Cross‐Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified β‐Hairpin Antimicrobial Amphiphiles

Antimicrobial host defence peptides: functions and clinical potential

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Rational Avoidance of Protease Cleavage Sites and Symmetrical End-Tagging Significantly Enhances the Stability and Therapeutic Potential of Antimicrobial Peptides

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Peptide Design Principles for Antimicrobial Applications

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Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria

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Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency

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Alternatives to Conventional Antibiotics in the Era of Antimicrobial Resistance

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Highly Stabilized α-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition

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Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism

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Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

(2019) Biswajit Mishra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Vast Structural Diversity of Antimicrobial Peptides

(2019) Johannes Koehbach et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Antimicrobial peptides with protease stability: progress and perspective

(2019) Changxuan Shao et al.   Future Medicinal Chemistry

Bioactivity and Bactericidal Mechanism of Histidine-Rich β-Hairpin Peptide Against Gram-Negative Bacteria

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Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

(2019) Rida Mourtada et al.   NATURE BIOTECHNOLOGY

Design of Heptad Repeat Amphiphiles Based on Database Filtering and Structure–Function Relationships to Combat Drug-Resistant Fungi and Biofilms

(2019) Peng Tan et al.   ACS Applied Materials & Interfaces

Multiple Strategy Optimization of Specifically Targeted Antimicrobial Peptide Based on Structure–Activity Relationships to Enhance Bactericidal Efficiency

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Central β-turn increases the cell selectivity of imperfectly amphipathic α-helical peptides

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The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

(2018) Anna de Breij et al.   Science Translational Medicine

Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era

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Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism

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Prediction of antibiotic resistance: time for a new preclinical paradigm?

(2017) Morten O. A. Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Short, multiple-stranded β-hairpin peptides have antimicrobial potency with high selectivity and salt resistance

(2016) Shuli Chou et al.   Acta Biomaterialia

Molecular mechanisms of membrane targeting antibiotics

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Hairpin structure stability plays a role in the activity of two antimicrobial peptides

(2016) Kalkena Sivanesam et al.   FEBS LETTERS

Contribution of Amphipathicity and Hydrophobicity to the Antimicrobial Activity and Cytotoxicity of β-Hairpin Peptides

(2016) Ingrid A. Edwards et al.   ACS Infectious Diseases

Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

(2016) Shu J. Lam et al.   Nature Microbiology

Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different α-helical propensity

(2015) Xin Zhu et al.   Acta Biomaterialia

LFP-20, a porcine lactoferrin peptide, ameliorates LPS-induced inflammation via the MyD88/NF-κB and MyD88/MAPK signaling pathways

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Unravelling of a mechanism of resistance to colistin inKlebsiella pneumoniaeusing atomic force microscopy

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The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

APD3: the antimicrobial peptide database as a tool for research and education

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Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials

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Antimicrobial potency and selectivity of simplified symmetric-end peptides

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pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37

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Design of imperfectly amphipathic α-helical antimicrobial peptides with enhanced cell selectivity

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Short Syntheticβ-Sheet Forming Peptide Amphiphiles as Broad Spectrum Antimicrobials with Antibiofilm and Endotoxin Neutralizing Capabilities

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Effect of hydrophobic modifications in antimicrobial peptides

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Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

(2013) Ashley L Hilchie et al.   Nature Chemical Biology

The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance

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Database screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300

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Rapid Discrimination of Gram-Positive and Gram-Negative Bacteria in Liquid Samples by Using NaOH-Sodium Dodecyl Sulfate Solution and Flow Cytometry

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Designing antimicrobial peptides: form follows function

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Comparing dendritic and self-assembly strategies to multivalency—RGD peptide–integrin interactions

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Inhibitory effects and mechanisms of physiological conditions on the activity of enantiomeric forms of an α-helical antibacterial peptide against bacteria

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Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity

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β-hairpin-forming peptides; models of early stages of protein folding

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Tryptophan residues: Scarce in proteins but strong stabilizers of β-hairpin peptides

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The structure of well-folded β-hairpin peptides promotes resistance to peptidase degradation

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Using Fluorous Amino Acids To Probe the Effects of Changing Hydrophobicity on the Physical and Biological Properties of the β-Hairpin Antimicrobial Peptide Protegrin-1†

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