Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance

Encouraging the Development of New Antibiotics: Are Financial Incentives the Right Way Forward? A Systematic Review and Case Study

(2021) Ilinca A Dutescu et al.   Infection and Drug Resistance

Binding loop of sunflower trypsin inhibitor 1 serves as a design motif for proteolysis-resistant antimicrobial peptides

(2021) Chensi Wang et al.   Acta Biomaterialia

New Antimicrobial Peptides with Repeating Unit against Multidrug-Resistant Bacteria

(2021) Chao Zhong et al.   ACS Infectious Diseases

Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice

(2021) Sanhu Gou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes

(2021) Andra B. Schromm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effects of 6‐gingerol on 6‐hydroxydopamine‐induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation

(2021) Farzaneh‐Sadat Rezazadeh‐Shojaee et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Antimicrobial host defence peptides: functions and clinical potential

(2020) Neeloffer Mookherjee et al.   NATURE REVIEWS DRUG DISCOVERY

Enhanced cell selectivity of hybrid peptides with potential antimicrobial activity and immunomodulatory effect

(2020) Xiaokang Miao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Synthesis and anti-pseudomonal activity of new ß-Ala modified analogues of the antimicrobial peptide anoplin

(2020) Chao Zhong et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Cross‐Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified β‐Hairpin Antimicrobial Amphiphiles

(2020) Changxuan Shao et al.   Small

Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance

(2020) Chao Zhong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria

(2020) Ningyi Zhu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria

(2019) Jiajun Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioactivity and Bactericidal Mechanism of Histidine-Rich β-Hairpin Peptide Against Gram-Negative Bacteria

(2019) Na Dong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase

(2019) Bo Ma et al.   Nature Communications

Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria

(2019) Chao Zhong et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Study on the effects of different dimerization positions on biological activity of partial d-Amino acid substitution analogues of Anoplin

(2019) Chao Zhong et al.   MICROBIAL PATHOGENESIS

Central β-turn increases the cell selectivity of imperfectly amphipathic α-helical peptides

(2018) Changxuan Shao et al.   Acta Biomaterialia

Short arginine-rich lipopeptides: From self-assembly to antimicrobial activity

(2018) Emilia Sikorska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

OUP accepted manuscript

(2018)   CLINICAL INFECTIOUS DISEASES

Short Symmetric-End Antimicrobial Peptides Centered on β-Turn Amino Acids Unit Improve Selectivity and Stability

(2018) Na Dong et al.   Frontiers in Microbiology

The drug-resistant bacteria that pose the greatest health threats

(2017) Cassandra Willyard   NATURE

Adaptation of a bacterial membrane permeabilization assay for quantitative evaluation of benzalkonium chloride as a membrane-disrupting agent

(2017) Julien Gravel et al.   MedChemComm

Effects of Hydrophobic Amino Acid Substitutions on Antimicrobial Peptide Behavior

(2017) Kimberly D. Saint Jean et al.   Probiotics and Antimicrobial Proteins

The effects of LPS on the activity of Trp-containing antimicrobial peptides against Gram-negative bacteria and endotoxin neutralization

(2016) Dejing Shang et al.   Acta Biomaterialia

Hairpin structure stability plays a role in the activity of two antimicrobial peptides

(2016) Kalkena Sivanesam et al.   FEBS LETTERS

Past, Present, and Future of Antibacterial Economics: Increasing Bacterial Resistance, Limited Antibiotic Pipeline, and Societal Implications

(2016) Katherine H. Luepke et al.   PHARMACOTHERAPY

Antimicrobial activity and membrane-active mechanism of tryptophan zipper-like β-hairpin antimicrobial peptides

(2015) Lin Xu et al.   AMINO ACIDS

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Enhanced Amphiphilic Profile of a Short β-Stranded Peptide Improves Its Antimicrobial Activity

(2015) Giorgia Manzo et al.   PLoS One

High specific selectivity and Membrane-Active Mechanism of the synthetic centrosymmetric α-helical peptides with Gly-Gly pairs

(2015) Jiajun Wang et al.   Scientific Reports

Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials

(2014) Zhan Yuin Ong et al.   ADVANCED DRUG DELIVERY REVIEWS

The effects of the C-terminal amidation of mastoparans on their biological actions and interactions with membrane-mimetic systems

(2014) Alessandra V.R. da Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cysteine deleted protegrin-1 (CDP-1): Anti-bacterial activity, outer-membrane disruption and selectivity

(2014) Harini Mohanram et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antimicrobial potency and selectivity of simplified symmetric-end peptides

(2014) Na Dong et al.   BIOMATERIALS

Strand Length-Dependent Antimicrobial Activity and Membrane-Active Mechanism of Arginine- and Valine-Rich β-Hairpin-Like Antimicrobial Peptides

(2012) Na Dong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cationic Surfactants Derived from Lysine: Effects of Their Structure and Charge Type on Antimicrobial and Hemolytic Activities

(2011) A. Colomer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tryptophan residues: Scarce in proteins but strong stabilizers of β-hairpin peptides

(2010) Clara M. Santiveri et al.   BIOPOLYMERS

Structure and mechanism of β-hairpin antimicrobial peptides in lipid bilayers from solid-state NMR spectroscopy

(2009) Ming Tang et al.   Molecular BioSystems

Potential of immunomodulatory host defense peptides as novel anti-infectives

(2009) Donna M. Easton et al.   TRENDS IN BIOTECHNOLOGY

Using Fluorous Amino Acids To Probe the Effects of Changing Hydrophobicity on the Physical and Biological Properties of the β-Hairpin Antimicrobial Peptide Protegrin-1†

(2008) Lindsey M. Gottler et al.   BIOCHEMISTRY

The Role of Hydrophobicity in the Antimicrobial and Hemolytic Activities of Polymethacrylate Derivatives

(2008) Kenichi Kuroda et al.   CHEMISTRY-A EUROPEAN JOURNAL