Article
Hematology
Zeinab Hosseini, Michael Marinello, Christa Decker, Brian E. Sansbury, Sudeshna Sadhu, Brennan D. Gerlach, Ramon Bossardi Ramos, Alejandro P. Adam, Matthew Spite, Gabrielle Fredman
Summary: The study found that necroptotic cells impact resolution programs in atherosclerotic plaques and impair macrophages' clearance abilities. RvD1 may serve as a potential therapeutic strategy to limit necroptotic cells.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Hadas Pahima, Tresa George, David Mankuta, Ron Eliashar, Ekaterini Tiligada, Bruce D. Levy, Francesca Levi-Schaffer
Summary: This study investigates the pro-resolution role of mast cells in allergic inflammation. The results show that activated mast cells release a significant amount of resolvin D1 after 30 minutes, which can actively contribute to the resolution of allergic inflammation.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Noy Pinto, Yehuda Klein, Eilon David, David Polak, Daniel Steinberg, Gilad Mizrahi, Yasmin Khoury, Yechezkel Barenholz, Stella Chaushu
Summary: In this study, the effect of endogenous lipid RvD1 on allograft osteointegration in alveolar bone regeneration was investigated. Repeated administrations of RvD1 were found to promote bone regeneration through enhancing osteoblasts' differentiation and reducing osteoclastogenesis. This suggests that RvD1 may be a potential therapeutic bioagent for osseous regeneration following allograft implantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Linjun Chen, Yixuan Huang, Yizhen Chen, Jiaxuan Chen, Xueye You, Laiyu Zou, Jiabing Chen, Zhixin Chen, Xiaozhong Wang, Yuehong Huang
Summary: This study explored the effects of resolvin D1 (RvD1) on a rat model of acute-on-chronic liver failure (ACLF). The results showed that a low dose of RvD1 can promote the resolution of inflammation in ACLF rats by increasing the proportion of regulatory T cells (Treg). Therefore, RvD1 may be used as a potential drug for the treatment of patients with ACLF.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Pharmacology & Pharmacy
Ye Zhao, Teng Ma, Zhihan Zhang, Xi Chen, Chunhua Zhou, Ling Zhang, Duowu Zou
Summary: Resolvin D1 (RvD1) has a protective role in esophageal epithelial cells against acid-induced DNA damage, primarily by inhibiting ROS production and facilitating DSB repair through binding to FPR2. Studies in patients with refractory GERD and rat models suggest that RvD1 may be a promising approach for the treatment of GERD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Georgia K. Atkin-Smith
Summary: The clearance of dying cells is a well-defined process involving molecular factors and different mechanisms for different types of cell death. It is essential for preventing excessive release of pro-inflammatory mediators and inflammatory diseases.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Surgery
Regina Sordi, Fausto Chiazza, Debora Collotta, Giuseppe Migliaretti, Romain A. Colas, Paul Vulliamy, Karim Brohi, Jesmond Dalli, Massimo Collino, Christoph Thiemermann
Summary: The study found that trauma results in a significant reduction in plasma levels of resolvin D1 in patients. In rat experiments, RvD1 has a protective effect on organ damage and dysfunction caused by hemorrhagic shock.
Review
Biochemistry & Molecular Biology
Ali Roohbakhsh, Leila Etemad, Gholamreza Karimi
Summary: Resolvin D1 (RvD1), an endogenous lipid mediator with significant anti-inflammatory properties, has emerged as a potential therapeutic agent for various neurological diseases and dysfunctions. It is produced from omega-3 polyunsaturated fatty acid and shows promising effects at nanomolar and micromolar concentrations.
Article
Biochemistry & Molecular Biology
Josiah E. E. Hardesty, Jeffrey B. B. Warner, Ying L. L. Song, Eric C. C. Rouchka, Craig J. J. McClain, Dennis R. R. Warner, Irina A. A. Kirpich
Summary: Alcohol-associated liver disease (ALD) is a major health issue with limited treatment options. Alcohol-associated hepatitis (AH) is a severe form of ALD and has a high mortality rate. This study investigated the therapeutic efficacy and mechanisms of Resolvin D1 (RvD1) in treating liver injury and inflammation in an animal model of severe AH.
Article
Cell & Tissue Engineering
Xiaofeng Jiang, Jing Liu, Si Li, Yingfei Qiu, Xiaoli Wang, Xiaoli He, Torbjorn O. Pedersen, Kamal Mustafa, Ying Xue, Manal Mustafa, Alpdogan Kantarci, Zhe Xing
Summary: This study demonstrates that RvD1 enhances bone formation and vascularization in rat calvarial defects.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Cell Biology
Xiaoying Wang, Mingfeng Yang, Guanghui Yu, Jianhong Qi, Qingwei Jia, Shuai Liu, Wenjun Jiang, Siwei Su, Zhiwei Chi, Ruonan Wang, Minghan Liu, Hongqiang Song
Summary: Osteoarthritis (OA) is a common degenerative joint disease in middle-aged and older individuals. This study found that chondrocytes, the cells in joint cartilage, are difficult to heal after pyroptosis, leading to worsened cartilage wear and tear and affecting the progression of OA. By regulating the NLRP3/caspase-1 signaling pathway, Resolvin D1 (RvD1) promotes the proliferation of OA chondrocytes, repairs articular cartilage, and delays the progression of osteoarthritis.
CELLULAR SIGNALLING
(2024)
Article
Biotechnology & Applied Microbiology
Wenjun Jiang, Xiaoying Wang, Siwei Su, Sen Du, Hongqiang Song
Summary: RvD1 may inhibit the development of OA through the inhibition of NF/kB, p53, MAPK/JNK, PI3K-AKT signaling pathways, and may serve as a treatment for OA.
Article
Pharmacology & Pharmacy
Menglong Wang, Jishou Zhang, Mengmeng Zhao, Jianfang Liu, Jing Ye, Yao Xu, Zhen Wang, Di Ye, Dan Li, Jun Wan
Summary: This study demonstrates that RvD1 attenuates Dox-induced cardiac injury through improving cardiac function, reducing apoptosis and oxidative stress, and inhibiting inflammation and endoplasmic reticulum stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ameya A. Dravid, Kaamini Dhanabalan, Smriti Agarwal, Rachit Agarwal
Summary: A nanoliposomal formulation loaded with RvD1 has been developed to target and resolve osteoarthritis-associated inflammation. This controlled-release formulation effectively treats OA and relieves pain by inhibiting inflammatory activity and recruiting M2 macrophages, preventing cartilage damage and osteophyte formation.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Ying Zhang, Qianyu Zhang, Zheng Chu, Lin Chen, Jiayun Chen, Yang Yang, Huan Tang, Guangqing Cheng, Ang Ma, Chen Wang, Peng Gao, Fei Xia, Qiuyan Guo, Qiaoli Shi, Guang Han, Jigang Wang, Yinhua Zhu
Summary: Oridonin, derived from traditional Chinese medicine, is identified as a novel senolytic that may activate ROS-p38 signaling and induce apoptosis in senescent cells.
CHEMICAL COMMUNICATIONS
(2022)
Article
Oncology
Kate Tubbesing, Jamie Ward, Raymond Abini-Agbomson, Aditi Malhotra, Alena Rudkouskaya, Janine Warren, John Lamar, Nina Martino, Alejandro P. Adam, Margarida Barroso
MOLECULAR CANCER RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Guoning Liao, Ruping Wang, Dale D. Tang
Summary: This study found that Polo-like kinase 1 (Plk1) participates in the regulation of smooth muscle apoptosis in the airway, affecting airway smooth muscle thickening and remodeling through the phosphorylation of Caspase-9. This discovery reveals an important new target for asthma treatment.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ruping Wang, Yinna Wang, Guoning Liao, Bohao Chen, Reynold A. Panettieri, Raymond B. Penn, Dale D. Tang
Summary: Asthma is a complex pulmonary disorder with multiple pathological mechanisms. A key pathological feature is airway remodeling, which is largely caused by the abnormal proliferation of airway smooth muscle cells. An adapter protein called Abi1 has been identified as a molecular switch that regulates the activation of certain proteins and contributes to the progression of asthma.
Article
Cell Biology
Ruping Wang, Eylon Arbel, Dale D. Tang
Summary: This study demonstrates that smooth muscle myosin localizes at the leading edge of cells and orchestrates the recruitment of actin-regulatory proteins, promoting cell migration.
Article
Cell Biology
Ruping Wang, Sakeeb Khan, Guoning Liao, Yidi Wu, Dale D. Tang
Summary: This study found that nestin promotes the migration of smooth muscle cells by regulating Plk1 phosphorylation, which in turn regulates vimentin phosphorylation, the connection of vimentin filaments with paxillin, and focal adhesion assembly.
Review
Cell Biology
Nazia Habib, Muhammad Asghar Pasha, Dale D. Tang
Summary: Asthma is a heterogeneous lung disease with different phenotypes and endotypes. Th2 inflammation is the most important pathological process, although non-Th2 cytokines can also mediate asthma. Inflammation-independent processes contribute to asthma pathogenesis. Targeting newly identified molecules and practical biomarkers can improve the diagnosis, classification, and treatment of asthma.
Editorial Material
Biochemistry & Molecular Biology
Dale D. Tang
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wei Zhang, Jinjing Zhao, Lin Deng, Nestor Ishimwe, Jessica Pauli, Wen Wu, Shengshuai Shan, Wolfgang Kempf, Margaret D. Ballantyne, David Kim, Qing Lyu, Matthew Bennett, Julie Rodor, Adam W. Turner, Yao Wei Lu, Ping Gao, Mihyun Choi, Ganesh Warthi, Ha Won Kim, Margarida M. Barroso, William B. Bryant, Clint L. Miller, Neal L. Weintraub, Lars Maegdefessel, Joseph M. Miano, Andrew H. Baker, Xiaochun Long
Summary: The study discovered that INKILN is involved in the regulation of vascular smooth muscle cell (VSMC) inflammation and plays a role in the development of atherosclerosis and abdominal aortic aneurysm. INKILN activates the expression of inflammatory genes through interaction with MKL1 in VSMCs. This study provides a novel and physiologically relevant approach for investigating human-specific long noncoding RNAs under vascular disease conditions.
Editorial Material
Cell Biology
Steven An, Dale D. Tang
Review
Pharmacology & Pharmacy
Margarida Barroso, Michael G. Monaghan, Raluca Niesner, Ruslan I. Dmitriev
Summary: Organoid models play a crucial role in bioengineering applications, addressing developmental and cancer biology, tissue repair, etc. Their complexity makes them suitable for novel imaging methods like FLIM to study cell metabolism.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Allergy
Guoning Liao, Ruping Wang, Yidi Wu, Neelam Kumari Maheshwari, Raymond B. Penn, Dale D. Tang
Article
Multidisciplinary Sciences
Ling Wang, Joshua Goldwag, Megan Bouyea, Jonathan Barra, Kailie Matteson, Niva Maharjan, Amina Eladdadi, Mark J. Embrechts, Xavier Intes, Uwe Kruger, Margarida Barroso
Summary: We proposed a new methodology, organelle topology-based cell classification pipeline (OTCCP), that accurately classifies cancer cells based on their organelle spatial topology. OTCCP integrates artificial intelligence and imaging quantification to analyze organelle distribution and inter-organelle topology. Organelle topology allows for precise differentiation between cell lines of different subtypes and aggressiveness.
Article
Biophysics
Jason T. Smith, Nattawut Sinsuebphon, Alena Rudkouskaya, Xavier Michalet, Xavier Intes, Margarida Barroso
Summary: Forster resonance energy transfer (FRET) microscopy is widely used for monitoring molecular interactions and conformational changes. It has been extended to in vivo optical imaging, particularly for quantifying drug-target engagement or release in cancer models. This study compares intensity-based FRET and macroscopic fluorescence lifetime (MFLI) FRET for small animal optical in vivo imaging and demonstrates that MFLI-FRET has significant advantages.
BIOPHYSICAL REPORTS
(2023)