Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria

A glycosylated cationic block poly(beta-peptide) reverses intrinsic antibiotic resistance in all ESKAPE Gram-negative bacteria

(2020) Zhangyong Si et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dilipid Ultrashort Tetrabasic Peptidomimetics Potentiate Novobiocin and Rifampicin Against Multidrug-Resistant Gram-Negative Bacteria

(2020) Danyel Ramirez et al.   ACS Infectious Diseases

A novel, rationally designed, hybrid antimicrobial peptide, inspired by cathelicidin and aurein, exhibits membrane-active mechanisms against Pseudomonas aeruginosa

(2020) Natthaporn Klubthawee et al.   Scientific Reports

Effect of N-methylated and fatty acid conjugation on analogs of antimicrobial peptide Anoplin

(2020) Tianqi Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities

(2019) Yuzhang Liu et al.   Drug Design Development and Therapy

Cationic antimicrobial peptides: alternatives and/or adjuvants to antibiotics active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa

(2019) Regina Geitani et al.   BMC MICROBIOLOGY

Design and synthesis of biocompatible, hemocompatible and highly selective antimicrobial cationic peptidopolysaccharides via click chemistry

(2019) Yun Chen et al.   BIOMACROMOLECULES

Rifampin resistance and its fitness cost in Riemerella anatipestifer

(2019) Jiakai Sun et al.   BMC MICROBIOLOGY

Liquid chromatography–tandem mass spectrometry based method development and validation of S016-1271 (LR8P), a novel cationic antimicrobial peptide for its application to pharmacokinetic studies

(2019) Santosh Kumar Puttrevu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Hydrophobic Control of the Bioactivity and Cytotoxicity of de Novo-Designed Antimicrobial Peptides

(2019) Haoning Gong et al.   ACS Applied Materials & Interfaces

The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1

(2019) Cibele Nicolaski Pedron et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties

(2019) Felicitas Vernen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

(2019) Rida Mourtada et al.   NATURE BIOTECHNOLOGY

The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities

(2019) Ganesan Rajasekaran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity

(2019) Chao Zhong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Functional Synergy Of Antimicrobial Peptides And Chlorhexidine Acetate Against Gram-Negative/Gram-Positive Bacteria And A Fungus In Vitro And In Vivo

(2019) Jie Zhu et al.   Infection and Drug Resistance

Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria

(2019) Chao Zhong et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Short Proline-Rich Lipopeptide Potentiates Minocycline and Rifampin against Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa

(2018) Ronald Domalaon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial and anti-inflammatory activities of chemokine CXCL14-derived antimicrobial peptide and its analogs

(2018) Ganesan Rajasekaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1

(2018) Na Dong et al.   Chemical Biology & Drug Design

Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering

(2018) Xiaoling Chen et al.   International Journal of Biological Sciences

Tryptophan-Rich and Proline-Rich Antimicrobial Peptides

(2018) Awdhesh Mishra et al.   MOLECULES

A D-enantiomer of the antimicrobial peptide GL13K evades antimicrobial resistance in the Gram positive bacteria Enterococcus faecalis and Streptococcus gordonii

(2018) Helmut Hirt et al.   PLoS One

Identification of novel antimicrobial peptide from Asian sea bass (Lates calcarifer) by in silico and activity characterization

(2018) Behrouz Taheri et al.   PLoS One

The potency of the broad spectrum bacteriocin, bactofencin A, against staphylococci is highly dependent on primary structure, N-terminal charge and disulphide formation

(2018) Paula M. O’ Connor et al.   Scientific Reports

Activity of a novel antimicrobial peptide against Pseudomonas aeruginosa biofilms

(2018) Trevor Beaudoin et al.   Scientific Reports

Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii

(2018) Yining Tan et al.   Toxins

Structural insight into the mechanism of action of antimicrobial peptide BMAP-28(1–18) and its analogue mutBMAP18

(2018) Nutan Agadi et al.   JOURNAL OF STRUCTURAL BIOLOGY

Intrinsic, adaptive and acquired antimicrobial resistance in Gram-negative bacteria

(2017) Mohsen Arzanlou et al.   Essays in Biochemistry

Design of novel antimicrobial peptide dimer analogues with enhanced antimicrobial activity in vitro and in vivo by intermolecular triazole bridge strategy

(2017) Beijun Liu et al.   PEPTIDES

Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria

(2017) Xiaozhe Wu et al.   Drug Design Development and Therapy

Structure–Activity and −Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1

(2017) Ingrid A. Edwards et al.   ACS Infectious Diseases

The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

(2017) Roberta J. Melander et al.   ACS Infectious Diseases

Polycarbonates with Potent and Selective Antimicrobial Activity toward Gram-Positive Bacteria

(2016) Alekhya Nimmagadda et al.   BIOMACROMOLECULES

A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes

(2016) Virender K. Sharma et al.   CHEMOSPHERE

Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

(2016) Gerard D. Wright   TRENDS IN MICROBIOLOGY

Design of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity

(2016) Shi-Kun Zhang et al.   Scientific Reports

Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different α-helical propensity

(2015) Xin Zhu et al.   Acta Biomaterialia

Rifampicin-resistance, rpoB polymorphism and RNA polymerase genetic engineering

(2015) Pietro Alifano et al.   JOURNAL OF BIOTECHNOLOGY

N-Lipidated Peptide Dimers: Effective Antibacterial Agents against Gram-Negative Pathogens through Lipopolysaccharide Permeabilization

(2015) Jun-Jie Koh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sensitization of Gram-negative bacteria to rifampin and OAK combinations

(2015) Joanna Jammal et al.   Scientific Reports

Update on the antibiotic resistance crisis

(2014) Gian Maria Rossolini et al.   CURRENT OPINION IN PHARMACOLOGY

Resistance to rifampicin: a review

(2014) Beth P Goldstein   JOURNAL OF ANTIBIOTICS

Antimicrobial activities and membrane-active mechanism of CPF-C1 against multidrug-resistant bacteria, a novel antimicrobial peptide derived from skin secretions of the tetraploid frogXenopus clivii

(2014) Junqiu Xie et al.   JOURNAL OF PEPTIDE SCIENCE

Design of imperfectly amphipathic α-helical antimicrobial peptides with enhanced cell selectivity

(2013) Xin Zhu et al.   Acta Biomaterialia

Effect of hydrophobic modifications in antimicrobial peptides

(2013) Artur Schmidtchen et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles

(2013) Zhan Yuin Ong et al.   BIOMATERIALS

Sensitization of gram-negative bacteria by targeting the membrane potential

(2013) Keren Goldberg et al.   FASEB JOURNAL

Intrinsic antibiotic resistance: Mechanisms, origins, challenges and solutions

(2013) Georgina Cox et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

De novo generation of short antimicrobial peptides with enhanced stability and cell specificity

(2013) H. Kim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Truncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus

(2013) Ming-Ching Lin et al.   PEPTIDES

Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides

(2012) Cristina Chamorro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antimicrobial HPA3NT3 peptide analogs: Placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action

(2012) Jong-Kook Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Adjuvant strategies for potentiation of antibiotics to overcome antimicrobial resistance

(2012) Michel Pieren et al.   CURRENT OPINION IN PHARMACOLOGY

Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta

(2011) Paolo Grieco et al.   JOURNAL OF PEPTIDE SCIENCE

Chain length dependence of antimicrobial peptide–fatty acid conjugate activity

(2009) Alexander F. Chu-Kung et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides

(2008) Susana Sanchez-Gomez et al.   BMC MICROBIOLOGY