Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores

Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

(2021) Robert O. Hughes et al.   Cell Reports

Endoplasmic Reticulum Interaction Supports Energy Production and Redox Homeostasis in Mitochondria Released from Astrocytes

(2021) Ji-Hyun Park et al.   Translational Stroke Research

Jupiter Microtubule Associated Homolog 2 is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Binding Protein Required for NAADP-Evoked Intracellular Calcium Release

(2021) Gihan S. Gunaratne et al.   BIOPHYSICAL JOURNAL

Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination

(2021) Sergio Navarro-Serna et al.   CRISPR Journal

HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation

(2021) Hannes G. Roggenkamp et al.   Science Signaling

Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

(2021) Soojin Kim et al.   Nature Communications

Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

(2021) Ponsawan Netcharoensirisuk et al.   Scientific Reports

Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS

(2021) Travis E. Faust et al.   NATURE REVIEWS NEUROSCIENCE

NAADP: From Discovery to Mechanism

(2021) Timothy F. Walseth et al.   Frontiers in Immunology

NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells

(2021) Sharon Negri et al.   CELL CALCIUM

Voltage-gating and cytosolic Ca2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1

(2021) Fan Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation

(2021) Feng Gu et al.   Science Signaling

cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons

(2020) Yo Sasaki et al.   EXPERIMENTAL NEUROLOGY

Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis

(2020) Yeonsoo Joe et al.   Cell Reports

CD38 in Neurodegeneration and Neuroinflammation

(2020) Serge Guerreiro et al.   Cells

Modulation of the excitability of stellate neurons in the ventral cochlear nucleus of mice by TRPM2 channels

(2020) Ramazan Bal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

(2020) Susanne Gerndt et al.   eLife

Lysosomal Biology and Function: Modern View of Cellular Debris Bin

(2020) Purvi C. Trivedi et al.   Cells

NAADP ‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca 2+ nanodomains, calcineurin and dynamin

(2020) Lianne C Davis et al.   EMBO JOURNAL

Nicotinic acid adenine dinucleotide phosphate activates two‐pore channel TPC1 to mediate lysosomal Ca 2+ release in endothelial colony‐forming cells

(2020) Francesco Moccia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondria-lysosome contacts regulate mitochondrial Ca2+dynamics via lysosomal TRPML1

(2020) Wesley Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity

(2020) Elisabeth Arlt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2-Related Parkinson’s Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis

(2020) Pilar Rivero-Ríos et al.   Frontiers in Neuroscience

Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons

(2020) Julia Hermann et al.   Frontiers in Cell and Developmental Biology

Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory

(2020) Robert Theodor Mallmann et al.   BEHAVIOR GENETICS

The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1

(2020) Yuefeng Jiang et al.   NATURE

Loss of Two-Pore Channel 2 (TPC2) Expression Increases the Metastatic Traits of Melanoma Cells by a Mechanism Involving the Hippo Signalling Pathway and Store-Operated Calcium Entry

(2020) Antonella D’Amore et al.   Cancers

The axonal endolysosomal and autophagic systems

(2020) Marijn Kuijpers et al.   JOURNAL OF NEUROCHEMISTRY

Lysosomal dysfunction in proteinopathic neurodegenerative disorders: possible therapeutic roles of cAMP and zinc

(2019) Jae-Young Koh et al.   Molecular Brain

Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis

(2019) Yvette C. Wong et al.   TRENDS IN CELL BIOLOGY

A multiscale analysis in CD38−/− mice unveils major prefrontal cortex dysfunctions

(2019) Lora L. Martucci et al.   FASEB JOURNAL

Endothelial NMDA receptors mediate activity-dependent brain hemodynamic responses in mice

(2019) Adam D. Hogan-Cann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histamine induces intracellular Ca 2+ oscillations and nitric oxide release in endothelial cells from brain microvascular circulation

(2019) Roberto Berra‐Romani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer

(2019) Longfei Gao et al.   Frontiers in Cellular Neuroscience

NAADP Receptors

(2019) Antony Galione   Cold Spring Harbor Perspectives in Biology

Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation

(2019) Sarah E. Webb et al.   Cold Spring Harbor Perspectives in Biology

Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity

(2019) Tamar Farfel-Becker et al.   Cell Reports

Group 1 metabotropic glutamate receptors trigger glutamate-induced intracellular Ca2+ signals and nitric oxide release in human brain microvascular endothelial cells

(2019) Sharon Negri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells

(2019) Timnit Yosef Asfaha et al.   CELL CALCIUM

Resolving the topological enigma in Ca2+-signaling by cyclic ADP-ribose and NAADP

(2019) Hon Cheung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

(2019) D. Höglinger et al.   Nature Communications

Calcium Dyshomeostasis and Lysosomal Ca2+ Dysfunction in Amyotrophic Lateral Sclerosis

(2019) Tedeschi et al.   Cells

Does lysosomal rupture evoke Ca2+ release? A question of pores and stores

(2019) Anthony J. Morgan et al.   CELL CALCIUM

Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels

(2019) Xiaoli Zhang et al.   eLife

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

(2019) Haruhiro Higashida et al.   Cells

Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration

(2018) Mariana Pehar et al.   ANTIOXIDANTS & REDOX SIGNALING

TPC2-mediated Ca 2+ signaling is required for the establishment of synchronized activity in developing zebrafish primary motor neurons

(2018) Jeffrey J. Kelu et al.   DEVELOPMENTAL BIOLOGY

A phylogenetic view of the leukocyte ectonucleotidases

(2018) Enza Ferrero et al.   IMMUNOLOGY LETTERS

The Role of Endothelial Ca2+ Signaling in Neurovascular Coupling: A View from the Lumen

(2018) Germano Guerra et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD38 produces nicotinic acid adenosine dinucleotide phosphate in the lysosome

(2018) Cheng Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus

(2018) Thom P. Nelissen et al.   NEUROSCIENCE

mTORC1 controls lysosomal Ca2+release through the two-pore channel TPC2

(2018) Oluseye A. Ogunbayo et al.   Science Signaling

mTORC1 controls lysosomal Ca2+release through the two-pore channel TPC2

(2018) Oluseye A. Ogunbayo et al.   Science Signaling

Muscarinic M5 receptors trigger acetylcholine-induced Ca2+ signals and nitric oxide release in human brain microvascular endothelial cells

(2018) Estella Zuccolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A role for autophagy in Huntington's disease

(2018) Katherine R. Croce et al.   NEUROBIOLOGY OF DISEASE

Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers

(2018) Christopher J. Penny et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

5-Azido-8-ethynyl-NAADP: A bifunctional, clickable photoaffinity probe for the identification of NAADP receptors

(2018) Gihan S. Gunaratne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos

(2018) Jeffrey J. Kelu et al.   DEVELOPMENTAL BIOLOGY

Glutamate triggers intracellular Ca2+ oscillations and nitric oxide release by inducing NAADP- and InsP3 -dependent Ca2+ release in mouse brain endothelial cells

(2018) Estella Zuccolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling

(2018) William J. Foster et al.   Science Signaling

IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes

(2018) Peace Atakpa et al.   Cell Reports

CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously

(2017) Tsuyoshi Hattori et al.   GLIA

Synthesis of the Ca 2+ -mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling

(2017) Wee K. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-dependent trafficking of lysosomes in dendrites and dendritic spines

(2017) Marisa S. Goo et al.   JOURNAL OF CELL BIOLOGY

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

(2017) Thomas A Longden et al.   NATURE NEUROSCIENCE

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels

(2017) Jun Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-permeable organic fluorescent probes for live-cell long-term super-resolution imaging reveal lysosome-mitochondrion interactions

(2017) Yubing Han et al.   Nature Communications

TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry

(2017) Luigi Sbano et al.   Scientific Reports

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart

(2017) Daniel Aston et al.   Scientific Reports

The human two-pore channel 1 is modulated by cytosolic and luminal calcium

(2017) Laura Lagostena et al.   Scientific Reports

An Endosomal NAADP-Sensitive Two-Pore Ca 2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

(2017) Bethan S. Kilpatrick et al.   Cell Reports

Noradrenergic Modulation of Cognition in Health and Disease

(2017) Olga Borodovitsyna et al.   NEURAL PLASTICITY

Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes

(2017) Fuminori Tsuruta et al.   Jove-Journal of Visualized Experiments

Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis

(2017) Irene Pafumi et al.   Scientific Reports

Endoplasmic reticulum and lysosomal Ca2+ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts

(2016) Bethan S. Kilpatrick et al.   CELL CALCIUM

Ca2+/H+exchange by acidic organelles regulates cell migration in vivo

(2016) Manuela Melchionda et al.   JOURNAL OF CELL BIOLOGY

A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair

(2016) Marisa Encarnação et al.   JOURNAL OF CELL BIOLOGY

Endolysosomal two-pore channels regulate autophagy in cardiomyocytes

(2016) Vanessa García-Rúa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

SARM1-specific motifs in the TIR domain enable NAD+loss and regulate injury-induced SARM1 activation

(2016) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate induces autophagy via the two-pore channels in neural cells

(2016) Gustavo J. S. Pereira et al.   Oncotarget

Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology

(2016) Claire Shuk-Kwan Lee et al.   Scientific Reports

Impaired learning and memory in CD38 null mutant mice

(2016) Somi Kim et al.   Molecular Brain

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes

(2016) Abigail G Garrity et al.   eLife

Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease

(2015) M. Victoria Puig et al.   ACS Chemical Neuroscience

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Release of calcium from endolysosomes increases calcium influx through N-type calcium channels: Evidence for acidic store-operated calcium entry in neurons

(2015) Liang Hui et al.   CELL CALCIUM

A novel Ca2+-mediated cross-talk between endoplasmic reticulum and acidic organelles: Implications for NAADP-dependent Ca2+ signalling

(2015) Virginia Ronco et al.   CELL CALCIUM

A primer of NAADP-mediated Ca2+ signalling: From sea urchin eggs to mammalian cells

(2015) Antony Galione   CELL CALCIUM

Coupling acidic organelles with the ER through Ca2+ microdomains at membrane contact sites

(2015) Christopher J. Penny et al.   CELL CALCIUM

Evolution of acidic Ca2+ stores and their resident Ca2+-permeable channels

(2015) Sandip Patel et al.   CELL CALCIUM

Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

(2015) M. Ruas et al.   EMBO JOURNAL

Two-Pore Channel 2 activity is required for slow muscle cell-generated Ca2+ signaling during myogenesis in intact zebrafish

(2015) Jeffrey J. Kelu et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart

(2015) Rebecca A. Capel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells

(2015) Abdelilah Arredouani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome dynamics in neurodegeneration at a glance

(2015) Y. C. Wong et al.   JOURNAL OF CELL SCIENCE

Ion channel networks in the control of cerebral blood flow

(2015) Thomas A Longden et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate

(2015) Balázs Tóth et al.   JOURNAL OF GENERAL PHYSIOLOGY

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

(2015) Curt D. Haffner et al.   JOURNAL OF MEDICINAL CHEMISTRY

TPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release

(2015) Andrea L. Ambrosio et al.   MOLECULAR BIOLOGY OF THE CELL

PIKfyve mediates the motility of late endosomes and lysosomes in neuronal dendrites

(2015) Fuminori Tsuruta et al.   NEUROSCIENCE LETTERS

Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

(2015) Swetha Gowrishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Head circumference and brain size in autism spectrum disorder: A systematic review and meta-analysis

(2015) Roberto Sacco et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Frontrunners of T cell activation: Initial, localized Ca2+signals mediated by NAADP and the type 1 ryanodine receptor

(2015) Insa M. A. Wolf et al.   Science Signaling

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

CD38 Is Required for Neural Differentiation of Mouse Embryonic Stem Cells by Modulating Reactive Oxygen Species

(2015) Wenjie Wei et al.   STEM CELLS

Dendritic function in vivo

(2015) Christine Grienberger et al.   TRENDS IN NEUROSCIENCES

Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca 2+ Influx but Only Modestly Influenced by Mitochondria

(2015) Andrea Loreto et al.   Cell Reports

Frontrunners of T cell activation: Initial, localized Ca2+signals mediated by NAADP and the type 1 ryanodine receptor

(2015) Insa M. A. Wolf et al.   Science Signaling

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

(2014) A. Jha et al.   EMBO JOURNAL

The ADP-ribosyl cyclases - the current evolutionary state of the ARCs

(2014) Enza et al.   Frontiers in Bioscience-Landmark

Basal CD38/cyclic ADP-ribose-dependent signaling mediates ATP release and survival of microglia by modulating connexin 43 hemichannels

(2014) Yingxin Ma et al.   GLIA

Inhibition of glioma progression by a newly discovered CD38 inhibitor

(2014) Eran Blacher et al.   INTERNATIONAL JOURNAL OF CANCER

Lysosomal Two-pore Channel Subtype 2 (TPC2) Regulates Skeletal Muscle Autophagic Signaling

(2014) Pei-Hui Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The vacuolar-type H+-ATPase at a glance - more than a proton pump

(2014) M. E. Maxson et al.   JOURNAL OF CELL SCIENCE

TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2

(2014) M. Ruas et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction

(2014) Brett A. Simms et al.   NEURON

Rapid Recycling of Ca2+ between IP3-Sensitive Stores and Lysosomes

(2014) Cristina I. López Sanjurjo et al.   PLoS One

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling

(2014) A. Favia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels

(2014) T. Rahman et al.   Science Signaling

Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+

(2014) S. J. Pitt et al.   Science Signaling

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability

(2014) Chunlei Cang et al.   Nature Communications

Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

(2014) Olga Lopatina et al.   Frontiers in Behavioral Neuroscience

Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression

(2014) Paul R. Albert et al.   Frontiers in Behavioral Neuroscience

Two-pore channels (TPCs): Current controversies

(2013) Anthony J. Morgan et al.   BIOESSAYS

Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence

(2013) Nady Braidy et al.   BIOGERONTOLOGY

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

(2013) Mohammad Samie et al.   DEVELOPMENTAL CELL

Dopamine receptor D2 deficiency reduces mouse pup ultrasonic vocalizations and maternal responsiveness

(2013) T. Curry et al.   GENES BRAIN AND BEHAVIOR

Autocrine/Paracrine Function of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) for Glucose Homeostasis in Pancreatic β-Cells and Adipocytes

(2013) Kwang-Hyun Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bidirectional Ca2+signaling occurs between the endoplasmic reticulum and acidic organelles

(2013) Anthony J. Morgan et al.   JOURNAL OF CELL BIOLOGY

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature

(2013) Jonathan R. Friedman et al.   MOLECULAR BIOLOGY OF THE CELL

Triggering of Ca2+signals by NAADP-gated two-pore channels: a role for membrane contact sites?

(2012) Sandip Patel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Two-pore channel 2 (TPC2) modulates store-operated Ca2+ entry

(2012) José J. López et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: Implications for lysosomal function

(2012) Kara M Neely Kayala et al.   BRAIN RESEARCH

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing

(2012) Lianne C. Davis et al.   CURRENT BIOLOGY

Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) as Messengers for Calcium Mobilization

(2012) Hon Cheung Lee   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1

(2012) Volodymyr Rybalchenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct mobilisation of lysosomal Ca 2+ triggers complex Ca 2+ signals

(2012) Bethan S. Kilpatrick et al.   JOURNAL OF CELL SCIENCE

Lysosomes shape Ins(1,4,5) P 3 -evoked Ca 2+ signals by selectively sequestering Ca 2+ released from the endoplasmic reticulum

(2012) Cristina I. López-Sanjurjo et al.   JOURNAL OF CELL SCIENCE

Increased Expression of Fatty-Acid and Calcium Metabolism Genes in Failing Human Heart

(2012) Vanessa García-Rúa et al.   PLoS One

The Membrane-Bound Enzyme CD38 Exists in Two Opposing Orientations

(2012) Y. J. Zhao et al.   Science Signaling

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Regulation of autophagy by lysosomal positioning

(2011) Viktor I. Korolchuk et al.   Autophagy

NAADP influences excitation–contraction coupling by releasing calcium from lysosomes in atrial myocytes

(2011) Thomas P. Collins et al.   CELL CALCIUM

Vacuolar Ca2+ uptake

(2011) Jon K. Pittman   CELL CALCIUM

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

NAADP mediates ATP-induced Ca2+signals in astrocytes

(2011) Miquel Barceló-Torns et al.   FEBS LETTERS

Neuron Number and Size in Prefrontal Cortex of Children With Autism

(2011) Eric Courchesne et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Critical Role for CD38-mediated Ca2+Signaling in Thrombin-induced Procoagulant Activity of Mouse Platelets and Hemostasis

(2011) Mazhar Mushtaq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels

(2011) Soichiro Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Regulates Autophagy in Cultured Astrocytes

(2011) Gustavo J. S. Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells

(2011) Yaping Lin-Moshier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg

(2011) Timothy F. Walseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1 and STIM2 Are Located in the Acidic Ca2+Stores and Associates with Orai1 upon Depletion of the Acidic Stores in Human Platelets

(2011) Hanene Zbidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms

(2011) Manmeet K Mamik et al.   Journal of Neuroinflammation

Serotonin and Prefrontal Cortex Function: Neurons, Networks, and Circuits

(2011) M. Victoria Puig et al.   MOLECULAR NEUROBIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling

(2011) Hon Cheung Lee   Science China-Life Sciences

An emerging role for NAADP-mediated Ca2+signaling in the pancreatic β-cell

(2011) Abdelilah Arredouani et al.   Islets

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

(2010) Michael X. Zhu et al.   FEBS LETTERS

Generation of Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate by CD38 for Ca2+Signaling in Interleukin-8-treated Lymphokine-activated Killer Cells

(2010) So-Young Rah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acidic NAADP-sensitive Calcium Stores in the Endothelium

(2010) G. Cristina Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ecto-enzyme CD38 Is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthase That Couples Receptor Activation to Ca2+Mobilization from Lysosomes in Pancreatic Acinar Cells

(2010) François Cosker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 Proteins Mediate Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)- and Agonist-evoked Contractions of Smooth Muscle

(2010) Nezahat Tugba Durlu-Kandilci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

(2010) Samantha J. Pitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+Currents in Isolated Lysosomes

(2010) Michael Schieder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggressive behavior during social interaction in mice is controlled by the modulation of tyrosine hydroxylase expression in the prefrontal cortex

(2010) K. Cambon et al.   NEUROSCIENCE

Vesicle degradation in dendrites of magnocellular neurones of the rat supraoptic nucleus

(2010) Olivia Monteiro et al.   NEUROSCIENCE LETTERS

Two genetic variants of CD38 in subjects with autism spectrum disorder and controls

(2010) Toshio Munesue et al.   NEUROSCIENCE RESEARCH

Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels

(2010) P. K. Aley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling

(2010) Sandip Patel et al.   TRENDS IN CELL BIOLOGY

Calcium signaling via two-pore channels: local or global, that is the question

(2009) Michael X. Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Recruitment of NAADP-sensitive acidic Ca2+stores by glutamate

(2009) Vinita Pandey et al.   BIOCHEMICAL JOURNAL

Abscisic Acid Activates the Murine Microglial Cell Line N9 through the Second Messenger Cyclic ADP-ribose

(2009) Nicoletta Bodrato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analogues of the Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Antagonist Ned-19 Indicate Two Binding Sites on the NAADP Receptor

(2009) Daniel Rosen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD38/cADPR/Ca2+Pathway Promotes Cell Proliferation and Delays Nerve Growth Factor-induced Differentiation in PC12 Cells

(2009) Jianbo Yue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Ancestral Deuterostome Family of Two-pore Channels Mediates Nicotinic Acid Adenine Dinucleotide Phosphate-dependent Calcium Release from Acidic Organelles

(2009) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

CD38 regulation in activated astrocytes: Implications for neuroinflammation and HIV-1 brain infection

(2009) Wei Kou et al.   JOURNAL OF NEUROSCIENCE RESEARCH

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-riboseor Ca2+ concentrations is involved in autoregulation of oxytocin secretionin the hypothalamus and posterior pituitary in male mice

(2009) Olga Lopatina et al.   NEUROPHARMACOLOGY

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist

(2009) W. Dammermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine in the prefrontal cortex regulates rats behavioral flexibility to changing reward value

(2008) Sabrina Winter et al.   BEHAVIOURAL BRAIN RESEARCH

STIM1 regulates acidic Ca2+ store refilling by interaction with SERCA3 in human platelets

(2008) Jose J. López et al.   BIOCHEMICAL PHARMACOLOGY

Inositol trisphosphate and calcium signalling mechanisms

(2008) Michael J. Berridge   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysosomes co-localize with ryanodine receptor subtype 3 to form a trigger zone for calcium signalling by NAADP in rat pulmonary arterial smooth muscle

(2008) Nicholas P. Kinnear et al.   CELL CALCIUM

Ca2+ Signaling Occurs via Second Messenger Release from Intraorganelle Synthesis Sites

(2008) Lianne C. Davis et al.   CURRENT BIOLOGY

Regulation of Nuclear Ca2+Signaling by Translocation of the Ca2+Messenger Synthesizing Enzyme ADP-ribosyl Cyclase during Neuronal Depolarization

(2008) Stéphanie Bezin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD38/Cyclic ADP-Ribose Regulates Astrocyte Calcium Signaling: Implications for Neuroinflammation and HIV-1-Associated Dementia

(2008) Sugato Banerjee et al.   Journal of Neuroimmune Pharmacology

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

(2008) Fabio Malavasi et al.   PHYSIOLOGICAL REVIEWS

Regulation of the V-ATPase along the Endocytic Pathway Occurs through Reversible Subunit Association and Membrane Localization

(2008) Céline Lafourcade et al.   PLoS One

Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys

(2008) Emanuele Seu et al.   PSYCHOPHARMACOLOGY