Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction

A Randomized, Double-Blind Phase 2 Clinical Trial of Blosozumab, a Sclerostin Antibody, in Postmenopausal Women with Low Bone Mineral Density

(2015) Robert R. Recker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

(2015) Wafa Bouaziz et al.   ARTHRITIS RESEARCH & THERAPY

Effect of sclerostin antibody treatment in a mouse model of severe osteogenesis imperfecta

(2014) Andreas Roschger et al.   BONE

Progressive Increases in Bone Mass and Bone Strength in an Ovariectomized Rat Model of Osteoporosis After 26 Weeks of Treatment With a Sclerostin Antibody

(2014) Xiaodong Li et al.   ENDOCRINOLOGY

TNF-α Upregulates Sclerostin Expression in Obese Mice Fed a High-Fat Diet

(2014) Kyunghwa Baek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Romosozumab in Postmenopausal Women with Low Bone Mineral Density

(2014) Michael R. McClung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis

(2013) Xiao-Xiang Chen et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling

(2013) Maarten van Dinther et al.   PLoS One

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1

(2013) Shuyu Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of sclerostin-neutralising antibody on periarticular and systemic bone in a murine model of rheumatoid arthritis: a microCT study

(2013) Massimo Marenzana et al.   ARTHRITIS RESEARCH & THERAPY

Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury

(2012) Martine Roudier et al.   ARTHRITIS AND RHEUMATISM

TNF-α mediates the stimulation of sclerostin expression in an estrogen-deficient condition

(2012) Beom-Jun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis

(2010) O. Frey et al.   ANNALS OF THE RHEUMATIC DISEASES

Mitogen-Activated Protein Kinases Promote WNT/ -Catenin Signaling via Phosphorylation of LRP6

(2010) I. Cervenka et al.   MOLECULAR AND CELLULAR BIOLOGY

Pro-Inflammatory Cytokines TNF-Related Weak Inducer of Apoptosis (TWEAK) and TNFα Induce the Mitogen-Activated Protein Kinase (MAPK)-Dependent Expression of Sclerostin in Human Osteoblasts*

(2009) Cristina Vincent et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Parathyroid hormone (PTH)–induced bone gain is blunted in SOST overexpressing and deficient mice

(2009) Ina Kramer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis

(2008) Isao Matsumoto et al.   ARTHRITIS RESEARCH & THERAPY