New Antimicrobial Peptides with Repeating Unit against Multidrug-Resistant Bacteria

A glycosylated cationic block poly(beta-peptide) reverses intrinsic antibiotic resistance in all ESKAPE Gram-negative bacteria

(2020) Zhangyong Si et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) position statements on polymyxin B and colistin clinical breakpoints

(2020) Michael J Satlin et al.   CLINICAL INFECTIOUS DISEASES

Romo1-Derived Antimicrobial Peptide Is a New Antimicrobial Agent against Multidrug-Resistant Bacteria in a Murine Model of Sepsis

(2020) Hye-Ra Lee et al.   mBio

Experimental concepts for linking the biological activities of antimicrobial peptides to their molecular modes of action

(2020) Nermina Malanovic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mechanisms of antimicrobial and antiendotoxin activities of a triazine‐based amphipathic polymer

(2020) Eun Young Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Antimicrobial peptides as therapeutic agents: opportunities and challenges

(2020) Margit Mahlapuu et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Analogs of the Cathelicidin-Derived Antimicrobial Peptide PMAP-23 Exhibit Improved Stability and Antibacterial Activity

(2020) Yongqing Liu et al.   Probiotics and Antimicrobial Proteins

Effect of N-methylated and fatty acid conjugation on analogs of antimicrobial peptide Anoplin

(2020) Tianqi Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Syndiotactic Peptides for Targeted Delivery

(2019) Gaurav Jerath et al.   Acta Biomaterialia

Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria

(2019) Jiajun Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism

(2019) Yinfeng Lyu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

(2019) Biswajit Mishra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity

(2019) Chao Zhong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chimeric peptidomimetic antibiotics against Gram-negative bacteria

(2019) Anatol Luther et al.   NATURE

Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure–Function Relationships to Combat Drug-Resistant Fungi and Biofilms

(2019) Peng Tan et al.   ACS Applied Materials & Interfaces

Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria

(2019) Chao Zhong et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Central β-turn increases the cell selectivity of imperfectly amphipathic α-helical peptides

(2018) Changxuan Shao et al.   Acta Biomaterialia

Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm

(2018) Elizabeth A. Lakota et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fatty acid conjugated pyridinium cationic amphiphiles as antibacterial agents and self-assembling nano carriers

(2018) Pavan Walvekar et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides

(2018) Jiajun Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

(2018) Anna de Breij et al.   Science Translational Medicine

Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design

(2017) Jianguo Li et al.   Frontiers in Neuroscience

Hydrophilic Phage-Mimicking Membrane Active Antimicrobials Reveal Nanostructure-Dependent Activity and Selectivity

(2017) Yunjiang Jiang et al.   ACS Infectious Diseases

A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii

(2017) Mohamed F. Mohamed et al.   Scientific Reports

Mechanisms and consequences of bacterial resistance to antimicrobial peptides

(2016) D.I. Andersson et al.   DRUG RESISTANCE UPDATES

Designing α-helical peptides with enhanced synergism and selectivity against Mycobacterium smegmatis : Discerning the role of hydrophobicity and helicity

(2015) Jasmeet Singh Khara et al.   Acta Biomaterialia

Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them

(2014) Leonard Amaral et al.   Frontiers in Pharmacology

Design of imperfectly amphipathic α-helical antimicrobial peptides with enhanced cell selectivity

(2013) Xin Zhu et al.   Acta Biomaterialia

Effect of hydrophobic modifications in antimicrobial peptides

(2013) Artur Schmidtchen et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Correlations between membrane immersion depth, orientation, and salt-resistance of tryptophan-rich antimicrobial peptides

(2013) Hui-Yuan Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Anti-mycobacterial activities of synthetic cationic α-helical peptides and their synergism with rifampicin

(2013) Jasmeet S. Khara et al.   BIOMATERIALS

Design of short membrane selective antimicrobial peptides containing tryptophan and arginine residues for improved activity, salt-resistance, and biocompatibility

(2013) Rathi Saravanan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Trough colistin plasma level is an independent risk factor for nephrotoxicity: a prospective observational cohort study

(2013) Luisa Sorlí et al.   BMC INFECTIOUS DISEASES

Clinical relevance of the ESKAPE pathogens

(2013) Jack N Pendleton et al.   Expert Review of Anti-Infective Therapy

Dynamic Turn Conformation of a Short Tryptophan-Rich Cationic Antimicrobial Peptide and Its Interaction with Phospholipid Membranes

(2013) Matthew Nichols et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Different Interactions of Lysine and Arginine Side Chains with Lipid Membranes

(2013) Libo Li et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Design of hybrid β-hairpin peptides with enhanced cell specificity and potent anti-inflammatory activity

(2012) YiFan Liu et al.   BIOMATERIALS

Divalent cations modulate membrane binding and pore formation of a potent antibiotic peptide analog of alamethicin

(2012) Marco Aquila et al.   CELL CALCIUM

Rationally Designed α-Helical Broad-Spectrum Antimicrobial Peptides with Idealized Facial Amphiphilicity

(2012) Nikken Wiradharma et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Role of lipids in the interaction of antimicrobial peptides with membranes

(2012) Vitor Teixeira et al.   PROGRESS IN LIPID RESEARCH

Tryptophan-Lipid Interactions in Membrane Protein Folding Probed by Ultraviolet Resonance Raman and Fluorescence Spectroscopy

(2011) Katheryn M. Sanchez et al.   BIOPHYSICAL JOURNAL

Designing antimicrobial peptides: form follows function

(2011) Christopher D. Fjell et al.   NATURE REVIEWS DRUG DISCOVERY

Synthetic cationic amphiphilic α-helical peptides as antimicrobial agents

(2010) Nikken Wiradharma et al.   BIOMATERIALS

Activity of Telavancin against Staphylococci and Enterococci Determined by MIC and Resistance Selection Studies

(2009) K. Kosowska-Shick et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES