The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis

Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition

(2019) Arnaud Augert et al.   Science Signaling

VIPER: Visualization Pipeline for RNA-seq, a Snakemake workflow for efficient and complete RNA-seq analysis

(2018) MacIntosh Cornwell et al.   BMC BIOINFORMATICS

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation

(2018) Ikuo K. Suzuki et al.   CELL

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

(2018) Ian T. Fiddes et al.   CELL

Autochthonous tumors driven byRb1loss have an ongoing requirement for the RBP2 histone demethylase

(2018) Samuel K. McBrayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

(2018) Leora Horn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage

(2018) Jung Wook Park et al.   SCIENCE

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

(2017) Jing Shan Lim et al.   NATURE

Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens

(2017) Xuefeng Liu et al.   Nature Protocols

OUP accepted manuscript

(2017)   NUCLEIC ACIDS RESEARCH

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer

(2017) Ping Mu et al.   SCIENCE

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

(2017) Sheng Yu Ku et al.   SCIENCE

Small Cell Lung Cancer

(2017) Gregory P. Kalemkerian et al.   Journal of the National Comprehensive Cancer Network

RB1: a prototype tumor suppressor and an enigma

(2016) Nicholas J. Dyson   GENES & DEVELOPMENT

Structural analysis of human KDM5B guides histone demethylase inhibitor development

(2016) Catrine Johansson et al.   Nature Chemical Biology

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

(2016) Mark D. Borromeo et al.   Cell Reports

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

(2015) Helai P. Mohammad et al.   CANCER CELL

Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells

(2015) Renáta Váraljai et al.   GENES & DEVELOPMENT

The Comparative Pathology of Genetically Engineered Mouse Models for Neuroendocrine Carcinomas of the Lung

(2015) Adi F. Gazdar et al.   Journal of Thoracic Oncology

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

(2015) Matthew J. Niederst et al.   Nature Communications

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

(2014) Camilla L. Christensen et al.   CANCER CELL

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

(2014) A. Augustyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

(2014) Soham Chanda et al.   Stem Cell Reports

Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma

(2013) H.-L. Tan et al.   CLINICAL CANCER RESEARCH

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

(2012) Warren A. Whyte et al.   NATURE

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

(2012) Charles M Rudin et al.   NATURE GENETICS

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

(2012) Martin Peifer et al.   NATURE GENETICS

Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation

(2012) M. L. Beshiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer

(2011) Joaquim Calbo et al.   CANCER CELL

Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

(2011) Kate D. Sutherland et al.   CANCER CELL

Functional antagonism between histone H3K4 demethylases in vivo

(2011) L. Di Stefano et al.   GENES & DEVELOPMENT

A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development

(2011) Peter Mulligan et al.   MOLECULAR CELL

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

(2011) W. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast and accurate long-read alignment with Burrows–Wheeler transform

(2010) Heng Li et al.   BIOINFORMATICS

Loss of p130 Accelerates Tumor Development in a Mouse Model for Human Small-Cell Lung Carcinoma

(2010) B. E. Schaffer et al.   CANCER RESEARCH

Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex

(2010) R. Liefke et al.   GENES & DEVELOPMENT

Histone demethylases in development and disease

(2010) Marianne Terndrup Pedersen et al.   TRENDS IN CELL BIOLOGY

Histone Chaperones ASF1 and NAP1 Differentially Modulate Removal of Active Histone Marks by LID-RPD3 Complexes during NOTCH Silencing

(2009) Yuri M. Moshkin et al.   MOLECULAR CELL

Neurod1 is essential for the survival and maturation of adult-born neurons

(2009) Zhengliang Gao et al.   NATURE NEUROSCIENCE

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

(2009) Michel DuPage et al.   Nature Protocols

Design and analysis of ChIP-seq experiments for DNA-binding proteins

(2008) Peter V Kharchenko et al.   NATURE BIOTECHNOLOGY