Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

Bromodomain and hedgehog pathway targets in small cell lung cancer

(2016) Gurmeet Kaur et al.   CANCER LETTERS

Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility

(2016) Sarah K. Denny et al.   CELL

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Vasculogenic mimicry in small cell lung cancer

(2016) Stuart C. Williamson et al.   Nature Communications

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer

(2016) Nadine S. Jahchan et al.   Cell Reports

Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

(2015) W.-C. Yen et al.   CLINICAL CANCER RESEARCH

Small Cell Lung Cancer: Will Recent Progress Lead to Improved Outcomes?

(2015) M. C. Pietanza et al.   CLINICAL CANCER RESEARCH

Notch signaling regulates gastric antral LGR5 stem cell function

(2015) E. S. Demitrack et al.   EMBO JOURNAL

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Cisplatin combined with irinotecan or etoposide for untreated extensive-stage small cell lung cancer: A multicenter randomized controlled clinical trial

(2015) Yuankai Shi et al.   Thoracic Cancer

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal

(2013) Yanyan Zheng et al.   CANCER CELL

Notch signaling at a glance

(2013) K. Hori et al.   JOURNAL OF CELL SCIENCE

A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

(2013) N. S. Jahchan et al.   Cancer Discovery

Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells

(2012) M. Morimoto et al.   DEVELOPMENT

A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer

(2011) Joaquim Calbo et al.   CANCER CELL

Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

(2011) Kate D. Sutherland et al.   CANCER CELL

A crucial requirement for Hedgehog signaling in small cell lung cancer

(2011) Kwon-Sik Park et al.   NATURE MEDICINE

OASIS: Online Application for the Survival Analysis of Lifespan Assays Performed in Aging Research

(2011) Jae-Seong Yang et al.   PLoS One

Notch Lineages and Activity in Intestinal Stem Cells Determined by a New Set of Knock-In Mice

(2011) Silvia Fre et al.   PLoS One

Loss of p130 Accelerates Tumor Development in a Mouse Model for Human Small-Cell Lung Carcinoma

(2010) B. E. Schaffer et al.   CANCER RESEARCH

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Achaete-Scute Complex Homologue 1 Regulates Tumor-Initiating Capacity in Human Small Cell Lung Cancer

(2009) T. Jiang et al.   CANCER RESEARCH

Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

(2009) P.-N. Tsao et al.   DEVELOPMENT

The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells

(2009) T. Kobayashi et al.   GENES & DEVELOPMENT

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Regulated Expression of a Tumor-Associated Antigen Reveals Multiple Levels of T-Cell Tolerance in a Mouse Model of Lung Cancer

(2008) A. F. Cheung et al.   CANCER RESEARCH

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

(2008) Orbicia Riccio et al.   EMBO REPORTS

The Human Combinatorial Antibody Library HuCAL GOLD Combines Diversification of All Six CDRs According to the Natural Immune System with a Novel Display Method for Efficient Selection of High-Affinity Antibodies

(2008) Christine Rothe et al.   JOURNAL OF MOLECULAR BIOLOGY