Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

(2016) Yushu Dong et al.   JOURNAL OF PINEAL RESEARCH

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

(2016) Yan Zhou et al.   Molecular Neurodegeneration

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

(2015) Xian Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Negative regulation of the inflammasome: keeping inflammation under control

(2015) Gustavo Pedraza-Alva et al.   IMMUNOLOGICAL REVIEWS

Regulation of NOD-like receptors and inflammasome activation in cerebral endothelial cells

(2015) Péter Nagyőszi et al.   JOURNAL OF NEUROCHEMISTRY

The pathogenic role of the inflammasome in neurodegenerative diseases

(2015) Leslie C. Freeman et al.   JOURNAL OF NEUROCHEMISTRY

Recombinant adenovirus encoding NLRP3 RNAi attenuate inflammation and brain injury after intracerebral hemorrhage

(2015) Bangqing Yuan et al.   JOURNAL OF NEUROIMMUNOLOGY

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

(2015) Liang Feng et al.   Journal of Neuroinflammation

NALP3 inflammasome activation in protein misfolding diseases

(2015) Fushan Shi et al.   LIFE SCIENCES

MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage

(2015) Zhao Yang et al.   MOLECULAR IMMUNOLOGY

Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage

(2015) Jianru Li et al.   MOLECULAR NEUROBIOLOGY

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome

(2015) Anwen Shao et al.   MOLECULAR NEUROBIOLOGY

Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain

(2015) Leoni Lammerding et al.   NEUROENDOCRINOLOGY

Oxygen-glucose deprivation inducing B1 RNA inhibits neuronal cells metabolic activity by NLRP3 and associated proinflammatory cytokines production

(2015) Li Wang et al.   NEUROSCIENCE LETTERS

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

Upregulation of NLRP3 Inflammasome in the Tears and Ocular Surface of Dry Eye Patients

(2015) Liangliang Niu et al.   PLoS One

Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats

(2015) Jing Zhao et al.   PLoS One

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

(2015) Ying Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Rethinking the Roles of Inflammation in the Intracerebral Hemorrhage

(2015) Xiao-Yi Xiong et al.   Translational Stroke Research

Aneurysmal Subarachnoid Hemorrhage—Status Quo and Perspective

(2015) Nima Etminan   Translational Stroke Research

Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke

(2015) Qasim Alhadidi et al.   Translational Stroke Research

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Intermittent fasting attenuates inflammasome activity in ischemic stroke

(2014) David Yang-Wei Fann et al.   EXPERIMENTAL NEUROLOGY

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

(2014) Evan A. Bordt et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

(2014) Masahiro Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus

(2014) Xiang-Fei Meng et al.   Journal of Neuroinflammation

Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

(2014) Tauheed Ishrat et al.   MOLECULAR NEUROBIOLOGY

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

(2014) Xiaqiong Wang et al.   NATURE IMMUNOLOGY

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Inflammasome: Cancer's friend or foe?

(2014) Michela Terlizzi et al.   PHARMACOLOGY & THERAPEUTICS

Aberrant Expression of Interleukin-1β and Inflammasome Activation in Human Malignant Gliomas

(2014) Leonid Tarassishin et al.   PLoS One

Expression pattern of NLRP3 and its related cytokines in the lung and brain of avian influenza virus H9N2 infected BALB/c mice

(2014) Meng Yu et al.   Virology Journal

Molecular and Cellular Immune Responses to Ischemic Brain Injury

(2014) Hilary A. Seifert et al.   Translational Stroke Research

Intracerebral Hemorrhage: A Multimodality Approach to Improving Outcome

(2014) Aditya S. Pandey et al.   Translational Stroke Research

What is Early Brain Injury?

(2014) Hidenori Suzuki   Translational Stroke Research

An Update on Inflammation in the Acute Phase of Intracerebral Hemorrhage

(2014) Sheng Chen et al.   Translational Stroke Research

Subarachnoid Hemorrhage: a Review of Experimental Studies on the Microcirculation and the Neurovascular Unit

(2014) Michael K. Tso et al.   Translational Stroke Research

Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome

(2014) Deborah D. Crane et al.   Frontiers in Microbiology

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage

(2013) Qingyi Ma et al.   ANNALS OF NEUROLOGY

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

(2013) Islam N. Mohamed et al.   DIABETOLOGIA

NADPH oxidase derived reactive oxygen species are involved in human neutrophil IL-1β secretion but not in inflammasome activation

(2013) María Laura Gabelloni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasome activation restrictsLegionella pneumophilareplication in primary microglial cells through flagellin detection

(2013) Yvan Jamilloux et al.   GLIA

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

(2013) Robert van der Burgh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

(2013) S. Park et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor alpha antagonism improves neurological recovery in murine intracerebral hemorrhage

(2013) Beilei Lei et al.   Journal of Neuroinflammation

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation

(2013) Ming Lu et al.   NEUROBIOLOGY OF AGING

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

TLR-induced PAI-2 expression suppresses IL-1  processing via increasing autophagy and NLRP3 degradation

(2013) S.-Y. Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controversies and evolving new mechanisms in subarachnoid hemorrhage

(2013) Sheng Chen et al.   PROGRESS IN NEUROBIOLOGY

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Pathobiology of injury after stroke: the neurovascular unit and beyond

(2012) Ulrich Dirnagl   Annals of the New York Academy of Sciences

NLRP3 Suppresses NK Cell-Mediated Responses to Carcinogen-Induced Tumors and Metastases

(2012) M. T. Chow et al.   CANCER RESEARCH

Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma

(2012) Lih-Chyang Chen et al.   EMBO Molecular Medicine

Transition of research focus from vasospasm to early brain injury after subarachnoid hemorrhage

(2012) Basak Caner et al.   JOURNAL OF NEUROCHEMISTRY

Anti-Viral and Anti-Inflammatory Mechanisms of the Innate Immune Transcription Factor Interferon Regulatory Factor 3: Relevance to Human CNS Diseases

(2012) Leonid Tarassishin et al.   Journal of Neuroimmune Pharmacology

Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome

(2012) Stephanie Adamczak et al.   JOURNAL OF NEUROSURGERY

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

(2012) Richard F Keep et al.   LANCET NEUROLOGY

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

Lithium pretreatment reduces brain injury after intracerebral hemorrhage in rats

(2012) K Kang et al.   NEUROLOGICAL RESEARCH

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The importance of early brain injury after subarachnoid hemorrhage

(2012) Fatima A. Sehba et al.   PROGRESS IN NEUROBIOLOGY

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

The Neuroprotective Effect of a Specific P2X7 Receptor Antagonist Derives from its Ability to Inhibit Assembly of the NLRP3 Inflammasome in Glial Cells

(2011) Niamh Murphy et al.   BRAIN PATHOLOGY

Inflammasome activation via intracellular NLRs triggered by bacterial infection

(2011) Yukiko Koizumi et al.   CELLULAR MICROBIOLOGY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release

(2011) Tobias Hoegen et al.   JOURNAL OF IMMUNOLOGY

Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia

(2011) Richa Hanamsagar et al.   JOURNAL OF NEUROCHEMISTRY

Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats

(2011) Jin-bing Zhao et al.   NEUROSCIENCE LETTERS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The role of microglia in central nervous system immunity and glioma immunology

(2009) Isaac Yang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Antioxidant properties of MitoTEMPOL and its hydroxylamine

(2008) Jan Trnka et al.   FREE RADICAL RESEARCH

Inflammasomes: guardians of cytosolic sanctity

(2008) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

(2007) Johanna Ojala et al.   NEUROBIOLOGY OF AGING