Review
Immunology
Matheus B. Carneiro, Nathan C. Peters
Summary: This review focuses on the interaction between Leishmania amazonensis infection and host innate immune response, particularly addressing the impact of adaptive immunity on phagocytic host cell recruitment and activation. Experimental observations indicate that most mouse strains are susceptible to L. amazonensis infection, unlike other Leishmania species. The CD4(+) T helper (Th)1/Th2 paradigm does not fully explain the chronic disease established by L. amazonensis, with recent findings complicating the understanding of the Th1/Th2 paradigm.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kyungtaek Im, Yun Jung Choi, Dong Ha Kim, Da -Som Kim, Kyosun Ban, Wonjun Ji, In-Jeoung Baek, Chang-Min Choi, Jae Cheol Lee, Jin Kyung Rho
Summary: This study reveals that AXL inhibits the clonal expansion of tumor-specific CD8+ T cells through the regulation of CD8+ T cell and DC migration in the tumor microenvironment. AXL knockout suppresses tumor growth and induces an increased population of tumor-infiltrating CD8+ T cells and CD103+ DCs. Anti-PD-1 treatment shows synergistic anti-cancer effects in AXL-/- mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Florianne M. J. Hafkamp, Esther W. M. Taanman-Kueter, Toni M. M. van Capel, Tom Groot Kormelink, Esther C. de Jong
Summary: This study investigated the effects of Vitamin D3 on the differentiation of specific human T cells. The results showed that Vitamin D3 can restrict the development of Th17 cells, promote the development of regulatory T cells, and reduce the production of specific cytokines by dendritic cells. This provides potential for the use of Vitamin D3 as an adjuvant in the treatment of autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Adriana Valeria Jager, Paula Arias, Maria Virginia Tribulatti, Marcela Adriana Brocco, Maria Victoria Pepe, Arlinet Kierbel
Summary: This study elucidated the modulation of macrophage efferocytic function during an inflammatory stimulus. The results showed that macrophages efficiently engulf bacterial pathogens and apoptotic cells, and their efferocytic capacity increased significantly after processing bacteria. Furthermore, the study demonstrated that bacterial processing enhanced the efferocytosis of macrophages through the IL-6 signaling pathway.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Leonard R. Pelgrom, Thiago A. Patente, Frank Otto, Lonneke V. Nouwen, Arifa Ozir-Fazalalikhan, Alwin J. van der Ham, Hendrik J. P. van der Zande, Graham A. Heieis, Ramon Arens, Bart Everts
Summary: This study reveals that mTORC1 limits the activation of CD8(+) T cells in vivo by regulating the metabolism and immunogenicity of different subsets of antigen-presenting cells, but it does not affect antigen-specific CD8(+) T cell responses to infection.
Article
Multidisciplinary Sciences
Jessica Filtjens, Anais Roger, Linda Quatrini, Elisabeth Wieduwild, Jordi Gouilly, Guillaume Hoeffel, Rafaelle Rossignol, Clara Daher, Guilhaume Debroas, Sandrine Henri, Claerwen M. Jones, Bernard Malissen, Laura K. Mackay, Aziz Moqrich, Francis R. Carbone, Sophie Ugolini
Summary: The study demonstrates that Nav(1.8)(+) sensory neurons play a crucial role in regulating CD8 T cell immune responses against HSV-1 infection, affecting skin damage severity and cytokine production. Sensory neurons are also involved in controlling neutrophil infiltration and dendritic cell responses, highlighting their potential as a therapeutic target.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Sinead Kinsella, Cindy A. Evandy, Kirsten Cooper, Lorenzo Iovino, Paul C. DeRoos, Kayla S. Hopwo, David W. Granadier, Colton W. Smith, Shahin Rafii, Jarrod A. Dudakov
Summary: The study identifies a complex signal pathway triggered by apoptotic thymocytes during tissue damage, leading to increased production of IL-23 and BMP4 and ultimately promoting thymic regeneration. Pharmacological inhibition targeting this pathway enhances thymic function and offers a new strategy for restoring immune competence in patients with compromised thymic function.
Article
Biochemistry & Molecular Biology
Abigail K. Grootveld, Wunna Kyaw, Veera Panova, Angelica W. Y. Lau, Emily Ashwin, Guillaume Seuzaret, Rama Dhenni, Nayan Deger Bhattacharyya, Weng Hua Khoo, Mate Biro, Tanmay Mitra, Michael Meyer-Hermann, Patrick Bertolino, Masato Tanaka, David A. Hume, Peter I. Croucher, Robert Brink, Akira Nguyen, Oliver Bannard, Tri Giang Phan
Summary: Germinal centers (GCs) in lymphoid follicles during antibody responses are areas of extensive cell death. Tingible body macrophages (TBMs) derived from lymph node-resident, CD169-lineage, CSF1R-blockade-resistant precursor. Non-migratory TBMs use cytoplasmic processes to capture migrating dead cell fragments using a lazysearch strategy. Follicular macrophages can mature into TBMs in the absence of GCs and activated by the nearby apoptotic cells. Single-cell transcriptomics analysis identified upregulated genes related to apoptotic cell clearance in TBMs, which prevent autoimmune diseases.
Article
Oncology
Federico Simonetta, Juliane K. Lohmeyer, Toshihito Hirai, Kristina Maas-Bauer, Maite Alvarez, Arielle S. Wenokur, Jeanette Baker, Amin Aalipour, Xuhuai Ji, Samuel Haile, Crystal L. Mackall, Robert S. Negrin
Summary: The study assessed the antitumor effects of allogeneic CAR iNKT cells, demonstrating their ability to induce tumor-specific immunity across major MHC barriers and elicit potent antitumor responses from host CD8 T cells. This suggests that the use of off-the-shelf allogeneic CAR iNKT cells could address significant unmet needs in the clinic.
CLINICAL CANCER RESEARCH
(2021)
Review
Immunology
Kevin Schneider, Sanja Arandjelovic
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects about 1% of the human population. It is characterized by joint swelling and bone erosion, causing disability and even death. Immune dysregulation, including circulating autoantibodies and inflammatory mediators, plays an important role in the development of RA. Studies have shown that inducing cell death through apoptosis can reduce the severity of the disease. Apoptotic cells are cleared by phagocytes through a process called efferocytosis, which has anti-inflammatory properties. Dysfunctions in efferocytosis have been linked to autoimmune diseases, while administration of apoptotic cells in RA models effectively inhibits inflammation. However, the signaling pathways and clearance mediators involved in RA are still not well understood.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Cell Biology
Lei Yuan, Peiyao Li, Qian Zheng, Hui Wang, Hui Xiao
Summary: Ubiquitination and deubiquitination play important roles in apoptosis and apoptotic cell clearance, and are crucial for normal development and immune diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
George Papadopoulos, Robert Berland, Ashwini Sunkavalli, Stephen R. Coats, Richard P. Darveau, Caroline A. Genco
Summary: Most Gram-negative bacteria trigger a strong immune response through recognition of lipid A by Toll-like receptor 4, but some bacteria like Porphyromonas gingivalis alter their lipid A structure to evade detection and influence host adaptive immunity, leading to chronic infections associated with systemic inflammatory disorders.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Zhijuan Qiu, Camille Khairallah, Timothy H. H. Chu, Jessica N. N. Imperato, Xinyuan Lei, Galina Romanov, Amha Atakilit, Lynn Puddington, Brian S. S. Sheridan
Summary: CD8 tissue-resident memory T (T-RM) cells in barrier tissues provide frontline protection, but the mechanisms regulating their development are not completely understood. This study shows that T cell priming in the mesenteric lymph nodes (MLN) regulates the differentiation of CD103(+) T-RM cells in the intestine, while T cells primed in the spleen are impaired in this process. Licensing of differentiation is regulated by retinoic acid signaling and factors other than gut homing receptors.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Francisco J. Sanchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jacks
Summary: The level of mitochondrial apoptotic priming is a critical determinant of cell fate upon p53 reactivation, with cells having high initial priming tending to undergo apoptosis and cells with low priming tending to survive and arrest in the cell cycle. Manipulating the priming levels through BCL-2 or BCL-XL expression or inhibition can affect the outcome of p53 restoration, highlighting mitochondrial apoptotic priming as a key factor in determining cell fate. Moreover, less primed cells can be forced into apoptotic cell fate following p53 activation using p53-independent drugs that increase apoptotic priming.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Dae Joong Kim, Swetha Anandh, Jamie L. Null, Piotr Przanowski, Sanchita Bhatnagar, Pankaj Kumar, Sarah E. Shelton, Erin E. Grundy, Katherine B. Chiappinelli, Roger D. Kamm, David A. Barbie, Andrew C. Dudley
Summary: This study investigates the immunoregulatory functions of DNMT1 in the tumor vasculature. The deletion of Dnmt1 in endothelial cells slows tumor growth and promotes the expression of cell adhesion molecules and chemokines, facilitating the trafficking of CD8(+) T-cells across the vasculature and enhancing the efficacy of immune checkpoint blockade. Additionally, the study reveals that the proangiogenic factor FGF2 promotes DNMT1 phosphorylation and nuclear translocation, leading to the repression of chemokines in endothelial cells.
NATURE COMMUNICATIONS
(2023)
Review
Parasitology
Leah S. Hohman, Nathan C. Peters
TRENDS IN PARASITOLOGY
(2019)
Article
Immunology
Monica Losada-Barragan, Adriana Umana-Perez, Jonathan Duraes, Sergio Cuervo-Escobar, Andres Rodriguez-Vega, Flavia L. Ribeiro-Gomes, Luiz R. Berbert, Fernanda Morgado, Renato Porrozzi, Daniella Areas Mendes-da-Cruz, Priscila Aquino, Paulo C. Carvalho, Wilson Savino, Myriam Sanchez-Gomez, Gabriel Padron, Patricia Cuervo
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Microbiology
Matheus Batista Carneiro, Mateus Eustaquio Lopes, Leah S. Hohman, Audrey Romano, Bruna Araujo David, Rachel Kratofil, Paul Kubes, Matthew L. Workentine, Alexandre C. Campos, Leda Quercia Vieira, Nathan C. Peters
CELL HOST & MICROBE
(2020)
Article
Multidisciplinary Sciences
Saba Gul, Flavia L. Ribeiro-Gomes, Aline S. Moreira, Guilherme S. Sanches, Fabiana G. Conceicao, Claudio Tadeu Daniel-Ribeiro, Hans C. Ackerman, Leonardo J. M. Carvalho
Summary: The study showed that whole blood transfusion can effectively prevent further drop in hematocrit and partially restore platelet count after artemether treatment, and alleviate spleen congestion. Transfusion restored plasma Ang-2 level to quiescence, while Ang-1 in ECM mice could not be replenished by any treatment.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Luciana Pereira de Sousa, Flavia Lima Ribeiro-Gomes, Roberto Farina de Almeida, Tadeu Mello e Souza, Guilherme Loureiro Werneck, Diogo Onofre Souza, Claudio Tadeu Daniel-Ribeiro
Summary: Research shows that immune modulation induced by specific immune stimuli can enhance recognition memory in mice and reverse memory impairment and anxiety caused by mild malaria infection.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Leah S. Hohman, Zhirong Mou, Matheus B. Carneiro, Gabriel Ferland, Rachel M. Kratofil, Paul Kubes, Jude E. Uzonna, Nathan C. Peters
Summary: Intracellular infection with Leishmania major results in concomitant immunity mediated by CD4(+) Th1 cells. The timing and interaction between Th1 cells and infected monocytes play a critical role in protective immunity. Activation of phagocytic host cells by preactivated Th1 cells at the time of infection is essential for successful immune response.
Review
Immunology
Matheus B. Carneiro, Nathan C. Peters
Summary: This review focuses on the interaction between Leishmania amazonensis infection and host innate immune response, particularly addressing the impact of adaptive immunity on phagocytic host cell recruitment and activation. Experimental observations indicate that most mouse strains are susceptible to L. amazonensis infection, unlike other Leishmania species. The CD4(+) T helper (Th)1/Th2 paradigm does not fully explain the chronic disease established by L. amazonensis, with recent findings complicating the understanding of the Th1/Th2 paradigm.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Pamela Rosa-Goncalves, Flavia Lima Ribeiro-Gomes, Claudio Tadeu Daniel-Ribeiro
Summary: Malaria, caused by the protozoa Plasmodium, is a significant public health issue in tropical and subtropical regions. The disease can present with a range of symptoms, with cerebral malaria being the most severe and lethal complication. Survivors of cerebral malaria may experience neurological, cognitive, and behavioral sequelae. Recent studies suggest immunomodulation as a potential approach to prevent or reverse these neurocognitive sequelae of malaria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Nathan C. Peters, Nargis Khan, Christopher H. Mody
Summary: Prophylactic vaccination strategies targeting the phagolysosome for diseases caused by pathogens have been ineffective. The failure of these strategies, which mainly focus on CD4+ T cell mediated immune memory, calls for alternative approaches to activate phagocytic cells. This study proposes three novel approaches to prevent the formation of pathogen niche within the phagolysosome and suggests a greater emphasis on the timing of phagocyte activation for more effective prophylactic treatment options.
TRENDS IN IMMUNOLOGY
(2023)
Article
Immunology
Pamela Rosa-Goncalves, Luciana Pereira de Sousa, Aline Barbosa Maia, Flavia Lima Ribeiro-Gomes, Caroline Cristhiani Tavares de Lima Gress, Guilherme Loureiro Werneck, Diogo Onofre Souza, Roberto Farina Almeida, Claudio Tadeu Daniel-Ribeiro
Summary: The study suggests that immunization with immunogens that induce type 2 immune responses may reverse cognitive and behavioral impairments associated with malaria. This finding highlights the potential importance of researching and developing vaccines for the treatment and prevention of post-malaria sequelae.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pamela Rosa-Goncalves, Luciana Pereira de Sousa, Flavia Lima Ribeiro-Gomes, Leonardo Jose Moura Carvalho, Claudio Tadeu Daniel-Ribeiro
Summary: Malaria, caused by protozoa of the genus Plasmodium, is an ancient parasitic disease characterized by fever, headache, sweating, and chills. Neurological, neurocognitive, and behavioral alterations, as well as poor school performance, can develop in survivors. Neuroinflammation plays a crucial role in the cognitive dysfunctions associated with malaria. Vaccination with type 2 immune response elicitors, such as the tetanus-diphtheria vaccine, may have a beneficial effect in alleviating neuroinflammation and mitigating neurocognitive deficits.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Immunology
Uyla Ornellas-Garcia, Patricia Cuervo, Flavia Lima Ribeiro-Gomes
Summary: Malaria and leishmaniasis are endemic parasitic diseases in tropical and subtropical countries. Co-infection with Plasmodium spp. and Leishmania spp. can either exacerbate or suppress the immune response, impacting the clinical course and management of these diseases. Addressing the importance of concomitant infections is crucial for accurate diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Parasitology
Yuri Chaves Martins, Flavia Lima Ribeiro-Gomes, Claudio Tadeu Daniel-Ribeiro
Summary: Innate immunity is the first line of defense against pathogens, cancer cells, and toxins. It also plays a crucial role in activating the body's specific immune response. This overview highlights the key findings and ideas that have contributed to the development of innate immunity as a branch of modern immunology.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2023)
Meeting Abstract
Immunology
Leah S. Hohman, Matheus B. H. Carneiro, Rachel M. Kratofil, Nathan C. Peters
JOURNAL OF IMMUNOLOGY
(2021)
Article
Microbiology
Mariana M. Chaves, Sang Hun Lee, Olena Kamenyeva, Kashinath Ghosh, Nathan C. Peters, David Sacks