标题
Drugging the efferocytosis process: concepts and opportunities
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-06-01
DOI
10.1038/s41573-022-00470-y
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Before the “cytokine storm”: Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications
- (2022) Somit Dutta et al. CYTOKINE & GROWTH FACTOR REVIEWS
- SCARF1-Induced Efferocytosis Plays an Immunomodulatory Role in Humans, and Autoantibodies Targeting SCARF1 Are Produced in Patients with Systemic Lupus Erythematosus
- (2022) April M. Jorge et al. JOURNAL OF IMMUNOLOGY
- Blocking TIM-3 in Treatment-refractory Advanced Solid Tumors: A Phase Ia/b Study of LY3321367 with or without an Anti-PD-L1 Antibody
- (2021) James J. Harding et al. CLINICAL CANCER RESEARCH
- Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus
- (2021) Johannes Hartl et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
- (2021) Luca Braga et al. NATURE
- Putting the brakes on phagocytosis: “don't‐eat‐me” signaling in physiology and disease
- (2021) Shannon M Kelley et al. EMBO REPORTS
- Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation
- (2021) Christopher B. Medina et al. IMMUNITY
- Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes
- (2021) Maedeh Arabpour et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- First-in-human phase 1 dose escalation study of HX009, a novel recombinant humanized anti-PD-1 and CD47 bispecific antibody, in patients with advanced malignancies.
- (2021) Aflah Roohullah et al. JOURNAL OF CLINICAL ONCOLOGY
- Trials in progress: A phase 1, open-label, dose-escalation, pharmacokinetic, safety and tolerability study of the selective TAM kinase inhibitor PF-07265807 in patients with advanced or metastatic solid tumors.
- (2021) Vivek Subbiah et al. JOURNAL OF CLINICAL ONCOLOGY
- Safety of AK117, an anti-CD47 monoclonal antibody, in patients with advanced or metastatic solid tumors in a phase I study.
- (2021) Hui Kong Gan et al. JOURNAL OF CLINICAL ONCOLOGY
- A first-in-human study of AO-176, a highly differentiated anti-CD47 antibody, in patients with advanced solid tumors.
- (2021) Howard A. Burris III et al. JOURNAL OF CLINICAL ONCOLOGY
- Development of a blocker of the universal phosphatidylserine- and phosphatidylethanolamine-dependent viral entry pathways
- (2021) Da-Hoon Song et al. VIROLOGY
- Deacetylation as a receptor-regulated direct activation switch for pannexin channels
- (2021) Yu-Hsin Chiu et al. Nature Communications
- Efficacy and Safety of Sabatolimab (MBG453) in Combination with Hypomethylating Agents (HMAs) in Patients (Pts) with Very High/High-Risk Myelodysplastic Syndrome (vHR/HR-MDS) and Acute Myeloid Leukemia (AML): Final Analysis from a Phase Ib Study
- (2021) Andrew M. Brunner et al. BLOOD
- Loss of myeloid cell-specific SIRPα, but not CD47, attenuates inflammation and suppresses atherosclerosis
- (2021) Bhupesh Singla et al. CARDIOVASCULAR RESEARCH
- Efferocytosis induces macrophage proliferation to help resolve tissue injury
- (2021) Brennan D. Gerlach et al. Cell Metabolism
- AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia
- (2021) Sean M. Post et al. HAEMATOLOGICA
- Phosphatidylserine receptors enhance SARS-CoV-2 infection
- (2021) Dana Bohan et al. PLoS Pathogens
- Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury
- (2020) Arif Yurdagul et al. Cell Metabolism
- A phase Ib/II study of the anti-CD47 antibody magrolimab with cetuximab in solid tumor and colorectal cancer patients.
- (2020) George A. Fisher et al. JOURNAL OF CLINICAL ONCOLOGY
- Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis
- (2020) Alyssa M. Flores et al. Nature Nanotechnology
- Mesenchymal Stem Cells Promote the Resolution of Cardiac Inflammation After Ischemia Reperfusion Via Enhancing Efferocytosis of Neutrophils
- (2020) Zeyu Zhang et al. Journal of the American Heart Association
- Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure
- (2020) Evangelos J. Giamarellos-Bourboulis et al. Cell Host & Microbe
- Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis
- (2020) Francisco Alejandro Lagunas-Rangel JOURNAL OF MEDICAL VIROLOGY
- Metabolites released from apoptotic cells act as tissue messengers
- (2020) Christopher B. Medina et al. NATURE
- Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
- (2020) Roel P. H. De Maeyer et al. NATURE IMMUNOLOGY
- The clearance of dead cells by efferocytosis
- (2020) Emilio Boada-Romero et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system
- (2020) Justus Huelse et al. PHARMACOLOGY & THERAPEUTICS
- Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome
- (2020) Elizabeth A Middleton et al. BLOOD
- Severe COVID-19 is marked by a dysregulated myeloid cell compartment
- (2020) Jonas Schulte-Schrepping et al. CELL
- In situ neutrophil efferocytosis shapes T cell immunity to influenza infection
- (2020) Kihong Lim et al. NATURE IMMUNOLOGY
- Mertk Interacts with Tim-4 to Enhance Tim-4-Mediated Efferocytosis
- (2020) Byeongjin Moon et al. Cells
- Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm
- (2020) Yun Young Lee et al. BIOMATERIALS
- TP-0903 is active in models of drug-resistant acute myeloid leukemia
- (2020) Jae Yoon Jeon et al. JCI Insight
- LC3-associated phagocytosis at a glance
- (2019) Bradlee L. Heckmann et al. JOURNAL OF CELL SCIENCE
- MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation
- (2019) Chihiro Nishi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology
- (2019) Sho Morioka et al. IMMUNITY
- Phosphatidylserine receptor-targeting therapies for the treatment of cancer
- (2019) Miso Park et al. ARCHIVES OF PHARMACAL RESEARCH
- Resolvin D1 promotes the targeting and clearance of necroptotic cells
- (2019) Brennan D. Gerlach et al. CELL DEATH AND DIFFERENTIATION
- Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma
- (2019) Seon Min Woo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Immunogenic cell death in cancer therapy: Present and emerging inducers
- (2019) Jingyi Zhou et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy
- (2019) Amira A. Barkal et al. NATURE
- 12(S)-Hydroxyeicosatetraenoic acid downregulates monocyte-derived macrophage efferocytosis: New insights in atherosclerosis
- (2019) Chiara Maria Manega et al. PHARMACOLOGICAL RESEARCH
- TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis
- (2019) Bethany Brunton et al. PLoS Neglected Tropical Diseases
- Lysosomal Cholesterol Hydrolysis Couples Efferocytosis To Anti-Inflammatory Oxysterol Production
- (2019) S. Ivanov et al. ATHEROSCLEROSIS
- TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti–PD-1 Therapy in Melanoma
- (2019) Alisha Holtzhausen et al. Cancer Immunology Research
- ROCK Inhibition Drives Resolution of Acute Inflammation by Enhancing Neutrophil Apoptosis
- (2019) Izabela Galvão et al. Cells
- Apoptosis inhibition by intracellular bacteria and its consequence on host immunity
- (2019) Samuel M Behar et al. CURRENT OPINION IN IMMUNOLOGY
- Resolvin D1 promotes efferocytosis in aging by limiting senescent cell‐induced MerTK cleavage
- (2019) Nicholas Rymut et al. FASEB JOURNAL
- Multifaceted Roles of TIM-Family Proteins in Virus–Host Interactions
- (2019) John P. Evans et al. TRENDS IN MICROBIOLOGY
- Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway
- (2019) Justin S. A. Perry et al. NATURE CELL BIOLOGY
- Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure
- (2019) Bochra Tourki et al. Molecular Metabolism
- Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol ProductionNovelty and Significance
- (2018) Manon Viaud et al. CIRCULATION RESEARCH
- TP-0903 inhibits neuroblastoma cell growth and enhances the sensitivity to conventional chemotherapy
- (2018) Sanja Aveic et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Impaired efferocytosis and neutrophil extracellular traps clearance by macrophages in ARDS
- (2018) Murielle Grégoire et al. EUROPEAN RESPIRATORY JOURNAL
- Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis
- (2018) Yuxuan Zhen et al. JOURNAL OF AUTOIMMUNITY
- Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase
- (2018) Mahiru Kawano et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SIRPα–CD47 Immune Checkpoint Blockade in Anticancer Therapy
- (2018) André Veillette et al. TRENDS IN IMMUNOLOGY
- Protein S and Gas6 induce efferocytosis of HIV-1-infected cells
- (2018) Bernadette Anne Chua et al. VIROLOGY
- Tim-4 promotes the growth of colorectal cancer by activating angiogenesis and recruiting tumor-associated macrophages via the PI3K/AKT/mTOR signaling pathway
- (2018) Xiao Tan et al. CANCER LETTERS
- A phase 1a / 1b first-in-human, open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of oral TP-0903, a potent inhibitor of AXL kinase, administered daily for 21 days to patients with advanced solid tumors.
- (2018) John Sarantopoulos et al. JOURNAL OF CLINICAL ONCOLOGY
- MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity
- (2018) Bishuang Cai et al. Science Signaling
- Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair
- (2018) Shuang Zhang et al. Cell Metabolism
- Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release
- (2018) Sho Morioka et al. NATURE
- MDSC; the Most Important Cell You Have Never Heard Of
- (2018) R.J. Tesi TRENDS IN PHARMACOLOGICAL SCIENCES
- Inhibition of inflammasome activation by a clinical strain of Klebsiella pneumoniae impairs efferocytosis and leads to bacterial dissemination
- (2018) Ana Campos Codo et al. Cell Death & Disease
- Role of the Specialized Proresolving Mediator Resolvin D1 in Systemic Lupus Erythematosus: Preliminary Results
- (2018) Luca Navarini et al. Journal of Immunology Research
- The deficiency of macrophage erythropoietin signaling contributes to delayed acute inflammation resolution in diet-induced obese mice
- (2018) Bangwei Luo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment
- (2017) Sushil Kumar et al. IMMUNOLOGICAL REVIEWS
- Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells
- (2017) Brian Sims et al. International Journal of Nanomedicine
- CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis
- (2017) Amanda C. Doran et al. JOURNAL OF CLINICAL INVESTIGATION
- MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis
- (2017) Bishuang Cai et al. JOURNAL OF CLINICAL INVESTIGATION
- Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses
- (2017) Michael R. Elliott et al. JOURNAL OF IMMUNOLOGY
- ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection
- (2017) Arup Sarkar et al. JOURNAL OF INFECTIOUS DISEASES
- PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
- (2017) Sydney R. Gordon et al. NATURE
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis
- (2017) Xunde Xian et al. eLife
- Pro-Resolving Mediators in Regulating and Conferring Macrophage Function
- (2017) Jesmond Dalli et al. Frontiers in Immunology
- Context-dependent compensation among phosphatidylserine-recognition receptors
- (2017) Kristen K. Penberthy et al. Scientific Reports
- Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
- (2016) Brandon M. Hall et al. Aging-US
- The clearance of dying cells: table for two
- (2016) D R Green et al. CELL DEATH AND DIFFERENTIATION
- Do not let death do us part: ‘find-me’ signals in communication between dying cells and the phagocytes
- (2016) C B Medina et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
- (2016) Christopher D. Wiley et al. Cell Metabolism
- Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE
- (2016) Jacob J. Orme et al. CLINICAL IMMUNOLOGY
- The Dynamics of Apoptotic Cell Clearance
- (2016) Michael R. Elliott et al. DEVELOPMENTAL CELL
- Epigenetic regulation of the glucose transporter geneSlc2a1by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice
- (2016) Kosuke Tanegashima et al. GENES TO CELLS
- ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia
- (2016) N. Arashiki et al. HAEMATOLOGICA
- Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial
- (2016) Nicola G. Ghazi et al. HUMAN GENETICS
- Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance
- (2016) Bangwei Luo et al. IMMUNITY
- Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo
- (2016) Chang Sup Lee et al. IMMUNITY
- Fasudil ameliorates fibrosis, vasculopathy, and immune abnormalities in animal models of systemic sclerosis
- (2016) Tetsuo Toyama et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
- (2016) Yoko Kojima et al. NATURE
- MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation
- (2016) Bishuang Cai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria
- (2016) Emily A. Billings et al. Science Signaling
- An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
- (2016) Gabrielle Fredman et al. Nature Communications
- Targeted delivery of microRNA-126 to vascular endothelial cells via REDV peptide modified PEG-trimethyl chitosan
- (2016) Fang Zhou et al. Biomaterials Science
- ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia
- (2016) N. Arashiki et al. HAEMATOLOGICA
- The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria
- (2016) Emily A. Billings et al. Science Signaling
- Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
- (2016) Valentina Cappello et al. Scientific Reports
- TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner
- (2015) Qianqian Zhang et al. BRITISH JOURNAL OF CANCER
- Impaired efferocytosis in human chronic granulomatous disease is reversed by pioglitazone treatment
- (2015) Ruby F. Fernandez-Boyanapalli et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1
- (2015) Aaron M. Fond et al. JOURNAL OF CLINICAL INVESTIGATION
- Preclinical combination of TP-0903, an AXL inhibitor and B-PAC-1, a procaspase-activating compound with ibrutinib in chronic lymphocytic leukemia
- (2015) Viralkumar Patel et al. LEUKEMIA & LYMPHOMA
- Necroptosis and its role in inflammation
- (2015) Manolis Pasparakis et al. NATURE
- Phagocytosis of apoptotic cells in homeostasis
- (2015) Sanja Arandjelovic et al. NATURE IMMUNOLOGY
- SLC transporters as therapeutic targets: emerging opportunities
- (2015) Lawrence Lin et al. NATURE REVIEWS DRUG DISCOVERY
- Increased soluble phagocytic receptors sMer, sTyro3 and sAxl and reduced phagocytosis in Juvenile-onset Systemic Lupus Erythematosus
- (2015) Lucy Ballantine et al. Pediatric Rheumatology
- TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets
- (2015) Toshihiro Fujii et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure
- (2015) Katsumori Segawa et al. TRENDS IN CELL BIOLOGY
- Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8+ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling
- (2015) F L Ribeiro-Gomes et al. Cell Death & Disease
- Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells
- (2015) Mikaella Vouri et al. Oncotarget
- Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors
- (2014) Monica Mita et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs
- (2014) C. Wilson et al. CANCER RESEARCH
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”
- (2014) Marcello Pinti et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Exposure of Phosphatidylserine by Xk-related Protein Family Members during Apoptosis
- (2014) Jun Suzuki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection
- (2014) Fanny Tzelepis et al. JOURNAL OF CLINICAL INVESTIGATION
- Milk Fat Globule Epidermal Growth Factor-Factor VIII Is Down-Regulated in Sepsis via the Lipopolysaccharide-CD14 Pathway
- (2014) H. Komura et al. JOURNAL OF IMMUNOLOGY
- Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nano-Proresolving Medicines
- (2014) Hildur H. Arnardottir et al. JOURNAL OF IMMUNOLOGY
- Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread
- (2014) Mark A. Czuczman et al. NATURE
- Causal effect of intergroup contact on exclusionary attitudes
- (2014) R. D. Enos PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells
- (2014) Hiroshi Yamaguchi et al. eLife
- Molecular Pathways: MERTK Signaling in Cancer
- (2013) C. T. Cummings et al. CLINICAL CANCER RESEARCH
- Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members
- (2013) Jun Suzuki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis
- (2013) Rebecca S. Cook et al. JOURNAL OF CLINICAL INVESTIGATION
- Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
- (2013) Gilad Doitsh et al. NATURE
- AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells
- (2013) M K Asiedu et al. ONCOGENE
- Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response
- (2013) D. Tseng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Engineered SIRP Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies
- (2013) K. Weiskopf et al. SCIENCE
- Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells
- (2013) J. Suzuki et al. SCIENCE
- Preclinical Potency and Safety Studies of an AAV2-Mediated Gene Therapy Vector for the Treatment of MERTK Associated Retinitis Pigmentosa
- (2013) Thomas J. Conlon et al. Human Gene Therapy Clinical Development
- Immunogenic Cell Death in Cancer Therapy
- (2012) Guido Kroemer et al. Annual Review of Immunology
- A phase I, first-in-human dose-escalation study of amuvatinib, a multi-targeted tyrosine kinase inhibitor, in patients with advanced solid tumors
- (2012) Raoul Tibes et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: a role for oxidized polyunsaturated fatty acids?
- (2012) Ulisse Garbin et al. CARDIOVASCULAR RESEARCH
- The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry
- (2012) Laurent Meertens et al. Cell Host & Microbe
- Efferocytosis Is an Innate Antibacterial Mechanism
- (2012) Constance J. Martin et al. Cell Host & Microbe
- Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction
- (2012) G. Zizzo et al. JOURNAL OF IMMUNOLOGY
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- The Soluble Serum Protein Gas6 Bridges Virion Envelope Phosphatidylserine to the TAM Receptor Tyrosine Kinase Axl to Mediate Viral Entry
- (2011) Kouki Morizono et al. Cell Host & Microbe
- Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)
- (2011) Edward Thorp et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Four faces of cellular senescence
- (2011) Francis Rodier et al. JOURNAL OF CELL BIOLOGY
- Functional Complement C1q Abnormality Leads to Impaired Immune Complexes and Apoptotic Cell Clearance
- (2011) Lubka T. Roumenina et al. JOURNAL OF IMMUNOLOGY
- Involvement of Adenosine A2A Receptors in Engulfment-Dependent Apoptotic Cell Suppression of Inflammation
- (2011) K. Koroskenyi et al. JOURNAL OF IMMUNOLOGY
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Constitutive exposure of phosphatidylserine on viable cells
- (2011) K. Segawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus
- (2011) A. S. Kondratowicz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
- (2010) S. J. Holland et al. CANCER RESEARCH
- Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma
- (2010) Mark P. Chao et al. CELL
- Ageing is associated with diminished apoptotic cell clearance in vivo
- (2010) T. Aprahamian et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages
- (2010) Camila Marques-da-Silva et al. IMMUNOBIOLOGY
- Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages
- (2010) A. A. Filardy et al. JOURNAL OF IMMUNOLOGY
- Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
- (2010) Faraaz B. Chekeni et al. NATURE
- Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
- (2010) Savita Khanna et al. PLoS One
- Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice
- (2009) Duo-Jiao Wu et al. ATHEROSCLEROSIS
- The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes
- (2009) Chongren Tang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
- (2009) Siddhartha Jaiswal et al. CELL
- CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells
- (2009) Ravindra Majeti et al. CELL
- Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet
- (2009) Suzhao Li et al. CIRCULATION RESEARCH
- The Phosphatidylserine Receptor TIM-4 Does Not Mediate Direct Signaling
- (2009) Daeho Park et al. CURRENT BIOLOGY
- Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR
- (2009) Noelia A-Gonzalez et al. IMMUNITY
- The Peroxisome Proliferator-Activated Receptor Agonist Pioglitazone Improves Cardiometabolic Risk and Renal Inflammation in Murine Lupus
- (2009) W. Zhao et al. JOURNAL OF IMMUNOLOGY
- Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
- (2009) Michael R. Elliott et al. NATURE
- Antiinflammatory effect of Rho kinase blockade via inhibition of NF-κB activation in rheumatoid arthritis
- (2008) Ya He et al. ARTHRITIS AND RHEUMATISM
- CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
- (2008) L. A. Truman et al. BLOOD
- Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal
- (2008) David R. Gude et al. FASEB JOURNAL
- Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells
- (2008) Richard K. Tsai et al. JOURNAL OF CELL BIOLOGY
- MerTK is required for apoptotic cell–induced T cell tolerance
- (2008) Mark A. Wallet et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Extracorporeal Photopheresis After Lung Transplantation: A 10-Year Single-Center Experience
- (2008) Christian Benden et al. TRANSPLANTATION
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now