MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis

(2017) Amanda C. Doran et al.   JOURNAL OF CLINICAL INVESTIGATION

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

(2017) Bishuang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation

(2016) Hildur H. Arnardottir et al.   JOURNAL OF IMMUNOLOGY

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response

(2016) Viralkumar Davra et al.   Cancers

Toll-Like Receptor 2-Dependent Extracellular Signal-Regulated Kinase Signaling in Mycobacterium tuberculosis-Infected Macrophages Drives Anti-Inflammatory Responses and Inhibits Th1 Polarization of Responding T Cells

(2015) Edward T. Richardson et al.   INFECTION AND IMMUNITY

Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation

(2015) Ji-Yeon Choi et al.   Science Signaling

Atherosclerosis – A matter of unresolved inflammation

(2015) Joana Viola et al.   SEMINARS IN IMMUNOLOGY

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

(2015) Simon C. Dyall   Frontiers in Aging Neuroscience

Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation

(2015) Ji-Yeon Choi et al.   Science Signaling

Modulation of Intracellular Calcium Levels by Calcium Lactate Affects Colon Cancer Cell Motility through Calcium-Dependent Calpain

(2015) Pasupathi Sundaramoorthy et al.   PLoS One

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

(2014) J. Newson et al.   BLOOD

TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis

(2014) J. H. M. van der Meer et al.   BLOOD

CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury

(2014) M. Weinreuter et al.   EMBO Molecular Medicine

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Calcium/calmodulin-dependent protein kinase II regulates cyclooxygenase-2 expression and prostaglandin E2production by activating cAMP-response element-binding protein in rat peritoneal macrophages

(2014) Xueyuan Zhou et al.   IMMUNOLOGY

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

(2014) Wen-I Tsou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

(2014) Erin D Lew et al.   eLife

Avicularin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Suppressing ERK Phosphorylation in RAW 264.7 Macrophages

(2013) Van Anh Vo et al.   Biomolecules & Therapeutics

Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Obesity Mediates Suppression of Hepatic Insulin Signaling

(2013) Lale Ozcan et al.   Cell Metabolism

Molecular Pathways: MERTK Signaling in Cancer

(2013) C. T. Cummings et al.   CLINICAL CANCER RESEARCH

MERTK receptor tyrosine kinase is a therapeutic target in melanoma

(2013) Jennifer Schlegel et al.   JOURNAL OF CLINICAL INVESTIGATION

Biology of the TAM Receptors

(2013) G. Lemke   Cold Spring Harbor Perspectives in Biology

Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia

(2013) L N Brandao et al.   Blood Cancer Journal

Calcium Signaling through CaMKII Regulates Hepatic Glucose Production in Fasting and Obesity

(2012) Lale Ozcan et al.   Cell Metabolism

Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment

(2012) C.-P. Liang et al.   DIABETES

Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury

(2012) Ye-Ji Lee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ca2+/calmodulin-dependent protein kinase II function in vascular remodelling

(2011) Harold A. Singer   JOURNAL OF PHYSIOLOGY-LONDON

MEK/ERK Inhibitor U0126 Increases the Radiosensitivity of Rhabdomyosarcoma Cells In vitro and In vivo by Downregulating Growth and DNA Repair Signals

(2011) F. Marampon et al.   MOLECULAR CANCER THERAPEUTICS

TAM receptors and the clearance of apoptotic cells

(2010) Greg Lemke et al.   Annals of the New York Academy of Sciences

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis

(2009) Taisuke Ohira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress

(2009) Adil Anwar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma

(2009) F. Marampon et al.   MOLECULAR CANCER THERAPEUTICS

Defective Mer Receptor Tyrosine Kinase Signaling in Bone Marrow Cells Promotes Apoptotic Cell Accumulation and Accelerates Atherosclerosis

(2008) Hafid Ait-Oufella et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Wnt5A/CaMKII Signaling Contributes to the Inflammatory Response of Macrophages and Is a Target for the Antiinflammatory Action of Activated Protein C and Interleukin-10

(2008) Claudia Pereira et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe −/− Mice

(2008) Edward Thorp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages

(2008) X. Liu et al.   BLOOD

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

(2008) J. Bystrom et al.   BLOOD

The Role of Calmodulin Kinase II in Myocardial Physiology and Disease

(2008) Luis F. Couchonnal et al.   PHYSIOLOGY