The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

(2020) Trinidad Montero-Melendez et al.   Nature Communications

Advances in understanding molecular regulation of innate immune memory

(2020) Jorge Domínguez-Andrés et al.   CURRENT OPINION IN CELL BIOLOGY

Complement and human T cell metabolism: Location, location, location

(2020) Erin E. West et al.   IMMUNOLOGICAL REVIEWS

Notch signalling drives synovial fibroblast identity and arthritis pathology

(2020) Kevin Wei et al.   NATURE

Characterizing the original anti‐C5 function‐blocking antibody, BB5.1, for species specificity, mode of action and interactions with C5

(2020) Wioleta M. Zelek et al.   IMMUNOLOGY

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

(2020) Stefano Alivernini et al.   NATURE MEDICINE

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops

(2019) Isabelle Cambré et al.   ANNALS OF THE RHEUMATIC DISEASES

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Determining cell type abundance and expression from bulk tissues with digital cytometry

(2019) Aaron M. Newman et al.   NATURE BIOTECHNOLOGY

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Clinical promise of next-generation complement therapeutics

(2019) Dimitrios C. Mastellos et al.   NATURE REVIEWS DRUG DISCOVERY

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer

(2018) Nicholas S. Akins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Physiological effects of modulating the interleukin-6 axis

(2018) Georg Schett   RHEUMATOLOGY

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

(2018) Fumitaka Mizoguchi et al.   Nature Communications

Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis

(2018) Jane Falconer et al.   Arthritis & Rheumatology

Complement in the Initiation and Evolution of Rheumatoid Arthritis

(2018) V. Michael Holers et al.   Frontiers in Immunology

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

(2018) Martin Böttcher et al.   OncoImmunology

Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis

(2018) Marta F Bustamante et al.   ANNALS OF THE RHEUMATIC DISEASES

A model of chronic enthesitis and new bone formation characterized by multimodal imaging

(2018) Christine Czegley et al.   Disease Models & Mechanisms

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

(2018) Georg Schett et al.   Nature Communications

Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation

(2018) Ben C. King et al.   Cell Metabolism

Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis

(2018) Isabelle Cambré et al.   Nature Communications

Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators

(2017) Hung N. Nguyen et al.   IMMUNITY

The epigenetic architecture at gene promoters determines cell type-specific LPS tolerance

(2017) Kerstin Klein et al.   JOURNAL OF AUTOIMMUNITY

Novel insights into the expression pattern of anaphylatoxin receptors in mice and men

(2017) Yves Laumonnier et al.   MOLECULAR IMMUNOLOGY

The complement system as a potential therapeutic target in rheumatic disease

(2017) Leendert A. Trouw et al.   Nature Reviews Rheumatology

Epigenetics in the pathogenesis of RA

(2017) Caroline Ospelt et al.   Seminars in Immunopathology

C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis

(2017) Hanif J. Khameneh et al.   Frontiers in Pharmacology

Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis

(2017) Trudy McGarry et al.   Scientific Reports

Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions

(2017) Manuel J. Del Rey et al.   Scientific Reports

Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions

(2016) Georg Schett et al.   ANNALS OF THE RHEUMATIC DISEASES

A novel “complement-metabolism-inflammasome axis” as a key regulator of immune cell effector function

(2016) Giuseppina Arbore et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular mechanisms of innate memory and tolerance to LPS

(2016) John J. Seeley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

(2016) Ursula Fearon et al.   Nature Reviews Rheumatology

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2016) Ricard Garcia-Carbonell et al.   Arthritis & Rheumatology

K/BxN Serum-Transfer Arthritis as a Model for Human Inflammatory Arthritis

(2016) Anne D. Christensen et al.   Frontiers in Immunology

Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat

(2016) Jonatan Tuncel et al.   PLoS One

Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome

(2015) Arun Cumpelik et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia-inducible factor-1α perpetuates synovial fibroblast interactions with T cells and B cells in rheumatoid arthritis

(2015) Fanlei Hu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

(2015) Martin Kolev et al.   IMMUNITY

Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth

(2015) Liam G. Coulthard et al.   JOURNAL OF IMMUNOLOGY

How neutrophil extracellular traps orchestrate the local immune response in gout

(2015) Christian Maueröder et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

(2015) Sonia Carta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Interleukin-6 and its receptors: A highly regulated and dynamic system

(2014) Janina Wolf et al.   CYTOKINE

Complement C5a potentiates uric acid crystal-induced IL-1β production

(2014) Ling-Ling An et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

No Evidence of Pathogenic Involvement of Cathelicidins in Patient Cohorts and Mouse Models of Lupus and Arthritis

(2014) D. Kienhöfer et al.   PLoS One

Doxycycline-Induced Expression of Transgenic Human Tumor Necrosis Factor α in Adult Mice Results in Psoriasis-like Arthritis

(2013) Eugen Retser et al.   ARTHRITIS AND RHEUMATISM

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

ATP-P2X4 signaling mediates NLRP3 inflammasome activation: A novel pathway of diabetic nephropathy

(2013) Kehong Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1  Release

(2013) F. Laudisi et al.   JOURNAL OF IMMUNOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

(2012) Clifford D.L. Folmes et al.   Cell Stem Cell

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

MRI synovitis and bone lesions are common in acute gouty arthritis of the wrist even during the first attack

(2011) M. A. Cimmino et al.   ANNALS OF THE RHEUMATIC DISEASES

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cadherin-11 regulates fibroblast inflammation

(2011) S. K. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture

(2010) Hans P. Kiener et al.   ARTHRITIS AND RHEUMATISM

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes

(2009) Hans P. Kiener et al.   ARTHRITIS AND RHEUMATISM

Establishment of a matrix-associated transepithelial resistance invasion assay to precisely measure the invasive potential of synovial fibroblasts

(2009) Christina Wunrau et al.   ARTHRITIS AND RHEUMATISM

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Identification of a Novel Small Molecule HIF-1  Translation Inhibitor

(2009) T. Narita et al.   CLINICAL CANCER RESEARCH

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Gout

(2009) Pascal Richette et al.   LANCET

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

(2008) Maria Armaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE