TPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release

TPC: the NAADP discovery channel?: Figure 1

(2015) Anthony J. Morgan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

(2014) Y. Lin-Moshier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+

(2014) S. J. Pitt et al.   Science Signaling

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

Two-pore channels (TPCs): Current controversies

(2013) Anthony J. Morgan et al.   BIOESSAYS

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH

(2013) Yingying Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Near-infrared fluorescent proteins for multicolor in vivo imaging

(2013) Daria M Shcherbakova et al.   NATURE METHODS

Mechanism of platelet dense granule biogenesis: study of cargo transport and function of Rab32 and Rab38 in a model system

(2012) A. L. Ambrosio et al.   BLOOD

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models

(2012) R. Meng et al.   BLOOD

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing

(2012) Lianne C. Davis et al.   CURRENT BIOLOGY

NAADP regulates human platelet function

(2011) Carmen H. Coxon et al.   BIOCHEMICAL JOURNAL

Platelets at work in primary hemostasis

(2011) Katleen Broos et al.   BLOOD REVIEWS

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ecto-enzyme CD38 Is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthase That Couples Receptor Activation to Ca2+Mobilization from Lysosomes in Pancreatic Acinar Cells

(2010) François Cosker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling

(2010) Sandip Patel et al.   TRENDS IN CELL BIOLOGY

Autoprocessing of human immunodeficiency virus type 1 protease miniprecursor fusions in mammalian cells

(2010) Liangqun Huang et al.   AIDS Research and Therapy

Calcium signaling via two-pore channels: local or global, that is the question

(2009) Michael X. Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo

(2009) G. J. Graham et al.   BLOOD

Red Fluorescent Protein pH Biosensor to Detect Concentrative Nucleoside Transport

(2009) Danielle E. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Disorders of Lysosome-Related Organelle Biogenesis: Clinical and Molecular Genetics

(2008) Marjan Huizing et al.   Annual Review of Genomics and Human Genetics

The platelet release reaction: just when you thought platelet secretion was simple

(2008) Qiansheng Ren et al.   CURRENT OPINION IN HEMATOLOGY