Comprehensive analysis of kinase inhibitor selectivity

High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors

(2011) Chandrasekhar V. Miduturu et al.   CHEMISTRY & BIOLOGY

Navigating the kinome

(2011) James T Metz et al.   Nature Chemical Biology

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

(2011) Xianming Deng et al.   Nature Chemical Biology

Activation State-Dependent Binding of Small Molecule Kinase Inhibitors: Structural Insights from Biochemistry

(2010) Lisa M. Wodicka et al.   CHEMISTRY & BIOLOGY

Kinase inhibition-related adverse events predicted from in vitro kinome and clinical trial data

(2010) Xinan Yang et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Trends in Kinase Selectivity: Insights for Target Class-Focused Library Screening

(2010) Shana L. Posy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorophore Labeling of the Glycine-Rich Loop as a Method of Identifying Inhibitors That Bind to Active and Inactive Kinase Conformations†

(2010) Jeffrey R. Simard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

(2010) Nicholas Kwiatkowski et al.   Nature Chemical Biology

The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro

(2010) Brian B. Hasinoff et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis

(2009) Danzhi Huang et al.   BIOINFORMATICS

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

(2009) P. P. Zarrinkar et al.   BLOOD

SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo

(2009) S. G. Buchanan et al.   MOLECULAR CANCER THERAPEUTICS

Identification of a Kinase Profile that Predicts Chromosome Damage Induced by Small Molecule Kinase Inhibitors

(2009) Andrew J. Olaharski et al.   PLoS Computational Biology

Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery

(2008) Paul Bamborough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

(2008) L L Remsing Rix et al.   LEUKEMIA

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

High-throughput kinase profiling as a platform for drug discovery

(2008) David M. Goldstein et al.   NATURE REVIEWS DRUG DISCOVERY