Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

Applications of metabolomics to study cancer metabolism

(2018) Akash K. Kaushik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

(2018) Elizabeth A. McMillan et al.   CELL

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches

(2018) Jelle J. F. Sleeboom et al.   Disease Models & Mechanisms

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

(2018) Denise R. Minton et al.   MOLECULAR CELL

Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis

(2018) Dongxin Zhao et al.   MOLECULAR CELL

Metabolomics activity screening for identifying metabolites that modulate phenotype

(2018) Carlos Guijas et al.   NATURE BIOTECHNOLOGY

Data processing, multi-omic pathway mapping, and metabolite activity analysis using XCMS Online

(2018) Erica M Forsberg et al.   Nature Protocols

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Cancer metabolism gets physical

(2018) Peter DelNero et al.   Science Translational Medicine

Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy

(2018) Adam J. Wolpaw et al.   TRENDS IN CELL BIOLOGY

Metabolic Hallmarks of Metastasis Formation

(2018) Ilaria Elia et al.   TRENDS IN CELL BIOLOGY

A Landscape of Metabolic Variation across Tumor Types

(2018) Ed Reznik et al.   Cell Systems

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics

(2017) Alexandra Naba et al.   JOURNAL OF PROTEOME RESEARCH

Understanding metabolism with flux analysis: From theory to application

(2017) Ziwei Dai et al.   METABOLIC ENGINEERING

CRISPR/Cas9 screening using unique molecular identifiers

(2017) Bernhard Schmierer et al.   Molecular Systems Biology

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

(2017) Jiyeon Kim et al.   NATURE

Nutrient acquisition strategies of mammalian cells

(2017) Wilhelm Palm et al.   NATURE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screens

(2017) Georg Michlits et al.   NATURE METHODS

Am I ready for CRISPR? A user's guide to genetic screens

(2017) John G. Doench   NATURE REVIEWS GENETICS

Metabolic origins of spatial organization in the tumor microenvironment

(2017) Carlos Carmona-Fontaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

(2017) Jessica B. Spinelli et al.   SCIENCE

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Starved epithelial cells uptake extracellular matrix for survival

(2017) Taru Muranen et al.   Nature Communications

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

(2017) Douglas E. Biancur et al.   Nature Communications

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers

(2017) Oliver M.T. Pearce et al.   Cancer Discovery

Multiplex three-dimensional optical mapping of tumor immune microenvironment

(2017) Steve Seung-Young Lee et al.   Scientific Reports

Entosis Is Induced by Glucose Starvation

(2017) Jens C. Hamann et al.   Cell Reports

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

(2017) Alexander Muir et al.   eLife

mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells

(2016) Raju V. Pusapati et al.   CANCER CELL

Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis

(2016) Camille Lehuédé et al.   CANCER RESEARCH

Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

(2016) Weimin Wang et al.   CELL

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

(2016) Dan Y. Gui et al.   Cell Metabolism

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

(2016) Lifeng Yang et al.   Cell Metabolism

Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation

(2016) Cyril Corbet et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

(2016) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

(2016) Aaron Boudreau et al.   Nature Chemical Biology

Erratum: NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2016) Gina M DeNicola et al.   NATURE GENETICS

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

(2016) Shawn M Davidson et al.   NATURE MEDICINE

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

(2016) Stefan Christen et al.   Cell Reports

Spatial Heterogeneity in the Tumor Microenvironment

(2016) Yinyin Yuan   Cold Spring Harbor Perspectives in Medicine

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Metformin in Cancer Treatment and Prevention

(2015) Daniel R. Morales et al.   Annual Review of Medicine

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges

(2015) Chi-Ping Day et al.   CELL

Metabolic Dependencies in RAS-Driven Cancers

(2015) A. C. Kimmelman   CLINICAL CANCER RESEARCH

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

How to measure metabolic fluxes: a taxonomic guide for 13 C fluxomics

(2015) Sebastian Niedenführ et al.   CURRENT OPINION IN BIOTECHNOLOGY

Tumor mechanics and metabolic dysfunction

(2015) Jason C. Tung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

Mapping spatial heterogeneity in the tumor microenvironment: a new era for digital pathology

(2015) Andreas Heindl et al.   LABORATORY INVESTIGATION

MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice

(2015) Michaela Aichler et al.   LABORATORY INVESTIGATION

13 C-metabolic flux analysis of co-cultures: A novel approach

(2015) Nikodimos A. Gebreselassie et al.   METABOLIC ENGINEERING

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

High-throughput functional genomics using CRISPR–Cas9

(2015) Ophir Shalem et al.   NATURE REVIEWS GENETICS

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

(2015) Anneleen Daemen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate

(2015) Melissa M. Keenan et al.   PLoS Genetics

Recent advances in sample preparation techniques to overcome difficulties encountered during quantitative analysis of small molecules from biofluids using LC-MS/MS

(2014) Caroline Bylda et al.   ANALYST

Mass Spectrometry Imaging of Biomolecular Information

(2014) Bernhard Spengler   ANALYTICAL CHEMISTRY

Targeting Metabolic Changes in Cancer: Novel Therapeutic Approaches

(2014) Ekaterina Bobrovnikova-Marjon et al.   Annual Review of Medicine

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

(2014) Yoav D. Shaul et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

In vivo shRNA screens in solid tumors

(2014) Gaetano Gargiulo et al.   Nature Protocols

Mesenchymal Phenotype Predisposes Lung Cancer Cells to Impaired Proliferation and Redox Stress in Response to Glutaminase Inhibition

(2014) Danielle B. Ulanet et al.   PLoS One

Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks

(2014) Achuthanunni Chokkathukalam et al.   Bioanalysis

A Peptide-Based Method for 13C Metabolic Flux Analysis in Microbial Communities

(2014) Amit Ghosh et al.   PLoS Computational Biology

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR regulates phagosome and entotic vacuole fission

(2013) Matej Krajcovic et al.   MOLECULAR BIOLOGY OF THE CELL

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

(2012) Helge Wiig et al.   PHYSIOLOGICAL REVIEWS

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Subpopulation-Specific Metabolic Pathway Usage in Mixed Cultures as Revealed by Reporter Protein-Based13C Analysis

(2011) Martin Rühl et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

The Human Serum Metabolome

(2011) Nikolaos Psychogios et al.   PLoS One

An overview of matrix effects in liquid chromatography-mass spectrometry

(2010) Helga Trufelli et al.   MASS SPECTROMETRY REVIEWS

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Isotopomer Distributions in Amino Acids from a Highly Expressed Protein as a Proxy for Those from Total Protein

(2008) Afshan S. Shaikh et al.   ANALYTICAL CHEMISTRY

The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers

(2008) Julia Ling-Yu Chen et al.   PLoS Genetics