Nature Communications
- Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss
- (2015) Ulrike Harre et al. Nature Communications
- Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications
- (2015) Yuji Yoshida et al. Arthritis & Rheumatology
- NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB
- (2014) Hengwei Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway
- (2014) A. Bozec et al. Science Translational Medicine
- CTLA-4Ig-Induced T Cell Anergy Promotes Wnt-10b Production and Bone Formation in a Mouse Model
- (2014) Susanne Roser-Page et al. Arthritis & Rheumatology
- Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies
- (2013) Arnd Kleyer et al. ANNALS OF THE RHEUMATIC DISEASES
- The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells
- (2013) Satoshi Kubo et al. ANNALS OF THE RHEUMATIC DISEASES
- Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis
- (2013) Xiao-Xiang Chen et al. ANNALS OF THE RHEUMATIC DISEASES
- Decreased Semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis
- (2013) Shu Takagawa et al. BMC MUSCULOSKELETAL DISORDERS
- Genetics of rheumatoid arthritis contributes to biology and drug discovery
- (2013) Yukinori Okada et al. NATURE
- Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
- (2013) Noriko Komatsu et al. NATURE MEDICINE
- Effect of sclerostin-neutralising antibody on periarticular and systemic bone in a murine model of rheumatoid arthritis: a microCT study
- (2013) Massimo Marenzana et al. ARTHRITIS RESEARCH & THERAPY
- Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis
- (2012) Diederik P C de Rooy et al. ANNALS OF THE RHEUMATIC DISEASES
- Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
- (2012) Ulrike Harre et al. JOURNAL OF CLINICAL INVESTIGATION
- Osteoprotection by semaphorin 3A
- (2012) Mikihito Hayashi et al. NATURE
- IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells
- (2012) Jonathan P Sherlock et al. NATURE MEDICINE
- Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal Cells in Joints
- (2012) Noriko Komatsu et al. Frontiers in Immunology
- A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells
- (2011) M. Bombardieri et al. ANNALS OF THE RHEUMATIC DISEASES
- CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis
- (2011) Teresina Laragione et al. ARTHRITIS AND RHEUMATISM
- Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway
- (2011) Melissa M. Matzelle et al. ARTHRITIS AND RHEUMATISM
- The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-γ and interleukin-17 production by human CD4+ T cells
- (2011) Keisuke Maeshima et al. ARTHRITIS AND RHEUMATISM
- A phase II, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of MDX-1100, a fully human anti-CXCL10 monoclonal antibody, in combination with methotrexate in patients with rheumatoid arthritis
- (2011) Michael Yellin et al. ARTHRITIS AND RHEUMATISM
- IL-17 increases cadherin-11 expression in a model of autoimmune experimental arthritis and in rheumatoid arthritis
- (2011) Young-Eun Park et al. IMMUNOLOGY LETTERS
- Matrix-embedded cells control osteoclast formation
- (2011) Jinhu Xiong et al. NATURE MEDICINE
- Evidence for osteocyte regulation of bone homeostasis through RANKL expression
- (2011) Tomoki Nakashima et al. NATURE MEDICINE
- Suppression of bone formation by osteoclastic expression of semaphorin 4D
- (2011) Takako Negishi-Koga et al. NATURE MEDICINE
- The Pathogenesis of Rheumatoid Arthritis
- (2011) Iain B. McInnes et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cadherin-11 regulates fibroblast inflammation
- (2011) S. K. Chang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation
- (2010) Mario M. Zaiss et al. ARTHRITIS AND RHEUMATISM
- Interleukin-1β is a potent inhibitor of bone formation in vitro
- (2010) Philip Stashenko et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis
- (2010) M. M. Zaiss et al. JOURNAL OF IMMUNOLOGY
- A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
- (2010) Yuta Kochi et al. NATURE GENETICS
- Periarticular bone changes in rheumatoid arthritis: pathophysiological implications and clinical utility
- (2009) S. R Goldring ANNALS OF THE RHEUMATIC DISEASES
- Osteoblast Function Is Compromised at Sites of Focal Bone Erosion in Inflammatory Arthritis
- (2009) Nicole C Walsh et al. JOURNAL OF BONE AND MINERAL RESEARCH
- CTLA-4 directly inhibits osteoclast formation
- (2008) R Axmann et al. ANNALS OF THE RHEUMATIC DISEASES
- Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial
- (2008) Stanley B. Cohen et al. ARTHRITIS AND RHEUMATISM
- An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis
- (2008) A. K. Brown et al. ARTHRITIS AND RHEUMATISM
- Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis
- (2008) Sonja Herman et al. ARTHRITIS AND RHEUMATISM
- Regulatory T Cells and Immune Tolerance
- (2008) Shimon Sakaguchi et al. CELL
- Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction
- (2008) Hideki Ogura et al. IMMUNITY
- Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases
- (2008) Maria Armaka et al. JOURNAL OF EXPERIMENTAL MEDICINE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search